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A tunable synthetic mammalian oscillator

Author

Listed:
  • Marcel Tigges

    (ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland)

  • Tatiana T. Marquez-Lago

    (ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland
    Institute of Computational Science and,
    Swiss Institute of Bioinformatics, ETH Zurich, CH-8092 Zurich, Switzerland)

  • Jörg Stelling

    (ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland
    Institute of Computational Science and,
    Swiss Institute of Bioinformatics, ETH Zurich, CH-8092 Zurich, Switzerland)

  • Martin Fussenegger

    (ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland)

Abstract

An around-the-clock synthetic gene circuit Synthetic gene circuits producing oscillating outputs have been developed only in bacteria, and it has been difficult to make them reliable even there. Tigges et al. have now developed a synthetic sense–antisense circuit in mammalian cells that produces autonomous, self-sustained and tunable cyclic gene expression. This synthetic mammalian clock will be of use in the study of oscillations in mammalian cells, and may improve our understanding of the circadian clock and associated pathologies.

Suggested Citation

  • Marcel Tigges & Tatiana T. Marquez-Lago & Jörg Stelling & Martin Fussenegger, 2009. "A tunable synthetic mammalian oscillator," Nature, Nature, vol. 457(7227), pages 309-312, January.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7227:d:10.1038_nature07616
    DOI: 10.1038/nature07616
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    Citations

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    Cited by:

    1. Shunsuke Kawasaki & Hiroki Ono & Moe Hirosawa & Takeru Kuwabara & Shunsuke Sumi & Suji Lee & Knut Woltjen & Hirohide Saito, 2023. "Programmable mammalian translational modulators by CRISPR-associated proteins," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Lukas Aufinger & Johann Brenner & Friedrich C. Simmel, 2022. "Complex dynamics in a synchronized cell-free genetic clock," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    3. Betz, Ulrich A.K. & Arora, Loukik & Assal, Reem A. & Azevedo, Hatylas & Baldwin, Jeremy & Becker, Michael S. & Bostock, Stefan & Cheng, Vinton & Egle, Tobias & Ferrari, Nicola & Schneider-Futschik, El, 2023. "Game changers in science and technology - now and beyond," Technological Forecasting and Social Change, Elsevier, vol. 193(C).
    4. Sara Hooshangi & William E Bentley, 2011. "LsrR Quorum Sensing “Switch” Is Revealed by a Bottom-Up Approach," PLOS Computational Biology, Public Library of Science, vol. 7(9), pages 1-11, September.
    5. Kaslik, Eva & Rădulescu, Ileana Rodica, 2022. "Stability and bifurcations in fractional-order gene regulatory networks," Applied Mathematics and Computation, Elsevier, vol. 421(C).
    6. Lucia Marucci & David A W Barton & Irene Cantone & Maria Aurelia Ricci & Maria Pia Cosma & Stefania Santini & Diego di Bernardo & Mario di Bernardo, 2009. "How to Turn a Genetic Circuit into a Synthetic Tunable Oscillator, or a Bistable Switch," PLOS ONE, Public Library of Science, vol. 4(12), pages 1-10, December.
    7. Miles Miller & Marc Hafner & Eduardo Sontag & Noah Davidsohn & Sairam Subramanian & Priscilla E M Purnick & Douglas Lauffenburger & Ron Weiss, 2012. "Modular Design of Artificial Tissue Homeostasis: Robust Control through Synthetic Cellular Heterogeneity," PLOS Computational Biology, Public Library of Science, vol. 8(7), pages 1-18, July.
    8. Zhou, Peipei & Cai, Shuiming & Liu, Zengrong & Chen, Luonan & Wang, Ruiqi, 2013. "Coupling switches and oscillators as a means to shape cellular signals in biomolecular systems," Chaos, Solitons & Fractals, Elsevier, vol. 50(C), pages 115-126.
    9. Astakhov, Sergey & Astakhov, Oleg & Fadeeva, Natalia & Astakhov, Vladimir, 2021. "Multistability, quasiperiodicity and chaos in a self-oscillating ring dynamical system with three degrees of freedom based on the van der Pol generator," Chaos, Solitons & Fractals, Elsevier, vol. 148(C).

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