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A Multi-Functional Synthetic Gene Network: A Frequency Multiplier, Oscillator and Switch

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  • Oliver Purcell
  • Mario di Bernardo
  • Claire S Grierson
  • Nigel J Savery

Abstract

We present the design and analysis of a synthetic gene network that performs frequency multiplication. It takes oscillatory transcription factor concentrations, such as those produced from the currently available genetic oscillators, as an input, and produces oscillations with half the input frequency as an output. Analysis of the bifurcation structure also reveals novel, programmable multi-functionality; in addition to functioning as a frequency multiplier, the network is able to function as a switch or an oscillator, depending on the temporal nature of the input. Multi-functionality is often observed in neuronal networks, where it is suggested to allow for the efficient coordination of different responses. This network represents a significant theoretical addition that extends the capabilities of synthetic gene networks.

Suggested Citation

  • Oliver Purcell & Mario di Bernardo & Claire S Grierson & Nigel J Savery, 2011. "A Multi-Functional Synthetic Gene Network: A Frequency Multiplier, Oscillator and Switch," PLOS ONE, Public Library of Science, vol. 6(2), pages 1-12, February.
    • Handle: RePEc:plo:pone00:0016140
    DOI: 10.1371/journal.pone.0016140
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    References listed on IDEAS

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    1. Eileen Fung & Wilson W. Wong & Jason K. Suen & Thomas Bulter & Sun-gu Lee & James C. Liao, 2005. "A synthetic gene–metabolic oscillator," Nature, Nature, vol. 435(7038), pages 118-122, May.
    2. Marcel Tigges & Tatiana T. Marquez-Lago & Jörg Stelling & Martin Fussenegger, 2009. "A tunable synthetic mammalian oscillator," Nature, Nature, vol. 457(7227), pages 309-312, January.
    3. Jesse Stricker & Scott Cookson & Matthew R. Bennett & William H. Mather & Lev S. Tsimring & Jeff Hasty, 2008. "A fast, robust and tunable synthetic gene oscillator," Nature, Nature, vol. 456(7221), pages 516-519, November.
    4. Michael B. Elowitz & Stanislas Leibler, 2000. "A synthetic oscillatory network of transcriptional regulators," Nature, Nature, vol. 403(6767), pages 335-338, January.
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    Cited by:

    1. Jean Peccoud & Mark Isalan, 2012. "The PLOS ONE Synthetic Biology Collection: Six Years and Counting," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-7, August.

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