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Serum Ghrelin Levels in Saudi Obese Asthmatic School-Children—Correlation with Interleukin-4, Interleukin-5, and Interleukin-21

Author

Listed:
  • Mohammed Saeed Al-Ayed

    (Departments of Pediatrics, College of Medicine, Najran University, Najran P.O. Box 1988, Saudi Arabia)

  • Khaled Sadeq Al-Shaibari

    (Departments of Pediatrics, College of Medicine, Najran University, Najran P.O. Box 1988, Saudi Arabia)

  • Dhafer Alshehri

    (Departments of Pediatrics, College of Medicine, Najran University, Najran P.O. Box 1988, Saudi Arabia)

  • Mohammed Jamaan Alzahrani

    (Departments of Pediatrics, College of Medicine, Najran University, Najran P.O. Box 1988, Saudi Arabia)

  • Iman Nasser

    (Departments of Pediatrics, College of Medicine, Najran University, Najran P.O. Box 1988, Saudi Arabia)

  • Hamdan Saad Alaamri

    (Ministry of Defense, Armed Forces Medical Services, Najran, Saudi Arabia)

  • Wed Ahmad Alaseeri

    (Ministry of Health, Najran 11176, Saudi Arabia)

  • Ahmed A. Mahfouz

    (Department of Family and Community Medicine, College of Medicine, King Khalid University, Abha 62529, Saudi Arabia)

  • Saeed Ali Alsareii

    (Department of Surgery, College of Medicine, Najran University, Najran P.O. Box 1988, Saudi Arabia)

  • Ahmed Morad Asaad

    (Department of Microbiology, Zagazig University, ‎Ash Sharqiyah 44519, Egypt)

  • Aamir Magzoub

    (Department of Physiology, College of Medicine, Najran University, Najran P.O. Box 1988, Saudi Arabia)

  • Mohammed Ansar Qureshi

    (Department of Microbiology, College of Medicine, Najran University, Najran P.O. Box 1988, Saudi Arabia)

  • Ehab Elagab

    (Department of Pathology, College of Medicine, Najran University, Najran P.O. Box 1988, Saudi Arabia)

  • Elhashimi Eltayb Hassan

    (Department of Clinical Biochemistry, College of Applied Medical Sciences, Najran University, Najran P.O. Box 1988, Saudi Arabia)

  • Mohammed Helmy Faris Shalayel

    (University of Hafr Al-Batin, Hafr Albatin 39524, Saudi Arabia)

Abstract

Ghrelin is a peptide hormone with direct or indirect effects on obesity and asthma. More data are required to understand the effect of ghrelin on the control and pathogenesis of these diseases. The aim of this study was to evaluate ghrelin levels in selected groups of children to identify the association between serum ghrelin, obesity, and the severity of asthma. The study included 401 school children selected from the Najran area and grouped into non-obese asthmatics, obese asthmatics, obese non-asthmatics and controls (non-obese non-asthmatics). Blood levels of ghrelin, interleukin (IL)-4, IL-5 and IL-21 were determined by ELISA. The mean ghrelin values were insignificantly increased in obese children compared with non-obese children. The highest blood ghrelin values were in the non-obese asthmatic group. Serum ghrelin, IL-4 and IL-21 levels were significantly increased in asthmatic children compared with non-asthmatic children ( p < 0.05), and there were significant positive correlations between ghrelin and IL-4, IL-5, and IL-21 in asthmatic children. Furthermore, ghrelin, IL-4, and IL-21 levels were significantly higher in uncontrolled asthmatics compared with controlled-asthmatic children ( p < 0.05). Asthma was the only significant risk factor for high ghrelin values. This study provides evidence supporting the anti-inflammatory role of ghrelin in the pathogenesis of asthma. Asthma might be considered as an important determinant of high ghrelin values in children.

Suggested Citation

  • Mohammed Saeed Al-Ayed & Khaled Sadeq Al-Shaibari & Dhafer Alshehri & Mohammed Jamaan Alzahrani & Iman Nasser & Hamdan Saad Alaamri & Wed Ahmad Alaseeri & Ahmed A. Mahfouz & Saeed Ali Alsareii & Ahmed, 2020. "Serum Ghrelin Levels in Saudi Obese Asthmatic School-Children—Correlation with Interleukin-4, Interleukin-5, and Interleukin-21," IJERPH, MDPI, vol. 17(5), pages 1-11, March.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:5:p:1656-:d:328174
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    References listed on IDEAS

    as
    1. Masayasu Kojima & Hiroshi Hosoda & Yukari Date & Masamitsu Nakazato & Hisayuki Matsuo & Kenji Kangawa, 1999. "Ghrelin is a growth-hormone-releasing acylated peptide from stomach," Nature, Nature, vol. 402(6762), pages 656-660, December.
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