IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v407y2000i6806d10.1038_35038090.html
   My bibliography  Save this article

Ghrelin induces adiposity in rodents

Author

Listed:
  • Matthias Tschöp

    (Endocrine Research and BioResearch Technologies & Proteins Lilly Research Laboratories, Lilly Corporate Center)

  • David L. Smiley

    (Endocrine Research and BioResearch Technologies & Proteins Lilly Research Laboratories, Lilly Corporate Center)

  • Mark L. Heiman

    (Endocrine Research and BioResearch Technologies & Proteins Lilly Research Laboratories, Lilly Corporate Center)

Abstract

The discovery of the peptide hormone ghrelin, an endogenous ligand for the growth hormone secretagogue (GHS) receptor1,2, yielded the surprising result3 that the principal site of ghrelin synthesis is the stomach and not the hypothalamus. Although ghrelin is likely to regulate pituitary growth hormone (GH) secretion3,4 along with GH-releasing hormone and somatostatin, GHS receptors have also been identified on hypothalamic neurons5 and in the brainstem6. Apart from potential paracrine effects, ghrelin may thus offer an endocrine link between stomach, hypothalamus and pituitary, suggesting an involvement in regulation of energy balance. Here we show that peripheral daily administration of ghrelin caused weight gain by reducing fat utilization in mice and rats. Intracerebroventricular administration of ghrelin generated a dose-dependent increase in food intake and body weight. Rat serum ghrelin concentrations were increased by fasting and were reduced by re-feeding or oral glucose administration, but not by water ingestion. We propose that ghrelin, in addition to its role in regulating GH secretion, signals the hypothalamus when an increase in metabolic efficiency is necessary.

Suggested Citation

  • Matthias Tschöp & David L. Smiley & Mark L. Heiman, 2000. "Ghrelin induces adiposity in rodents," Nature, Nature, vol. 407(6806), pages 908-913, October.
    • Handle: RePEc:nat:nature:v:407:y:2000:i:6806:d:10.1038_35038090
    DOI: 10.1038/35038090
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35038090
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/35038090?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Andrea Palermo & Dario Tuccinardi & Giuseppe Defeudis & Mikiko Watanabe & Luca D’Onofrio & Angelo Lauria Pantano & Nicola Napoli & Paolo Pozzilli & Silvia Manfrini, 2016. "BMI and BMD: The Potential Interplay between Obesity and Bone Fragility," IJERPH, MDPI, vol. 13(6), pages 1-30, May.
    2. Amany M Basuny & Moustafa A AboelAnin & Eman A Hamed, 2020. "Structure and Physiological Functions of Ghrelin," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 31(2), pages 24085-24092, October.
    3. Nan Li, 2016. "Ghrelin/GHS-R1a Signaling Modulates Emotional Learning and Memory," International Journal of Sciences, Office ijSciences, vol. 5(03), pages 160-163, March.
    4. Michelle L Johnson & M Jill Saffrey & Victoria J Taylor, 2016. "Plasma Ghrelin Concentrations Were Altered with Oestrous Cycle Stage and Increasing Age in Reproductively Competent Wistar Females," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-12, November.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:407:y:2000:i:6806:d:10.1038_35038090. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.