IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-55064-6.html
   My bibliography  Save this article

Peripheral contributions to resting state brain dynamics

Author

Listed:
  • Sarah Bricault

    (Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

  • Miranda Dawson

    (Massachusetts Institute of Technology)

  • Jiyoung Lee

    (Wellesley College)

  • Mitul Desai

    (Massachusetts Institute of Technology)

  • Miriam Schwalm

    (Massachusetts Institute of Technology)

  • Kevin Sunho Chung

    (Massachusetts Institute of Technology)

  • Elizabeth DeTienne

    (Massachusetts Institute of Technology)

  • Erinn Fagan

    (Massachusetts Institute of Technology)

  • Nan Li

    (Massachusetts Institute of Technology)

  • Andrew Becker

    (Massachusetts Institute of Technology)

  • Sureshkumar Muthupalani

    (Massachusetts Institute of Technology)

  • Jan-Philipp Fränken

    (University of Edinburgh)

  • Dimitris A. Pinotsis

    (University of London
    Massachusetts Institute of Technology)

  • Alan Jasanoff

    (Massachusetts Institute of Technology
    Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

Abstract

The correlational structure of brain activity dynamics in the absence of stimuli or behavior is often taken to reveal intrinsic properties of neural function. To test the limits of this assumption, we analyzed peripheral contributions to resting state activity measured by fMRI in unanesthetized, chemically immobilized male rats that emulate human neuroimaging conditions. We find that perturbation of somatosensory input channels modifies correlation strengths that relate somatosensory areas both to one another and to higher-order brain regions, despite the absence of ostensible stimuli or movements. Resting state effects are mediated by the same peripheral and thalamic structures that relay responses to overt sensory stimuli. The impact of basal peripheral input is reduced in a rat model of autism, which displays both lower somatosensory functional connectivity and insensitivity to vibrissa inactivation. These results demonstrate the influence of extrinsic influences on resting state brain phenotypes in health and disease.

Suggested Citation

  • Sarah Bricault & Miranda Dawson & Jiyoung Lee & Mitul Desai & Miriam Schwalm & Kevin Sunho Chung & Elizabeth DeTienne & Erinn Fagan & Nan Li & Andrew Becker & Sureshkumar Muthupalani & Jan-Philipp Frä, 2024. "Peripheral contributions to resting state brain dynamics," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-55064-6
    DOI: 10.1038/s41467-024-55064-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-55064-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-55064-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Sami El-Boustani & B. Semihcan Sermet & Georgios Foustoukos & Tess B. Oram & Ofer Yizhar & Carl C. H. Petersen, 2020. "Anatomically and functionally distinct thalamocortical inputs to primary and secondary mouse whisker somatosensory cortices," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    2. Will D Penny & Klaas E Stephan & Jean Daunizeau & Maria J Rosa & Karl J Friston & Thomas M Schofield & Alex P Leff, 2010. "Comparing Families of Dynamic Causal Models," PLOS Computational Biology, Public Library of Science, vol. 6(3), pages 1-14, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Dimitrije Marković & Jan Gläscher & Peter Bossaerts & John O’Doherty & Stefan J Kiebel, 2015. "Modeling the Evolution of Beliefs Using an Attentional Focus Mechanism," PLOS Computational Biology, Public Library of Science, vol. 11(10), pages 1-34, October.
    2. L. Bonetti & G. Fernández-Rubio & F. Carlomagno & M. Dietz & D. Pantazis & P. Vuust & M. L. Kringelbach, 2024. "Spatiotemporal brain hierarchies of auditory memory recognition and predictive coding," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    3. Moe Okayasu & Tensei Inukai & Daiki Tanaka & Kaho Tsumura & Reiko Shintaki & Masaki Takeda & Kiyoshi Nakahara & Koji Jimura, 2023. "The Stroop effect involves an excitatory–inhibitory fronto-cerebellar loop," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    4. Andreea O Diaconescu & Christoph Mathys & Lilian A E Weber & Jean Daunizeau & Lars Kasper & Ekaterina I Lomakina & Ernst Fehr & Klaas E Stephan, 2014. "Inferring on the Intentions of Others by Hierarchical Bayesian Learning," PLOS Computational Biology, Public Library of Science, vol. 10(9), pages 1-19, September.
    5. Falk Lieder & Klaas E Stephan & Jean Daunizeau & Marta I Garrido & Karl J Friston, 2013. "A Neurocomputational Model of the Mismatch Negativity," PLOS Computational Biology, Public Library of Science, vol. 9(11), pages 1-14, November.
    6. Ahmed A Moustafa & Jony Sheynin & Catherine E Myers, 2015. "The Role of Informative and Ambiguous Feedback in Avoidance Behavior: Empirical and Computational Findings," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-21, December.
    7. Sam Gijsen & Miro Grundei & Robert T Lange & Dirk Ostwald & Felix Blankenburg, 2021. "Neural surprise in somatosensory Bayesian learning," PLOS Computational Biology, Public Library of Science, vol. 17(2), pages 1-36, February.
    8. repec:dau:papers:123456789/9572 is not listed on IDEAS
    9. Giovanni Leone & Charlotte Postel & Alison Mary & Florence Fraisse & Thomas Vallée & Fausto Viader & Vincent Sayette & Denis Peschanski & Jaques Dayan & Francis Eustache & Pierre Gagnepain, 2022. "Altered predictive control during memory suppression in PTSD," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    10. Amir Dezfouli & Bernard W Balleine, 2013. "Actions, Action Sequences and Habits: Evidence That Goal-Directed and Habitual Action Control Are Hierarchically Organized," PLOS Computational Biology, Public Library of Science, vol. 9(12), pages 1-14, December.
    11. Jean Daunizeau & Kerstin Preuschoff & Karl Friston & Klaas Stephan, 2011. "Optimizing Experimental Design for Comparing Models of Brain Function," PLOS Computational Biology, Public Library of Science, vol. 7(11), pages 1-18, November.
    12. Daniel G. Taub & Qiufen Jiang & Francesca Pietrafesa & Junfeng Su & Aloe Carroll & Caitlin Greene & Michael R. Blanchard & Aakanksha Jain & Mahmoud El-Rifai & Alexis Callen & Katherine Yager & Clara C, 2024. "The secondary somatosensory cortex gates mechanical and heat sensitivity," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    13. Fabien Vinckier & Lionel Rigoux & Irma T Kurniawan & Chen Hu & Sacha Bourgeois-Gironde & Jean Daunizeau & Mathias Pessiglione, 2019. "Sour grapes and sweet victories: How actions shape preferences," PLOS Computational Biology, Public Library of Science, vol. 15(1), pages 1-24, January.
    14. Pierre-Marie Gardères & Sébastien Gal & Charly Rousseau & Alexandre Mamane & Dan Alin Ganea & Florent Haiss, 2024. "Coexistence of state, choice, and sensory integration coding in barrel cortex LII/III," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    15. Eduardo A Aponte & Dario Schöbi & Klaas E Stephan & Jakob Heinzle, 2017. "The Stochastic Early Reaction, Inhibition, and late Action (SERIA) model for antisaccades," PLOS Computational Biology, Public Library of Science, vol. 13(8), pages 1-36, August.
    16. Jean Daunizeau & Vincent Adam & Lionel Rigoux, 2014. "VBA: A Probabilistic Treatment of Nonlinear Models for Neurobiological and Behavioural Data," PLOS Computational Biology, Public Library of Science, vol. 10(1), pages 1-16, January.
    17. Melody K Morris & Julio Saez-Rodriguez & David C Clarke & Peter K Sorger & Douglas A Lauffenburger, 2011. "Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli," PLOS Computational Biology, Public Library of Science, vol. 7(3), pages 1-20, March.
    18. Alizée Lopez-Persem & Lionel Rigoux & Sacha Bourgeois-Gironde & Jean Daunizeau & Mathias Pessiglione, 2017. "Choose, rate or squeeze: Comparison of economic value functions elicited by different behavioral tasks," PLOS Computational Biology, Public Library of Science, vol. 13(11), pages 1-18, November.
    19. Li Liu & Amit Vira & Emma Friedman & Jennifer Minas & Donald Bolger & Tali Bitan & James Booth, 2010. "Children with Reading Disability Show Brain Differences in Effective Connectivity for Visual, but Not Auditory Word Comprehension," PLOS ONE, Public Library of Science, vol. 5(10), pages 1-11, October.
    20. Richard P Mann & Andrea Perna & Daniel Strömbom & Roman Garnett & James E Herbert-Read & David J T Sumpter & Ashley J W Ward, 2013. "Multi-scale Inference of Interaction Rules in Animal Groups Using Bayesian Model Selection," PLOS Computational Biology, Public Library of Science, vol. 9(3), pages 1-13, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-55064-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.