IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v15y2018i6p1110-d149625.html
   My bibliography  Save this article

Interactions of Genes and Sodium Intake on the Development of Hypertension: A Cohort-Based Case-Control Study

Author

Listed:
  • Mei-Ling Chen

    (College of Human Science and Social Innovation, HungKuang University, No. 1018, Sec. 6, Taiwan Boulevard, Shalu District, Taichung 43302, Taiwan)

  • Tzu-Pi Huang

    (Department of Plant Pathology, National Chung Hsing University, Taichung 402 Taiwan)

  • Tai-Wei Chen

    (Department of Occupational Safety and Heath, College of Public Health, China Medical University, No 91 Hsueh-Shih Rd, Taichung 40402, Taiwan)

  • Hsin-Hua Chan

    (Department of Occupational Safety and Heath, College of Public Health, China Medical University, No 91 Hsueh-Shih Rd, Taichung 40402, Taiwan)

  • Bing-Fang Hwang

    (Department of Occupational Safety and Heath, College of Public Health, China Medical University, No 91 Hsueh-Shih Rd, Taichung 40402, Taiwan)

Abstract

There have been few studies investigating interactions of G-protein beta3 subunit ( GNB3 ) C825T (rs5443) and dietary sodium intake on the risk of hypertension, i.e., BP salt sensitivity. The study aims to evaluate joint effects of GNB3 polymorphisms and sodium consumption on the development of hypertension. A cohort-based case-control study was conducted in 2014. There are 233 participants with newly diagnosed hypertension in the case group and 699 participants in the gender-matched control group. The primary outcome is the development of hypertension over a 10-year period. The determinants of hypertension were three genotypes of SNP in GNB3 (TT; CT; and CC) and two dietary salt categories on the basis of the level of sodium consumption representing high (>4800 mg/day) and low-sodium (<2400 mg/day) diets. The development of hypertension increased with participants carrying TT genotype and high-sodium diets comparing with those carrying TC or CC genotype with low-sodium diets (adjusted OR 3.23, 95% CI 1.52–6.83) (Rothman synergy index = 3.79). The study suggests that GNB3 C825T polymorphism may influence the response of the renin-angiotensin system to high-sodium diet. It implies that GNB3 can be served as an easy, inexpensive, and early genetic marker of salt sensitivity to blood pressure. Salt-sensitive individuals should pay more attention to salt intake to reduce cardiovascular morbidity or mortality.

Suggested Citation

  • Mei-Ling Chen & Tzu-Pi Huang & Tai-Wei Chen & Hsin-Hua Chan & Bing-Fang Hwang, 2018. "Interactions of Genes and Sodium Intake on the Development of Hypertension: A Cohort-Based Case-Control Study," IJERPH, MDPI, vol. 15(6), pages 1-10, May.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:6:p:1110-:d:149625
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/15/6/1110/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/15/6/1110/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Wenquan Niu & Yue Qi, 2011. "Association of α-Adducin and G-Protein β3 Genetic Polymorphisms with Hypertension: A Meta-Analysis of Chinese Populations," PLOS ONE, Public Library of Science, vol. 6(2), pages 1-7, February.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Pei Xue & Wen-Quan Niu & Zhao-Yan Jiang & Min-Hua Zheng & Jian Fei, 2012. "A Meta-Analysis of Apolipoprotein E Gene ε2/ε3/ε4 Polymorphism for Gallbladder Stone Disease," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-6, September.
    2. Yan-yan Li, 2012. "α-Adducin Gly460Trp Gene Mutation and Essential Hypertension in a Chinese Population: A Meta-Analysis including 10960 Subjects," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-12, January.
    3. Xiaobo Li & Yuqiong Li & Bei Song & Shujie Guo & Shaoli Chu & Nan Jia & Wenquan Niu, 2012. "Hematopoietically-Expressed Homeobox Gene Three Widely-Evaluated Polymorphisms and Risk for Diabetes: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-10, November.
    4. Lu Guo & Li-Li Zhang & Bo Zheng & Yun Liu & Xiao-Jie Cao & Yan Pi & Bing-Hu Li & Jing-Cheng Li, 2013. "The C825T Polymorphism of the G-Protein β3 Subunit Gene and Its Association with Hypertension and Stroke: An Updated Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-13, June.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:15:y:2018:i:6:p:1110-:d:149625. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.