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Roles of ApoB-100 Gene Polymorphisms and the Risks of Gallstones and Gallbladder Cancer: A Meta-Analysis

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  • Yi Gong
  • Leida Zhang
  • Ping Bie
  • Huaizhi Wang

Abstract

Background: Gallstones (GS) is the major manifestation of gallbladder disease, and is the most common risk factor for gallbladder cancer (GBC). Previous studies investigating the association between ApoB-100 gene polymorphisms and the risks of GS and GBC have yielded conflicting results. Therefore, we performed a meta-analysis to clarify the effects of ApoB-100 gene polymorphisms on the risks of GS and GBC. Methods: A computerized literature search was conducted to identify the relevant studies from PubMed and Embase. Fixed or random effects model was selected based on heterogeneity test. Publication bias was estimated using Begg’s funnel plots and Egger’s regression test. Results: A total of 10, 3, and 3 studies were included in the analyses of the association between ApoB-100 XbaI, EcoRI, or insertion/deletion (ID) polymorphisms and the GS risks, respectively, while 3 studies were included in the analysis for the association between XbaI polymorphism and GBC risk. The combined results showed a significant association in Chinese (X+ vs. X−, OR = 2.37, 95%CI 1.52–3.70; X+X+/X+X- vs. X+X+, OR = 2.47, 95%CI 1.55–3.92), but not in Indians or Caucasians. Null association was observed between EcoRI or ID polymorphisms and GS risks. With regard to the association between XbaI polymorphism and GBC risk, a significant association was detected when GBC patients were compared with healthy persons and when GBC patients were compared with GS patients. A significant association was still detected when GBC patients (with GS) were compared with the GS patients (X+X+ vs. X-X−, OR = 0.33, 95%CI 0.12–0.90). Conclusion: The results of this meta-analysis suggest that the ApoB-100 X+ allele might be associated with increased risk of GS in Chinese but not in other populations, while the ApoB-100 X+X+ genotype might be associated with reduced risk of GBC. Further studies with larger sample sizes are needed to confirm these results.

Suggested Citation

  • Yi Gong & Leida Zhang & Ping Bie & Huaizhi Wang, 2013. "Roles of ApoB-100 Gene Polymorphisms and the Risks of Gallstones and Gallbladder Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-9, April.
    • Handle: RePEc:plo:pone00:0061456
    DOI: 10.1371/journal.pone.0061456
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    1. Roger M. Harbord & Ross J. Harris & Jonathan A. C. Sterne, 2009. "Updated tests for small-study effects in meta-analyses," Stata Journal, StataCorp LP, vol. 9(2), pages 197-210, June.
    2. Jin-Wei Cheng & Shi-Wei Cheng & Xiao-Ye Ma & Ji-Ping Cai & You Li & Guo-Cai Lu & Rui-Li Wei, 2012. "Myocilin Polymorphisms and Primary Open-Angle Glaucoma: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-6, September.
    3. Pei Xue & Wen-Quan Niu & Zhao-Yan Jiang & Min-Hua Zheng & Jian Fei, 2012. "A Meta-Analysis of Apolipoprotein E Gene ε2/ε3/ε4 Polymorphism for Gallbladder Stone Disease," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-6, September.
    4. Tao Zeng & Fang-Fang Guo & Cui-Li Zhang & Fu-Yong Song & Xiu-Lan Zhao & Ke-Qin Xie, 2013. "Roles of Cytochrome P4502E1 Gene Polymorphisms and the Risks of Alcoholic Liver Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-8, January.
    5. Aurelio Tobias, 1999. "Assessing the influence of a single study in the meta-anyalysis estimate," Stata Technical Bulletin, StataCorp LP, vol. 8(47).
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