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Prevalence of Polymorphism and Post-Training Expression of ACTN3 (R/X) and ACE (I/D) Genes in CrossFit Athletes

Author

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  • Omar Peña-Vázquez

    (Faculty of Physical Culture Sciences, Autonomous University of Chihuahua, Campus II, Circuito Universitario S/N, Chihuahua 31125, Mexico)

  • Liliana Aracely Enriquez-del Castillo

    (Faculty of Physical Culture Sciences, Autonomous University of Chihuahua, Campus II, Circuito Universitario S/N, Chihuahua 31125, Mexico)

  • Susana Aideé González-Chávez

    (PABIOM Laboratory, Faculty of Medicine and Biomedical Sciences, Autonomous University of Chihuahua, Campus II, Circuito Universitario S/N, Chihuahua 31109, Mexico)

  • Jaime Güereca-Arvizuo

    (Department of Health Sciences, Multidisciplinary Division of Ciudad Universitaria, Autonomous University of Cd. Juárez, Ciudad Juárez 32310, Mexico)

  • Ramon Candia Lujan

    (Faculty of Physical Culture Sciences, Autonomous University of Chihuahua, Campus II, Circuito Universitario S/N, Chihuahua 31125, Mexico)

  • Claudia Esther Carrasco Legleu

    (Faculty of Physical Culture Sciences, Autonomous University of Chihuahua, Campus II, Circuito Universitario S/N, Chihuahua 31125, Mexico)

  • Natanael Cervantes Hernández

    (Faculty of Physical Culture Sciences, Autonomous University of Chihuahua, Campus II, Circuito Universitario S/N, Chihuahua 31125, Mexico)

  • César Pacheco-Tena

    (PABIOM Laboratory, Faculty of Medicine and Biomedical Sciences, Autonomous University of Chihuahua, Campus II, Circuito Universitario S/N, Chihuahua 31109, Mexico)

Abstract

Background: CrossFit is known as a functional fitness training high-intensity exercise to improve physical performance. The most studied polymorphisms are the ACTN3 R577X gene, known for speed, power, and strength, and ACE I/D, related to endurance and strength. The present investigation analyzed the effects of training on ACTN3 and ACE gene expression in CrossFit athletes for 12 weeks. Methods: the studies included 18 athletes from the Rx category, where ACTN3 (RR, RX, XX) and ACE (II, ID, DD) characterization of genotypes and tests of maximum strength (NSCA), power (T-Force), and aerobic endurance (Course Navette) were performed. The technique used was the reverse transcription-quantitative PCR real-time polymerase chain reaction (RT-qPCR) for the relative expression analysis. Results: the relative quantification (RQ) values for the ACTN3 gene increased their levels 2.3 times ( p = 0.035), and for ACE, they increased 3.0 times ( p = 0.049). Conclusions: there is an overexpression of the ACTN3 and ACE genes due to the effect of training for 12 weeks. Additionally, the correlation of the expression of the ACTN3 ( p = 0.040) and ACE ( p = 0.030) genes with power was verified.

Suggested Citation

  • Omar Peña-Vázquez & Liliana Aracely Enriquez-del Castillo & Susana Aideé González-Chávez & Jaime Güereca-Arvizuo & Ramon Candia Lujan & Claudia Esther Carrasco Legleu & Natanael Cervantes Hernández & , 2023. "Prevalence of Polymorphism and Post-Training Expression of ACTN3 (R/X) and ACE (I/D) Genes in CrossFit Athletes," IJERPH, MDPI, vol. 20(5), pages 1-13, March.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:5:p:4404-:d:1084605
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    References listed on IDEAS

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    1. Fang Ma & Yu Yang & Xiangwei Li & Feng Zhou & Cong Gao & Mufei Li & Lei Gao, 2013. "The Association of Sport Performance with ACE and ACTN3 Genetic Polymorphisms: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-9, January.
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