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Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines

Author

Listed:
  • Li Wang

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Markus H. Kainulainen

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Nannan Jiang

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Han Di

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Gaston Bonenfant

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Lisa Mills

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Michael Currier

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Punya Shrivastava-Ranjan

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Brenda M. Calderon

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Mili Sheth

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Brian R. Mann

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Jaber Hossain

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Xudong Lin

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Sandra Lester

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Elizabeth A. Pusch

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Joyce Jones

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Dan Cui

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Payel Chatterjee

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • M. Harley Jenks

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Esther K. Morantz

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Gloria P. Larson

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Masato Hatta

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Jennifer L. Harcourt

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Azaibi Tamin

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Yan Li

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Ying Tao

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Kun Zhao

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Kristine Lacek

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Ashley Burroughs

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Wei Wang

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Malania Wilson

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Terianne Wong

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • So Hee Park

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Suxiang Tong

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • John R. Barnes

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Mark W. Tenforde

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Wesley H. Self

    (Vanderbilt University)

  • Nathan I. Shapiro

    (Harvard University)

  • Matthew C. Exline

    (Ohio State University)

  • D. Clark Files

    (Wake Forest Baptist Medical Center)

  • Kevin W. Gibbs

    (Wake Forest Baptist Medical Center)

  • David N. Hager

    (Johns Hopkins University)

  • Manish Patel

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Alison L. Halpin

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Laura K. McMullan

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Justin S. Lee

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Hongjie Xia

    (University of Texas Medical Branch)

  • Xuping Xie

    (University of Texas Medical Branch)

  • Pei-Yong Shi

    (University of Texas Medical Branch)

  • C. Todd Davis

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Christina F. Spiropoulou

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Natalie J. Thornburg

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • M. Steven Oberste

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Vivien G. Dugan

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • David E. Wentworth

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

  • Bin Zhou

    (COVID-19 Emergency Response, Centers for Disease Control and Prevention)

Abstract

The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the emergence of new variant lineages that have exacerbated the COVID-19 pandemic. Some of those variants were designated as variants of concern/interest (VOC/VOI) by national or international authorities based on many factors including their potential impact on vaccine-mediated protection from disease. To ascertain and rank the risk of VOCs and VOIs, we analyze the ability of 14 variants (614G, Alpha, Beta, Gamma, Delta, Epsilon, Zeta, Eta, Theta, Iota, Kappa, Lambda, Mu, and Omicron) to escape from mRNA vaccine-induced antibodies. The variants show differential reductions in neutralization and replication by post-vaccination sera. Although the Omicron variant (BA.1, BA.1.1, and BA.2) shows the most escape from neutralization, sera collected after a third dose of vaccine (booster sera) retain moderate neutralizing activity against that variant. Therefore, vaccination remains an effective strategy during the COVID-19 pandemic.

Suggested Citation

  • Li Wang & Markus H. Kainulainen & Nannan Jiang & Han Di & Gaston Bonenfant & Lisa Mills & Michael Currier & Punya Shrivastava-Ranjan & Brenda M. Calderon & Mili Sheth & Brian R. Mann & Jaber Hossain &, 2022. "Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31929-6
    DOI: 10.1038/s41467-022-31929-6
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    References listed on IDEAS

    as
    1. Bin Zhou & Tran Thi Nhu Thao & Donata Hoffmann & Adriano Taddeo & Nadine Ebert & Fabien Labroussaa & Anne Pohlmann & Jacqueline King & Silvio Steiner & Jenna N. Kelly & Jasmine Portmann & Nico Joel Ha, 2021. "SARS-CoV-2 spike D614G change enhances replication and transmission," Nature, Nature, vol. 592(7852), pages 122-127, April.
    2. Houriiyah Tegally & Eduan Wilkinson & Marta Giovanetti & Arash Iranzadeh & Vagner Fonseca & Jennifer Giandhari & Deelan Doolabh & Sureshnee Pillay & Emmanuel James San & Nokukhanya Msomi & Koleka Mlis, 2021. "Detection of a SARS-CoV-2 variant of concern in South Africa," Nature, Nature, vol. 592(7854), pages 438-443, April.
    3. Jessica A. Plante & Yang Liu & Jianying Liu & Hongjie Xia & Bryan A. Johnson & Kumari G. Lokugamage & Xianwen Zhang & Antonio E. Muruato & Jing Zou & Camila R. Fontes-Garfias & Divya Mirchandani & Dio, 2021. "Spike mutation D614G alters SARS-CoV-2 fitness," Nature, Nature, vol. 592(7852), pages 116-121, April.
    4. Jessica A. Plante & Yang Liu & Jianying Liu & Hongjie Xia & Bryan A. Johnson & Kumari G. Lokugamage & Xianwen Zhang & Antonio E. Muruato & Jing Zou & Camila R. Fontes-Garfias & Divya Mirchandani & Dio, 2021. "Author Correction: Spike mutation D614G alters SARS-CoV-2 fitness," Nature, Nature, vol. 595(7865), pages 1-1, July.
    5. Katherine McMahan & Jingyou Yu & Noe B. Mercado & Carolin Loos & Lisa H. Tostanoski & Abishek Chandrashekar & Jinyan Liu & Lauren Peter & Caroline Atyeo & Alex Zhu & Esther A. Bondzie & Gabriel Dagott, 2021. "Correlates of protection against SARS-CoV-2 in rhesus macaques," Nature, Nature, vol. 590(7847), pages 630-634, February.
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    Cited by:

    1. Andrew P. Hederman & Harini Natarajan & Leo Heyndrickx & Kevin K. Ariën & Joshua A. Wiener & Peter F. Wright & Evan M. Bloch & Aaron A. R. Tobian & Andrew D. Redd & Joel N. Blankson & Amihai Rottenstr, 2023. "SARS-CoV-2 vaccination elicits broad and potent antibody effector functions to variants of concern in vulnerable populations," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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