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Peripheral contributions to resting state brain dynamics

Author

Listed:
  • Sarah Bricault

    (Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

  • Miranda Dawson

    (Massachusetts Institute of Technology)

  • Jiyoung Lee

    (Wellesley College)

  • Mitul Desai

    (Massachusetts Institute of Technology)

  • Miriam Schwalm

    (Massachusetts Institute of Technology)

  • Kevin Sunho Chung

    (Massachusetts Institute of Technology)

  • Elizabeth DeTienne

    (Massachusetts Institute of Technology)

  • Erinn Fagan

    (Massachusetts Institute of Technology)

  • Nan Li

    (Massachusetts Institute of Technology)

  • Andrew Becker

    (Massachusetts Institute of Technology)

  • Sureshkumar Muthupalani

    (Massachusetts Institute of Technology)

  • Jan-Philipp Fränken

    (University of Edinburgh)

  • Dimitris A. Pinotsis

    (University of London
    Massachusetts Institute of Technology)

  • Alan Jasanoff

    (Massachusetts Institute of Technology
    Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

Abstract

The correlational structure of brain activity dynamics in the absence of stimuli or behavior is often taken to reveal intrinsic properties of neural function. To test the limits of this assumption, we analyzed peripheral contributions to resting state activity measured by fMRI in unanesthetized, chemically immobilized male rats that emulate human neuroimaging conditions. We find that perturbation of somatosensory input channels modifies correlation strengths that relate somatosensory areas both to one another and to higher-order brain regions, despite the absence of ostensible stimuli or movements. Resting state effects are mediated by the same peripheral and thalamic structures that relay responses to overt sensory stimuli. The impact of basal peripheral input is reduced in a rat model of autism, which displays both lower somatosensory functional connectivity and insensitivity to vibrissa inactivation. These results demonstrate the influence of extrinsic influences on resting state brain phenotypes in health and disease.

Suggested Citation

  • Sarah Bricault & Miranda Dawson & Jiyoung Lee & Mitul Desai & Miriam Schwalm & Kevin Sunho Chung & Elizabeth DeTienne & Erinn Fagan & Nan Li & Andrew Becker & Sureshkumar Muthupalani & Jan-Philipp Frä, 2024. "Peripheral contributions to resting state brain dynamics," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-55064-6
    DOI: 10.1038/s41467-024-55064-6
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    References listed on IDEAS

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    1. Sami El-Boustani & B. Semihcan Sermet & Georgios Foustoukos & Tess B. Oram & Ofer Yizhar & Carl C. H. Petersen, 2020. "Anatomically and functionally distinct thalamocortical inputs to primary and secondary mouse whisker somatosensory cortices," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    2. Will D Penny & Klaas E Stephan & Jean Daunizeau & Maria J Rosa & Karl J Friston & Thomas M Schofield & Alex P Leff, 2010. "Comparing Families of Dynamic Causal Models," PLOS Computational Biology, Public Library of Science, vol. 6(3), pages 1-14, March.
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