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Association of α-Adducin and G-Protein β3 Genetic Polymorphisms with Hypertension: A Meta-Analysis of Chinese Populations

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  • Wenquan Niu
  • Yue Qi

Abstract

Background: Mounting evidence has suggested that α-adducin and G-protein β3 (GNB3) genes are logical candidates for salt-sensitive hypertension. Some, but not all, studies have reported that α-adducin G460T and GNB3 C825T polymorphisms may influence the risk of the disease. To comprehensively address this issue, we performed a meta-analysis to evaluate the influence of these two polymorphisms on hypertension and potential biases in Chinese. Methods: Data were analyzed using Stata (v11.0) and random-effects model was applied irrespective of between-studies heterogeneity, which was evaluated via subgroup and meta-regression analyses. Study quality was assessed in duplicate. Publication bias was weighed using Egger's test and funnel plot. Results: 36 study populations totaling 9042 hypertensive patients and 8399 controls were finally identified. Overall, in allelic/genotypic/dominant/recessive models, no significant association was identified for both G460T and C825T polymorphisms (P>0.05) and there was possible heterogeneity (I2>25%). Subgroup analyses by study design indicated that the magnitude of association in population-based studies was marginally significantly strengthened for α-adducin G460T allelic model (OR = 1.12; 95% CI: 1:00–1.25; P = 0.043). Moreover, subgroup analyses by geographic distribution indicated comparison of 825T with 825C yielded a marginally significant increased risk in southern Chinese only (OR = 1.48; 95% CI: 1.01–2.16; P = 0.045). Further meta-regression analyses showed that geographic regions were a significant source of between-study heterogeneity for both polymorphisms. There was a possibility of publication bias for G460T, but not for C825T. Conclusions: Our overall results suggest null association of α-adducin G460T and GNB3 C825T polymorphisms with hypertension in Chinese but indicate local marginal significance of C825T, as a putative salt-sensitive switch, in southern Chinese.

Suggested Citation

  • Wenquan Niu & Yue Qi, 2011. "Association of α-Adducin and G-Protein β3 Genetic Polymorphisms with Hypertension: A Meta-Analysis of Chinese Populations," PLOS ONE, Public Library of Science, vol. 6(2), pages 1-7, February.
    • Handle: RePEc:plo:pone00:0017052
    DOI: 10.1371/journal.pone.0017052
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    Cited by:

    1. Lu Guo & Li-Li Zhang & Bo Zheng & Yun Liu & Xiao-Jie Cao & Yan Pi & Bing-Hu Li & Jing-Cheng Li, 2013. "The C825T Polymorphism of the G-Protein β3 Subunit Gene and Its Association with Hypertension and Stroke: An Updated Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-13, June.
    2. Pei Xue & Wen-Quan Niu & Zhao-Yan Jiang & Min-Hua Zheng & Jian Fei, 2012. "A Meta-Analysis of Apolipoprotein E Gene ε2/ε3/ε4 Polymorphism for Gallbladder Stone Disease," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-6, September.
    3. Mei-Ling Chen & Tzu-Pi Huang & Tai-Wei Chen & Hsin-Hua Chan & Bing-Fang Hwang, 2018. "Interactions of Genes and Sodium Intake on the Development of Hypertension: A Cohort-Based Case-Control Study," IJERPH, MDPI, vol. 15(6), pages 1-10, May.
    4. Xiaobo Li & Yuqiong Li & Bei Song & Shujie Guo & Shaoli Chu & Nan Jia & Wenquan Niu, 2012. "Hematopoietically-Expressed Homeobox Gene Three Widely-Evaluated Polymorphisms and Risk for Diabetes: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-10, November.
    5. Yan-yan Li, 2012. "α-Adducin Gly460Trp Gene Mutation and Essential Hypertension in a Chinese Population: A Meta-Analysis including 10960 Subjects," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-12, January.

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