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Association of Three Common Single Nucleotide Polymorphisms of ATP Binding Cassette G8 Gene with Gallstone Disease: A Meta-Analysis

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  • Zhao-Yan Jiang
  • Qu Cai
  • Er-Zhen Chen

Abstract

Background: In this study, we evaluated the association between these polymorphisms and gallstone disease using meta-analysis and compared the hepatic ABCG5/G8 mRNA expression and biliary lipids composition in patients with different genotypes of T400K and Y54C. Methods: Data were analyzed using the Stata/SE 11.0 software and a random- effects model was applied irrespective of between-study heterogeneity. Hepatic mRNA expression of ABCG5/G8 genes in 182 patients with gallstone disease and 35 gallstone-free patients who underwent cholecystectomy were determined using real-time PCR. Genotypes of Y54C and T400K in the ABCG8 gene were determined by allelic discrimination using either genomic DNA or hepatic cDNA as template by Taqman assays. Biliary compostion in gallbladder bile was assayed in these patients as well. Results: Ten papers including 13 cohorts were included for the final analysis. In the genotype model, the overall association between genotype with gallstone was significant for D19H (OR = 2.43, 95%CI: 2.23–2.64, P

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  • Zhao-Yan Jiang & Qu Cai & Er-Zhen Chen, 2014. "Association of Three Common Single Nucleotide Polymorphisms of ATP Binding Cassette G8 Gene with Gallstone Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-11, January.
    • Handle: RePEc:plo:pone00:0087200
    DOI: 10.1371/journal.pone.0087200
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    References listed on IDEAS

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    1. Pei Xue & Wen-Quan Niu & Zhao-Yan Jiang & Min-Hua Zheng & Jian Fei, 2012. "A Meta-Analysis of Apolipoprotein E Gene ε2/ε3/ε4 Polymorphism for Gallbladder Stone Disease," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-6, September.
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    1. Daniel Mønsted Shabanzadeh & Lars Tue Sørensen & Torben Jørgensen, 2017. "Gallstone disease and mortality: a cohort study," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 62(3), pages 353-360, April.

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