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Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation

Author

Listed:
  • Sarah M. Mohr

    (Yale University School of Medicine
    Yale University School of Medicine
    Yale University School of Medicine)

  • Rafael Dai Pra

    (Yale University School of Medicine
    Yale University School of Medicine
    Yale University School of Medicine)

  • Maryann P. Platt

    (Yale University School of Medicine
    Yale University School of Medicine
    Yale University School of Medicine)

  • Viktor V. Feketa

    (Yale University School of Medicine
    Yale University School of Medicine
    Yale University School of Medicine)

  • Marya Shanabrough

    (Yale University School of Medicine)

  • Luis Varela

    (Yale University School of Medicine
    Laboratory of Glia-Neuron Interactions in the Control of Hunger. Achucarro_Basque Center for Neuroscience
    Basque Foundation for Science)

  • Ashley Kristant

    (Yale University School of Medicine)

  • Haoran Cao

    (Yale University School of Medicine
    Yale University School of Medicine
    Yale University School of Medicine)

  • Dana K. Merriman

    (University of Wisconsin-Oshkosh)

  • Tamas L. Horvath

    (Yale University School of Medicine
    Laboratory of Glia-Neuron Interactions in the Control of Hunger. Achucarro_Basque Center for Neuroscience
    Basque Foundation for Science)

  • Sviatoslav N. Bagriantsev

    (Yale University School of Medicine)

  • Elena O. Gracheva

    (Yale University School of Medicine
    Yale University School of Medicine
    Yale University School of Medicine)

Abstract

Mammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal physiological functions, but the mechanisms underlying these adaptations are poorly understood. The hibernation cycle of thirteen-lined ground squirrels (Ictidomys tridecemlineatus) lasts for 5–7 months and comprises weeks of hypometabolic, hypothermic torpor interspersed with 24–48-h periods of an active-like interbout arousal (IBA) state. We show that ground squirrels, who endure the entire hibernation season without food, have negligible hunger during IBAs. These squirrels exhibit reversible inhibition of the hypothalamic feeding center, such that hypothalamic arcuate nucleus neurons exhibit reduced sensitivity to the orexigenic and anorexigenic effects of ghrelin and leptin, respectively. However, hypothalamic infusion of thyroid hormone during an IBA is sufficient to rescue hibernation anorexia. Our results reveal that thyroid hormone deficiency underlies hibernation anorexia and demonstrate the functional flexibility of the hypothalamic feeding center.

Suggested Citation

  • Sarah M. Mohr & Rafael Dai Pra & Maryann P. Platt & Viktor V. Feketa & Marya Shanabrough & Luis Varela & Ashley Kristant & Haoran Cao & Dana K. Merriman & Tamas L. Horvath & Sviatoslav N. Bagriantsev , 2024. "Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49996-2
    DOI: 10.1038/s41467-024-49996-2
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    References listed on IDEAS

    as
    1. Masayasu Kojima & Hiroshi Hosoda & Yukari Date & Masamitsu Nakazato & Hisayuki Matsuo & Kenji Kangawa, 1999. "Ghrelin is a growth-hormone-releasing acylated peptide from stomach," Nature, Nature, vol. 402(6762), pages 656-660, December.
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