IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0117173.html
   My bibliography  Save this article

Association between Glu504Lys Polymorphism of ALDH2 Gene and Cancer Risk: A Meta-Analysis

Author

Listed:
  • Qiang Cai
  • Jian Wu
  • Qu Cai
  • Er-Zhen Chen
  • Zhao-Yan Jiang

Abstract

Background: The association of the aldehyde dehydrogenases-2 (ALDH2) Glu504Lys polymorphism (also named Glu487Lys, or rs671) and cancers has been investigated. This meta-analysis aims to comprehensively assess the influence of this polymorphism on the overall cancer risk. Methods: Eligible publications were retrieved according to inclusion/exclusion criteria and the data were analyzed using the Review Manager software (V5.2). Results: A meta-analysis based on 51 case-control studies consisting of 16774 cases and 32060 controls was performed to evaluate the association between the ALDH2 Glu504Lys polymorphism and cancer risk. The comparison of genotypes Lys+ (Lys/Lys and Lys/Glu) with Glu/Glu yielded a significant 20% increased cancer risk (OR = 1.20, 95%CI: 1.03–1.39, P = 0.02, I2 = 92%). Subgroup analysis by cancer type indicated a significantly increased UADT cancer risk (OR = 1.39, 95%CI: 1.11–1.73, P = 0.004, I2 = 94%) in individuals with the Lys+ genotypes. Subgroup analysis by country indicated that individuals from Japan with the Lys+ genotypes had a significant 38% increased cancer risk (OR = 1.38, 95%CI: 1.12–1.71, P = 0.003, I2 = 93%). Conclusions: Our results indicated that the ALDH2 Glu504Lys polymorphism is a susceptible loci associated with overall cancers, especially esophageal cancer and among Japanese population.

Suggested Citation

  • Qiang Cai & Jian Wu & Qu Cai & Er-Zhen Chen & Zhao-Yan Jiang, 2015. "Association between Glu504Lys Polymorphism of ALDH2 Gene and Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-16, February.
    • Handle: RePEc:plo:pone00:0117173
    DOI: 10.1371/journal.pone.0117173
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117173
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117173&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0117173?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Hua Zhao & Kui-Jie Liu & Zhen-Dong Lei & San-Lin Lei & Yong-Quan Tian, 2014. "Meta-Analysis of the Aldehyde Dehydrogenases-2 (ALDH2) Glu487Lys Polymorphism and Colorectal Cancer Risk," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-8, February.
    2. Pei Xue & Wen-Quan Niu & Zhao-Yan Jiang & Min-Hua Zheng & Jian Fei, 2012. "A Meta-Analysis of Apolipoprotein E Gene ε2/ε3/ε4 Polymorphism for Gallbladder Stone Disease," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-6, September.
    3. He-Ling Wang & Ping-Yi Zhou & Peng Liu & Yu Zhang, 2014. "ALDH2 and ADH1 Genetic Polymorphisms May Contribute to the Risk of Gastric Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-11, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Sarah Soyeon Oh & Yeong Jun Ju & San Lee & Eun-Cheol Park, 2019. "Primary Reason for Drinking Among Current, Former, and Never Flushing College Students," IJERPH, MDPI, vol. 16(2), pages 1-13, January.
    2. Zhao-Yan Jiang & Qu Cai & Er-Zhen Chen, 2014. "Association of Three Common Single Nucleotide Polymorphisms of ATP Binding Cassette G8 Gene with Gallstone Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-11, January.
    3. Daniel Mønsted Shabanzadeh & Lars Tue Sørensen & Torben Jørgensen, 2017. "Gallstone disease and mortality: a cohort study," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 62(3), pages 353-360, April.
    4. Yi Gong & Leida Zhang & Ping Bie & Huaizhi Wang, 2013. "Roles of ApoB-100 Gene Polymorphisms and the Risks of Gallstones and Gallbladder Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-9, April.
    5. Yunzhong Yang & Tianhua Niu, 2018. "A meta-analysis of associations of LEPR Q223R and K109R polymorphisms with Type 2 diabetes risk," PLOS ONE, Public Library of Science, vol. 13(1), pages 1-25, January.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0117173. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.