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Quadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variants

Author

Listed:
  • Yin-Feng Kang

    (Sun Yat-sen University Cancer Center (SYSUCC), Sun Yat-sen University)

  • Cong Sun

    (Sun Yat-sen University Cancer Center (SYSUCC), Sun Yat-sen University)

  • Jing Sun

    (The First Affiliated Hospital of Guangzhou Medical University)

  • Chu Xie

    (Sun Yat-sen University Cancer Center (SYSUCC), Sun Yat-sen University)

  • Zhen Zhuang

    (The First Affiliated Hospital of Guangzhou Medical University)

  • Hui-Qin Xu

    (Southern University of Science and Technology)

  • Zheng Liu

    (Southern University of Science and Technology)

  • Yi-Hao Liu

    (The First Affiliated Hospital of Sun Yat-sen University
    The First Affiliated Hospital of Sun Yat-sen University)

  • Sui Peng

    (The First Affiliated Hospital of Sun Yat-sen University)

  • Run-Yu Yuan

    (Guangdong Provincial Center for Disease Control and Prevention)

  • Jin-Cun Zhao

    (The First Affiliated Hospital of Guangzhou Medical University
    Guangzhou Laboratory, Bio-island)

  • Mu-Sheng Zeng

    (Sun Yat-sen University Cancer Center (SYSUCC), Sun Yat-sen University
    Guangdong-Hong Kong Joint Laboratory for RNA Medicine)

Abstract

Emerging SARS-CoV-2 variants of concern (VOCs) harboring multiple mutations in the spike protein raise concerns on effectiveness of current vaccines that rely on the ancestral spike protein. Here, we design a quadrivalent mosaic nanoparticle vaccine displaying spike proteins from the SARS-CoV-2 prototype and 3 different VOCs. The mosaic nanoparticle elicits equivalent or superior neutralizing antibodies against variant strains in mice and non-human primates with only small reduction in neutralization titers against the ancestral strain. Notably, it provides protection against infection with prototype and B.1.351 strains in mice. These results provide a proof of principle for the development of multivalent vaccines against pandemic and potential pre-emergent SARS-CoV-2 variants.

Suggested Citation

  • Yin-Feng Kang & Cong Sun & Jing Sun & Chu Xie & Zhen Zhuang & Hui-Qin Xu & Zheng Liu & Yi-Hao Liu & Sui Peng & Run-Yu Yuan & Jin-Cun Zhao & Mu-Sheng Zeng, 2022. "Quadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variants," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30222-w
    DOI: 10.1038/s41467-022-30222-w
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