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Strength and Endurance Training in Older Women in Relation to ACTN3 R577X and ACE I/D Polymorphisms

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  • Cristina Romero-Blanco

    (Physical Activity and Health Promotion Research Group, Universidad de Castilla-La Mancha, 45004 Toledo, Spain)

  • María Jesús Artiga-González

    (Spanish National Cancer Center (CNIO), 28029 Madrid, Spain)

  • Alba Gómez-Cabello

    (Growth, Exercise, Nutrition and Development Research Group, Universidad de Zaragoza, 50009 Zaragoza, Spain)

  • Sara Vila-Maldonado

    (Growth, Exercise, Nutrition and Development Research Group, Universidad de Castilla-La Mancha, 45071 Toledo, Spain
    CIBERFES Biomedical Research Networking Center on Frailty and Health Aging, 28029 Madrid, Spain)

  • José Antonio Casajús

    (Growth, Exercise, Nutrition and Development Research Group, Universidad de Zaragoza, 50009 Zaragoza, Spain)

  • Ignacio Ara

    (Growth, Exercise, Nutrition and Development Research Group, Universidad de Castilla-La Mancha, 45071 Toledo, Spain
    CIBERFES Biomedical Research Networking Center on Frailty and Health Aging, 28029 Madrid, Spain)

  • Susana Aznar

    (Physical Activity and Health Promotion Research Group, Universidad de Castilla-La Mancha, 45004 Toledo, Spain
    CIBERFES Biomedical Research Networking Center on Frailty and Health Aging, 28029 Madrid, Spain)

Abstract

The purpose of this study is to analyze the effect of two genetic polymorphisms, ACTN3 R577X , and ACE I/D , on physical condition in a sample of active older women after a two-year training period. The sample was composed of 300 healthy women over the age of 60 who underwent a two-year training program. Adapted tests from the Senior Fitness Test were used. The genotyping of the polymorphisms was obtained from the participants’ DNA via buccal swabs. The analysis of the ACE polymorphism did not reveal differences between genotypes. The analysis of the R577X polymorphism showed a favorable effect for the ACTN3 XX genotype in tests for leg strength ( p : 0.001) after training, compared to the other genotypes, and also in the analysis of the combined effect of the polymorphism ( ACE II + ACTN3 RX/XX ). The intragroup effect revealed an improvement in arm strength for carriers of the X allele after 24 months of training ( p < 0.05). The endurance values significantly worsened in all study groups. Conclusions: The R577X polymorphism of ACTN3 may have an important role in capacities related to muscle strength, providing a beneficial effect for carriers of the X allele.

Suggested Citation

  • Cristina Romero-Blanco & María Jesús Artiga-González & Alba Gómez-Cabello & Sara Vila-Maldonado & José Antonio Casajús & Ignacio Ara & Susana Aznar, 2020. "Strength and Endurance Training in Older Women in Relation to ACTN3 R577X and ACE I/D Polymorphisms," IJERPH, MDPI, vol. 17(4), pages 1-10, February.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:4:p:1236-:d:320705
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    References listed on IDEAS

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    1. Fang Ma & Yu Yang & Xiangwei Li & Feng Zhou & Cong Gao & Mufei Li & Lei Gao, 2013. "The Association of Sport Performance with ACE and ACTN3 Genetic Polymorphisms: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-9, January.
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    Keywords

    ACE ; ACTN3 ; physical fitness; genotype; women; elderly;
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