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A Meta-Analysis of Apolipoprotein E Gene ε2/ε3/ε4 Polymorphism for Gallbladder Stone Disease

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Listed:
  • Pei Xue
  • Wen-Quan Niu
  • Zhao-Yan Jiang
  • Min-Hua Zheng
  • Jian Fei

Abstract

Background: Numerous studies have investigated the relationship between apolipoprotein (Apo) E gene polymorphisms and gallbladder stone disease (GSD) across ethnic populations; however, the results are often inconsistent. This meta-analysis aims to comprehensively evaluate the influence of a common ε2/ε3/ε4 polymorphism in Apo E gene on the risk of gallbladder stone disease. Method: Data were analyzed using the RevMan software (V5.1) and a random-effects model was applied irrespective of between-study heterogeneity. Publication bias was weighed using the fail-safe number. Results: There were 17 study populations totaling 1773 cases and 2751 controls for ε2/ε3/ε4 polymorphism of Apo E gene. Overall comparison of alleles ε2 with ε3 in all study populations yielded a 16% decreased risk for GSD (95% confidence interval [95% CI]: 0.68–1.05; P = 0.31; I2 = 13%), and comparison of alleles ε4 with ε3 yielded a 25% increased risk (95% confidence interval [95% CI]: 0.97–1.61; P = 0.0003; I2 = 63%). Subgroup analysis by study design indicated that the magnitude of association in hospital-based studies was largely significantly strengthened for ε4 allelic model (odds ratio [OR] = 1.46; 95% CI: 1.05–2.02; p = 0.0007; I2 = 65%). Subgroup analysis by age of controls indicated a remarkably significant elevation in the magnitude of association in age >50 subgroups in ε4 allelic model (OR = 1.50; 95% CI: 1.03–2.19; p = 0.0009; I2 = 72%). Moreover, subgroup analysis by cases gender indicated a reduction in the magnitude of association in male

Suggested Citation

  • Pei Xue & Wen-Quan Niu & Zhao-Yan Jiang & Min-Hua Zheng & Jian Fei, 2012. "A Meta-Analysis of Apolipoprotein E Gene ε2/ε3/ε4 Polymorphism for Gallbladder Stone Disease," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-6, September.
    • Handle: RePEc:plo:pone00:0045849
    DOI: 10.1371/journal.pone.0045849
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    References listed on IDEAS

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    1. Wenquan Niu & Yue Qi, 2011. "An Updated Meta-Analysis of Endothelial Nitric Oxide Synthase Gene: Three Well-Characterized Polymorphisms with Hypertension," PLOS ONE, Public Library of Science, vol. 6(9), pages 1-10, September.
    2. Wenquan Niu & Yue Qi, 2011. "Association of α-Adducin and G-Protein β3 Genetic Polymorphisms with Hypertension: A Meta-Analysis of Chinese Populations," PLOS ONE, Public Library of Science, vol. 6(2), pages 1-7, February.
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    1. Qiang Cai & Jian Wu & Qu Cai & Er-Zhen Chen & Zhao-Yan Jiang, 2015. "Association between Glu504Lys Polymorphism of ALDH2 Gene and Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-16, February.
    2. Yi Gong & Leida Zhang & Ping Bie & Huaizhi Wang, 2013. "Roles of ApoB-100 Gene Polymorphisms and the Risks of Gallstones and Gallbladder Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-9, April.
    3. Zhao-Yan Jiang & Qu Cai & Er-Zhen Chen, 2014. "Association of Three Common Single Nucleotide Polymorphisms of ATP Binding Cassette G8 Gene with Gallstone Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-11, January.
    4. Daniel Mønsted Shabanzadeh & Lars Tue Sørensen & Torben Jørgensen, 2017. "Gallstone disease and mortality: a cohort study," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 62(3), pages 353-360, April.

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