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Revisiting an Old Riddle: What Determines Genetic Diversity Levels within Species?

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Listed:
  • Ellen M Leffler
  • Kevin Bullaughey
  • Daniel R Matute
  • Wynn K Meyer
  • Laure Ségurel
  • Aarti Venkat
  • Peter Andolfatto
  • Molly Przeworski

Abstract

With the recent revolution in sequencing, we revisit the unresolved question of what influences the range and values of genetic diversity across taxa. Understanding why some species have more genetic diversity than others is central to the study of ecology and evolution, and carries potentially important implications for conservation biology. Yet not only does this question remain unresolved, it has largely fallen into disregard. With the rapid decrease in sequencing costs, we argue that it is time to revive it.

Suggested Citation

  • Ellen M Leffler & Kevin Bullaughey & Daniel R Matute & Wynn K Meyer & Laure Ségurel & Aarti Venkat & Peter Andolfatto & Molly Przeworski, 2012. "Revisiting an Old Riddle: What Determines Genetic Diversity Levels within Species?," PLOS Biology, Public Library of Science, vol. 10(9), pages 1-9, September.
  • Handle: RePEc:plo:pbio00:1001388
    DOI: 10.1371/journal.pbio.1001388
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    References listed on IDEAS

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    1. Heng Li & Richard Durbin, 2011. "Inference of human population history from individual whole-genome sequences," Nature, Nature, vol. 475(7357), pages 493-496, July.
    2. Brian J. O’Roak & Laura Vives & Santhosh Girirajan & Emre Karakoc & Niklas Krumm & Bradley P. Coe & Roie Levy & Arthur Ko & Choli Lee & Joshua D. Smith & Emily H. Turner & Ian B. Stanaway & Benjamin V, 2012. "Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations," Nature, Nature, vol. 485(7397), pages 246-250, May.
    3. Eline D. Lorenzen & David Nogués-Bravo & Ludovic Orlando & Jaco Weinstock & Jonas Binladen & Katharine A. Marske & Andrew Ugan & Michael K. Borregaard & M. Thomas P. Gilbert & Rasmus Nielsen & Simon Y, 2011. "Species-specific responses of Late Quaternary megafauna to climate and humans," Nature, Nature, vol. 479(7373), pages 359-364, November.
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