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Gallstone disease and mortality: a cohort study

Author

Listed:
  • Daniel Mønsted Shabanzadeh

    (Bispebjerg University Hospital
    Centre for Health)

  • Lars Tue Sørensen

    (Bispebjerg University Hospital
    University of Copenhagen)

  • Torben Jørgensen

    (Centre for Health
    University of Copenhagen
    Aalborg University)

Abstract

Objectives The objective of this cohort study was to determine whether subjects with gallstone disease identified by screening of a general population had increased overall mortality when compared to gallstone-free participants and to explore causes of death. Methods The study population (N = 5928) was examined 1982–1992 and included an abdominal ultrasound examination to assess gallstone status, a physical examination, blood samples, and a questionnaire about medical history. Participants were followed up through national registers until 2015. Multiple adjusted Cox regression models were built. Results Gallstone disease was present in 10%. Mortality was 46% during median 24.7 years of follow-up with 1% lost. Overall mortality and death from cardiovascular diseases were significantly associated to gallstone disease. Death from unknown causes was significantly associated to gallstone disease and death from cancer and gastrointestinal disease was not associated. No differences in mortality for ultrasound-proven gallstones or cholecystectomy were identified. Conclusions Gallstone disease is associated with increased overall mortality and to death from cardiovascular disease. Gallstones may be considered a possible cardiometabolic risk factor. Other unknown factors also seem to play a role.

Suggested Citation

  • Daniel Mønsted Shabanzadeh & Lars Tue Sørensen & Torben Jørgensen, 2017. "Gallstone disease and mortality: a cohort study," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 62(3), pages 353-360, April.
    • Handle: RePEc:spr:ijphth:v:62:y:2017:i:3:d:10.1007_s00038-016-0916-7
    DOI: 10.1007/s00038-016-0916-7
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    References listed on IDEAS

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    1. Zhao-Yan Jiang & Qu Cai & Er-Zhen Chen, 2014. "Association of Three Common Single Nucleotide Polymorphisms of ATP Binding Cassette G8 Gene with Gallstone Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-11, January.
    2. Pei Xue & Wen-Quan Niu & Zhao-Yan Jiang & Min-Hua Zheng & Jian Fei, 2012. "A Meta-Analysis of Apolipoprotein E Gene ε2/ε3/ε4 Polymorphism for Gallbladder Stone Disease," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-6, September.
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    1. Zhao-Yan Jiang & Qu Cai & Er-Zhen Chen, 2014. "Association of Three Common Single Nucleotide Polymorphisms of ATP Binding Cassette G8 Gene with Gallstone Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-11, January.
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