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Inference of human population history from individual whole-genome sequences

Author

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  • Heng Li

    (The Wellcome Trust Sanger Institute
    Broad Institute of Harvard and MIT)

  • Richard Durbin

    (The Wellcome Trust Sanger Institute)

Abstract

Human population in the genes The history of human population size is important to understanding human evolution. Heng Li and Richard Durbin use complete genome sequences from Chinese, Korean, European and Yoruban (West African) individuals to estimate population sizes between 10,000 and 1 million years ago. They infer that European and Chinese populations had very similar size histories until about 10,000–20,000 years ago. The European, Chinese and African populations all had an elevated effective population between 60,000 and 250,000 years ago. Genomic analysis suggests that the differentiation of genetically modern humans may have started as early as 100,000–120,000 years ago.

Suggested Citation

  • Heng Li & Richard Durbin, 2011. "Inference of human population history from individual whole-genome sequences," Nature, Nature, vol. 475(7357), pages 493-496, July.
    • Handle: RePEc:nat:nature:v:475:y:2011:i:7357:d:10.1038_nature10231
    DOI: 10.1038/nature10231
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