IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0045849.html
   My bibliography  Save this article

A Meta-Analysis of Apolipoprotein E Gene ε2/ε3/ε4 Polymorphism for Gallbladder Stone Disease

Author

Listed:
  • Pei Xue
  • Wen-Quan Niu
  • Zhao-Yan Jiang
  • Min-Hua Zheng
  • Jian Fei

Abstract

Background: Numerous studies have investigated the relationship between apolipoprotein (Apo) E gene polymorphisms and gallbladder stone disease (GSD) across ethnic populations; however, the results are often inconsistent. This meta-analysis aims to comprehensively evaluate the influence of a common ε2/ε3/ε4 polymorphism in Apo E gene on the risk of gallbladder stone disease. Method: Data were analyzed using the RevMan software (V5.1) and a random-effects model was applied irrespective of between-study heterogeneity. Publication bias was weighed using the fail-safe number. Results: There were 17 study populations totaling 1773 cases and 2751 controls for ε2/ε3/ε4 polymorphism of Apo E gene. Overall comparison of alleles ε2 with ε3 in all study populations yielded a 16% decreased risk for GSD (95% confidence interval [95% CI]: 0.68–1.05; P = 0.31; I2 = 13%), and comparison of alleles ε4 with ε3 yielded a 25% increased risk (95% confidence interval [95% CI]: 0.97–1.61; P = 0.0003; I2 = 63%). Subgroup analysis by study design indicated that the magnitude of association in hospital-based studies was largely significantly strengthened for ε4 allelic model (odds ratio [OR] = 1.46; 95% CI: 1.05–2.02; p = 0.0007; I2 = 65%). Subgroup analysis by age of controls indicated a remarkably significant elevation in the magnitude of association in age >50 subgroups in ε4 allelic model (OR = 1.50; 95% CI: 1.03–2.19; p = 0.0009; I2 = 72%). Moreover, subgroup analysis by cases gender indicated a reduction in the magnitude of association in male

Suggested Citation

  • Pei Xue & Wen-Quan Niu & Zhao-Yan Jiang & Min-Hua Zheng & Jian Fei, 2012. "A Meta-Analysis of Apolipoprotein E Gene ε2/ε3/ε4 Polymorphism for Gallbladder Stone Disease," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-6, September.
    • Handle: RePEc:plo:pone00:0045849
    DOI: 10.1371/journal.pone.0045849
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045849
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0045849&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0045849?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Wenquan Niu & Yue Qi, 2011. "An Updated Meta-Analysis of Endothelial Nitric Oxide Synthase Gene: Three Well-Characterized Polymorphisms with Hypertension," PLOS ONE, Public Library of Science, vol. 6(9), pages 1-10, September.
    2. Wenquan Niu & Yue Qi, 2011. "Association of α-Adducin and G-Protein β3 Genetic Polymorphisms with Hypertension: A Meta-Analysis of Chinese Populations," PLOS ONE, Public Library of Science, vol. 6(2), pages 1-7, February.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Zhao-Yan Jiang & Qu Cai & Er-Zhen Chen, 2014. "Association of Three Common Single Nucleotide Polymorphisms of ATP Binding Cassette G8 Gene with Gallstone Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-11, January.
    2. Daniel Mønsted Shabanzadeh & Lars Tue Sørensen & Torben Jørgensen, 2017. "Gallstone disease and mortality: a cohort study," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 62(3), pages 353-360, April.
    3. Qiang Cai & Jian Wu & Qu Cai & Er-Zhen Chen & Zhao-Yan Jiang, 2015. "Association between Glu504Lys Polymorphism of ALDH2 Gene and Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-16, February.
    4. Yi Gong & Leida Zhang & Ping Bie & Huaizhi Wang, 2013. "Roles of ApoB-100 Gene Polymorphisms and the Risks of Gallstones and Gallbladder Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-9, April.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Meiyun Wang & Xiubo Jiang & Wenlong Wu & Dongfeng Zhang, 2013. "Endothelial NO Synthase Gene Polymorphisms and Risk of Ischemic Stroke in Asian Population: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-9, March.
    2. Yan-yan Li, 2012. "α-Adducin Gly460Trp Gene Mutation and Essential Hypertension in a Chinese Population: A Meta-Analysis including 10960 Subjects," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-12, January.
    3. Xiaobo Li & Yuqiong Li & Bei Song & Shujie Guo & Shaoli Chu & Nan Jia & Wenquan Niu, 2012. "Hematopoietically-Expressed Homeobox Gene Three Widely-Evaluated Polymorphisms and Risk for Diabetes: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-10, November.
    4. Mei-Ling Chen & Tzu-Pi Huang & Tai-Wei Chen & Hsin-Hua Chan & Bing-Fang Hwang, 2018. "Interactions of Genes and Sodium Intake on the Development of Hypertension: A Cohort-Based Case-Control Study," IJERPH, MDPI, vol. 15(6), pages 1-10, May.
    5. Lu Guo & Li-Li Zhang & Bo Zheng & Yun Liu & Xiao-Jie Cao & Yan Pi & Bing-Hu Li & Jing-Cheng Li, 2013. "The C825T Polymorphism of the G-Protein β3 Subunit Gene and Its Association with Hypertension and Stroke: An Updated Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-13, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0045849. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.