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Evolution of resistance to COVID-19 vaccination with dynamic social distancing

Author

Listed:
  • Gabriela Lobinska

    (Weizmann Institute of Science)

  • Ady Pauzner

    (Tel Aviv University)

  • Arne Traulsen

    (Max-Planck-Institute for Evolutionary Biology)

  • Yitzhak Pilpel

    (Weizmann Institute of Science)

  • Martin A. Nowak

    (Harvard University
    Harvard University)

Abstract

The greatest hope for a return to normalcy following the COVID-19 pandemic is worldwide vaccination. Yet, a relaxation of social distancing that allows increased transmissibility, coupled with selection pressure due to vaccination, will probably lead to the emergence of vaccine resistance. We analyse the evolutionary dynamics of COVID-19 in the presence of dynamic contact reduction and in response to vaccination. We use infection and vaccination data from six different countries. We show that under slow vaccination, resistance is very likely to appear even if social distancing is maintained. Under fast vaccination, the emergence of mutants can be prevented if social distancing is maintained during vaccination. We analyse multiple human factors that affect the evolutionary potential of the virus, including the extent of dynamic social distancing, vaccination campaigns, vaccine design, boosters and vaccine hesitancy. We provide guidelines for policies that aim to minimize the probability of emergence of vaccine-resistant variants.

Suggested Citation

  • Gabriela Lobinska & Ady Pauzner & Arne Traulsen & Yitzhak Pilpel & Martin A. Nowak, 2022. "Evolution of resistance to COVID-19 vaccination with dynamic social distancing," Nature Human Behaviour, Nature, vol. 6(2), pages 193-206, February.
    • Handle: RePEc:nat:nathum:v:6:y:2022:i:2:d:10.1038_s41562-021-01281-8
    DOI: 10.1038/s41562-021-01281-8
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    1. Jemma L. Geoghegan & Xiaoyun Ren & Matthew Storey & James Hadfield & Lauren Jelley & Sarah Jefferies & Jill Sherwood & Shevaun Paine & Sue Huang & Jordan Douglas & Fábio K. Mendes & Andrew Sporle & Mi, 2020. "Genomic epidemiology reveals transmission patterns and dynamics of SARS-CoV-2 in Aotearoa New Zealand," Nature Communications, Nature, vol. 11(1), pages 1-7, December.
    2. Juan Yang & Valentina Marziano & Xiaowei Deng & Giorgio Guzzetta & Juanjuan Zhang & Filippo Trentini & Jun Cai & Piero Poletti & Wen Zheng & Wei Wang & Qianhui Wu & Zeyao Zhao & Kaige Dong & Guangjie , 2021. "Despite vaccination, China needs non-pharmaceutical interventions to prevent widespread outbreaks of COVID-19 in 2021," Nature Human Behaviour, Nature, vol. 5(8), pages 1009-1020, August.
    3. Pengfei Wang & Manoj S. Nair & Lihong Liu & Sho Iketani & Yang Luo & Yicheng Guo & Maple Wang & Jian Yu & Baoshan Zhang & Peter D. Kwong & Barney S. Graham & John R. Mascola & Jennifer Y. Chang & Mich, 2021. "Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7," Nature, Nature, vol. 593(7857), pages 130-135, May.
    4. Manon Ragonnet-Cronin & Olivia Boyd & Lily Geidelberg & David Jorgensen & Fabricia F. Nascimento & Igor Siveroni & Robert A. Johnson & Marc Baguelin & Zulma M. Cucunubá & Elita Jauneikaite & Swapnil M, 2021. "Genetic evidence for the association between COVID-19 epidemic severity and timing of non-pharmaceutical interventions," Nature Communications, Nature, vol. 12(1), pages 1-7, December.
    5. Andrey B. Komissarov & Ksenia R. Safina & Sofya K. Garushyants & Artem V. Fadeev & Mariia V. Sergeeva & Anna A. Ivanova & Daria M. Danilenko & Dmitry Lioznov & Olga V. Shneider & Nikita Shvyrev & Vadi, 2021. "Genomic epidemiology of the early stages of the SARS-CoV-2 outbreak in Russia," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    6. Houriiyah Tegally & Eduan Wilkinson & Marta Giovanetti & Arash Iranzadeh & Vagner Fonseca & Jennifer Giandhari & Deelan Doolabh & Sureshnee Pillay & Emmanuel James San & Nokukhanya Msomi & Koleka Mlis, 2021. "Detection of a SARS-CoV-2 variant of concern in South Africa," Nature, Nature, vol. 592(7854), pages 438-443, April.
    7. Rachel E. Baker & Wenchang Yang & Gabriel A. Vecchi & C. Jessica E. Metcalf & Bryan T. Grenfell, 2021. "Assessing the influence of climate on wintertime SARS-CoV-2 outbreaks," Nature Communications, Nature, vol. 12(1), pages 1-7, December.
    8. Simón A. Rella & Yuliya A. Kulikova & Emmanouil T. Dermitzakis & Fyodor A. Kondrashov, 2021. "Rates of SARS-COV-2 transmission and vaccination impact the fate of vaccine-resistant strains," Working Papers 2129, Banco de España.
    9. João Viana & Christiaan H. Dorp & Ana Nunes & Manuel C. Gomes & Michiel Boven & Mirjam E. Kretzschmar & Marc Veldhoen & Ganna Rozhnova, 2021. "Controlling the pandemic during the SARS-CoV-2 vaccination rollout," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
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    1. Sebastian Contreras & Jonas Dehning & Viola Priesemann, 2022. "Describing a landscape we are yet discovering," AStA Advances in Statistical Analysis, Springer;German Statistical Society, vol. 106(3), pages 399-402, September.
    2. Xiyun Zhang & Zhongyuan Ruan & Muhua Zheng & Jie Zhou & Stefano Boccaletti & Baruch Barzel, 2022. "Epidemic spreading under mutually independent intra- and inter-host pathogen evolution," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Nie, Yanyi & Zhong, Xiaoni & Lin, Tao & Wang, Wei, 2023. "Pathogen diversity in meta-population networks," Chaos, Solitons & Fractals, Elsevier, vol. 166(C).

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