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A Multi-Label Predictor for Identifying the Subcellular Locations of Singleplex and Multiplex Eukaryotic Proteins

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  • Xiao Wang
  • Guo-Zheng Li

Abstract

Subcellular locations of proteins are important functional attributes. An effective and efficient subcellular localization predictor is necessary for rapidly and reliably annotating subcellular locations of proteins. Most of existing subcellular localization methods are only used to deal with single-location proteins. Actually, proteins may simultaneously exist at, or move between, two or more different subcellular locations. To better reflect characteristics of multiplex proteins, it is highly desired to develop new methods for dealing with them. In this paper, a new predictor, called Euk-ECC-mPLoc, by introducing a powerful multi-label learning approach which exploits correlations between subcellular locations and hybridizing gene ontology with dipeptide composition information, has been developed that can be used to deal with systems containing both singleplex and multiplex eukaryotic proteins. It can be utilized to identify eukaryotic proteins among the following 22 locations: (1) acrosome, (2) cell membrane, (3) cell wall, (4) centrosome, (5) chloroplast, (6) cyanelle, (7) cytoplasm, (8) cytoskeleton, (9) endoplasmic reticulum, (10) endosome, (11) extracellular, (12) Golgi apparatus, (13) hydrogenosome, (14) lysosome, (15) melanosome, (16) microsome, (17) mitochondrion, (18) nucleus, (19) peroxisome, (20) spindle pole body, (21) synapse, and (22) vacuole. Experimental results on a stringent benchmark dataset of eukaryotic proteins by jackknife cross validation test show that the average success rate and overall success rate obtained by Euk-ECC-mPLoc were 69.70% and 81.54%, respectively, indicating that our approach is quite promising. Particularly, the success rates achieved by Euk-ECC-mPLoc for small subsets were remarkably improved, indicating that it holds a high potential for simulating the development of the area. As a user-friendly web-server, Euk-ECC-mPLoc is freely accessible to the public at the website http://levis.tongji.edu.cn:8080/bioinfo/Euk-ECC-mPLoc/. We believe that Euk-ECC-mPLoc may become a useful high-throughput tool, or at least play a complementary role to the existing predictors in identifying subcellular locations of eukaryotic proteins.

Suggested Citation

  • Xiao Wang & Guo-Zheng Li, 2012. "A Multi-Label Predictor for Identifying the Subcellular Locations of Singleplex and Multiplex Eukaryotic Proteins," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-9, May.
    • Handle: RePEc:plo:pone00:0036317
    DOI: 10.1371/journal.pone.0036317
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    References listed on IDEAS

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    1. Wei-Zhong Lin & Jian-An Fang & Xuan Xiao & Kuo-Chen Chou, 2011. "iDNA-Prot: Identification of DNA Binding Proteins Using Random Forest with Grey Model," PLOS ONE, Public Library of Science, vol. 6(9), pages 1-7, September.
    2. Pu Wang & Xuan Xiao & Kuo-Chen Chou, 2011. "NR-2L: A Two-Level Predictor for Identifying Nuclear Receptor Subfamilies Based on Sequence-Derived Features," PLOS ONE, Public Library of Science, vol. 6(8), pages 1-9, August.
    3. Xuan Xiao & Zhi-Cheng Wu & Kuo-Chen Chou, 2011. "A Multi-Label Classifier for Predicting the Subcellular Localization of Gram-Negative Bacterial Proteins with Both Single and Multiple Sites," PLOS ONE, Public Library of Science, vol. 6(6), pages 1-10, June.
    4. Kuo-Chen Chou & Hong-Bin Shen, 2010. "Plant-mPLoc: A Top-Down Strategy to Augment the Power for Predicting Plant Protein Subcellular Localization," PLOS ONE, Public Library of Science, vol. 5(6), pages 1-11, June.
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    1. Huazhen Wang & Xin Liu & Bing Lv & Fan Yang & Yanzhu Hong, 2014. "Reliable Multi-Label Learning via Conformal Predictor and Random Forest for Syndrome Differentiation of Chronic Fatigue in Traditional Chinese Medicine," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-14, June.
    2. Shibiao Wan & Man-Wai Mak & Sun-Yuan Kung, 2014. "HybridGO-Loc: Mining Hybrid Features on Gene Ontology for Predicting Subcellular Localization of Multi-Location Proteins," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-12, March.

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