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Ghrelin Treatment of Cachectic Patients with Chronic Obstructive Pulmonary Disease: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

Author

Listed:
  • Keisuke Miki
  • Ryoji Maekura
  • Noritoshi Nagaya
  • Masamitsu Nakazato
  • Hiroshi Kimura
  • Shinsuke Murakami
  • Shunsuke Ohnishi
  • Toru Hiraga
  • Mari Miki
  • Seigo Kitada
  • Kenji Yoshimura
  • Yoshitaka Tateishi
  • Yasuji Arimura
  • Nobuhiro Matsumoto
  • Masanori Yoshikawa
  • Kenichi Yamahara
  • Kenji Kangawa

Abstract

Background: Pulmonary cachexia is common in advanced chronic obstructive pulmonary disease (COPD), culminating in exercise intolerance and a poor prognosis. Ghrelin is a novel growth hormone (GH)-releasing peptide with GH-independent effects. The efficacy and safety of adding ghrelin to pulmonary rehabilitation (PR) in cachectic COPD patients were investigated. Methodology/Principal Findings: In a multicenter, randomized, double-blind, placebo-controlled trial, 33 cachectic COPD patients were randomly assigned PR with intravenous ghrelin (2 µg/kg) or placebo twice daily for 3 weeks in hospital. The primary outcomes were changes in 6-min walk distance (6-MWD) and the St. George Respiratory Questionnaire (SGRQ) score. Secondary outcomes included changes in the Medical Research Council (MRC) scale, and respiratory muscle strength. At pre-treatment, serum GH levels were increased from baseline levels by a single dose of ghrelin (mean change, +46.5 ng/ml; between-group p

Suggested Citation

  • Keisuke Miki & Ryoji Maekura & Noritoshi Nagaya & Masamitsu Nakazato & Hiroshi Kimura & Shinsuke Murakami & Shunsuke Ohnishi & Toru Hiraga & Mari Miki & Seigo Kitada & Kenji Yoshimura & Yoshitaka Tate, 2012. "Ghrelin Treatment of Cachectic Patients with Chronic Obstructive Pulmonary Disease: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-10, May.
    • Handle: RePEc:plo:pone00:0035708
    DOI: 10.1371/journal.pone.0035708
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