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Ghrelin/GHS-R1a Signaling Modulates Emotional Learning and Memory

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  • Nan Li

Abstract

The amygdala complex is strongly involved in the formation of emotional memories, and GHS-R1a was found to be highly expressed in the lateral amygdala versus the central nucleus. Our previous study showed that micro-injection of ghrelin, the natural ligand of GHS-R1a, into lateral amygdala impairs memory in mice. Consistently, GHS-R1a KO mice shows enhanced memory. To explore the cellular mechanism mediating the effect of GHS-R1a signaling on emotional memory, we recorded spontaneous IPSCs and EPSCs in GHS-R1a KO and WT BL6 control mice. We found that GHS-R1a KO mice exhibited higher amplitude of IPSCs compared to that of control mice, while the EPSC We found that GHS-R1a KO mice exhibited higher frequency compared to that of control mice.

Suggested Citation

  • Nan Li, 2016. "Ghrelin/GHS-R1a Signaling Modulates Emotional Learning and Memory," International Journal of Sciences, Office ijSciences, vol. 5(03), pages 160-163, March.
    • Handle: RePEc:adm:journl:v:5:y:2016:i:3:p:160-163
    DOI: 10.18483/ijSci.993
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    1. Matthias Tschöp & David L. Smiley & Mark L. Heiman, 2000. "Ghrelin induces adiposity in rodents," Nature, Nature, vol. 407(6806), pages 908-913, October.
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    More about this item

    Keywords

    Ghrelin; GHS-R1a; emotional learning ; emotional memory;
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