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Updated vaccine protects against SARS-CoV-2 variants including Omicron (B.1.1.529) and prevents transmission in hamsters

Author

Listed:
  • Sapna Sharma

    (Rega Institute, Laboratory of Virology, Molecular Vaccinology and Vaccine Discovery)

  • Thomas Vercruysse

    (Rega Institute, Laboratory of Virology and Chemotherapy, Translational Platform Virology and Chemotherapy)

  • Lorena Sanchez-Felipe

    (Rega Institute, Laboratory of Virology, Molecular Vaccinology and Vaccine Discovery)

  • Winnie Kerstens

    (Rega Institute, Laboratory of Virology and Chemotherapy, Translational Platform Virology and Chemotherapy)

  • Madina Rasulova

    (Rega Institute, Laboratory of Virology and Chemotherapy, Translational Platform Virology and Chemotherapy)

  • Lindsey Bervoets

    (Rega Institute, Laboratory of Virology, Molecular Vaccinology and Vaccine Discovery)

  • Carolien Keyzer

    (Rega Institute, Laboratory of Virology, Molecular Vaccinology and Vaccine Discovery)

  • Rana Abdelnabi

    (Rega Institute, Laboratory of Virology, Molecular Vaccinology and Vaccine Discovery)

  • Caroline S. Foo

    (Rega Institute, Laboratory of Virology, Molecular Vaccinology and Vaccine Discovery)

  • Viktor Lemmens

    (Rega Institute, Laboratory of Virology, Molecular Vaccinology and Vaccine Discovery)

  • Dominique Looveren

    (Rega Institute, Laboratory of Virology and Chemotherapy, Translational Platform Virology and Chemotherapy)

  • Piet Maes

    (Rega Institute, Laboratory of Clinical and Epidemiological Virology, Zoonotic Infectious Diseases Unit)

  • Guy Baele

    (Rega Institute, Laboratory of Clinical and Epidemiological Virology, Evolutionary and Computational Virology)

  • Birgit Weynand

    (Translational Cell and Tissue Research)

  • Philippe Lemey

    (Rega Institute, Laboratory of Clinical and Epidemiological Virology, Evolutionary and Computational Virology)

  • Johan Neyts

    (Rega Institute, Laboratory of Virology, Molecular Vaccinology and Vaccine Discovery
    Global Virus Network (GVN))

  • Hendrik Jan Thibaut

    (Rega Institute, Laboratory of Virology and Chemotherapy, Translational Platform Virology and Chemotherapy)

  • Kai Dallmeier

    (Rega Institute, Laboratory of Virology, Molecular Vaccinology and Vaccine Discovery)

Abstract

Current COVID-19 vaccines are based on prototypic spike sequences from ancestral 2019 SARS-CoV-2 strains. However, the ongoing pandemic is fueled by variants of concern (VOC) escaping vaccine-mediated protection. Here we demonstrate how immunization in hamsters using prototypic spike expressed from yellow fever 17D (YF17D) as vector blocks ancestral virus (B lineage) and VOC Alpha (B.1.1.7) yet fails to fully protect from Beta (B.1.351). However, the same YF17D vectored vaccine candidate with an evolved antigen induced considerably improved neutralizing antibody responses against VOCs Beta, Gamma (P.1) and the recently predominant Omicron (B.1.1.529), while maintaining immunogenicity against ancestral virus and VOC Delta (B.1.617.2). Thus vaccinated animals resisted challenge by all VOCs, including vigorous high titre exposure to the most difficult to cover Beta, Delta and Omicron variants, eliminating detectable virus and markedly improving lung pathology. Finally, vaccinated hamsters did not transmit Delta variant to non-vaccinated cage mates. Overall, our data illustrate how current first-generation COVID-19 vaccines may need to be updated to maintain efficacy against emerging VOCs and their spread at community level.

Suggested Citation

  • Sapna Sharma & Thomas Vercruysse & Lorena Sanchez-Felipe & Winnie Kerstens & Madina Rasulova & Lindsey Bervoets & Carolien Keyzer & Rana Abdelnabi & Caroline S. Foo & Viktor Lemmens & Dominique Loover, 2022. "Updated vaccine protects against SARS-CoV-2 variants including Omicron (B.1.1.529) and prevents transmission in hamsters," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34439-7
    DOI: 10.1038/s41467-022-34439-7
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    as
    1. Jarek Juraszek & Lucy Rutten & Sven Blokland & Pascale Bouchier & Richard Voorzaat & Tina Ritschel & Mark J. G. Bakkers & Ludovic L. R. Renault & Johannes P. M. Langedijk, 2021. "Stabilizing the closed SARS-CoV-2 spike trimer," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
    2. Lorena Sanchez-Felipe & Thomas Vercruysse & Sapna Sharma & Ji Ma & Viktor Lemmens & Dominique Van Looveren & Mahadesh Prasad Arkalagud Javarappa & Robbert Boudewijns & Bert Malengier-Devlies & Laurens, 2021. "A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate," Nature, Nature, vol. 590(7845), pages 320-325, February.
    3. Pengfei Wang & Manoj S. Nair & Lihong Liu & Sho Iketani & Yang Luo & Yicheng Guo & Maple Wang & Jian Yu & Baoshan Zhang & Peter D. Kwong & Barney S. Graham & John R. Mascola & Jennifer Y. Chang & Mich, 2021. "Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7," Nature, Nature, vol. 593(7857), pages 130-135, May.
    4. Raquel Viana & Sikhulile Moyo & Daniel G. Amoako & Houriiyah Tegally & Cathrine Scheepers & Christian L. Althaus & Ugochukwu J. Anyaneji & Phillip A. Bester & Maciej F. Boni & Mohammed Chand & Wonderf, 2022. "Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa," Nature, Nature, vol. 603(7902), pages 679-686, March.
    5. Jingyou Yu & Lisa H. Tostanoski & Noe B. Mercado & Katherine McMahan & Jinyan Liu & Catherine Jacob-Dolan & Abishek Chandrashekar & Caroline Atyeo & David R. Martinez & Tochi Anioke & Esther A. Bondzi, 2021. "Protective efficacy of Ad26.COV2.S against SARS-CoV-2 B.1.351 in macaques," Nature, Nature, vol. 596(7872), pages 423-427, August.
    6. Dami A. Collier & Anna Marco & Isabella A. T. M. Ferreira & Bo Meng & Rawlings P. Datir & Alexandra C. Walls & Steven A. Kemp & Jessica Bassi & Dora Pinto & Chiara Silacci-Fregni & Siro Bianchi & M. A, 2021. "Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies," Nature, Nature, vol. 593(7857), pages 136-141, May.
    7. Peter J. Halfmann & Shun Iida & Kiyoko Iwatsuki-Horimoto & Tadashi Maemura & Maki Kiso & Suzanne M. Scheaffer & Tamarand L. Darling & Astha Joshi & Samantha Loeber & Gagandeep Singh & Stephanie L. Fos, 2022. "SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters," Nature, Nature, vol. 603(7902), pages 687-692, March.
    8. Jianying Liu & Yang Liu & Hongjie Xia & Jing Zou & Scott C. Weaver & Kena A. Swanson & Hui Cai & Mark Cutler & David Cooper & Alexander Muik & Kathrin U. Jansen & Ugur Sahin & Xuping Xie & Philip R. D, 2021. "BNT162b2-elicited neutralization of B.1.617 and other SARS-CoV-2 variants," Nature, Nature, vol. 596(7871), pages 273-275, August.
    9. Delphine Planas & Nell Saunders & Piet Maes & Florence Guivel-Benhassine & Cyril Planchais & Julian Buchrieser & William-Henry Bolland & Françoise Porrot & Isabelle Staropoli & Frederic Lemoine & Hélè, 2022. "Considerable escape of SARS-CoV-2 Omicron to antibody neutralization," Nature, Nature, vol. 602(7898), pages 671-675, February.
    10. Robbert Boudewijns & Hendrik Jan Thibaut & Suzanne J. F. Kaptein & Rong Li & Valentijn Vergote & Laura Seldeslachts & Johan Weyenbergh & Carolien Keyzer & Lindsey Bervoets & Sapna Sharma & Laurens Lie, 2020. "STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    11. Sin Fun Sia & Li-Meng Yan & Alex W. H. Chin & Kevin Fung & Ka-Tim Choy & Alvina Y. L. Wong & Prathanporn Kaewpreedee & Ranawaka A. P. M. Perera & Leo L. M. Poon & John M. Nicholls & Malik Peiris & Hui, 2020. "Pathogenesis and transmission of SARS-CoV-2 in golden hamsters," Nature, Nature, vol. 583(7818), pages 834-838, July.
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