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Coexistence of state, choice, and sensory integration coding in barrel cortex LII/III

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  • Pierre-Marie Gardères

    (Université Paris Cité, Unit of Neural Circuits Dynamics and Decision Making
    Medical School, RWTH Aachen University)

  • Sébastien Gal

    (Université Paris Cité, Unit of Neural Circuits Dynamics and Decision Making)

  • Charly Rousseau

    (Université Paris Cité, Unit of Neural Circuits Dynamics and Decision Making)

  • Alexandre Mamane

    (Université Paris Cité, Unit of Neural Circuits Dynamics and Decision Making)

  • Dan Alin Ganea

    (Medical School, RWTH Aachen University
    Department of Biomedicine)

  • Florent Haiss

    (Université Paris Cité, Unit of Neural Circuits Dynamics and Decision Making)

Abstract

During perceptually guided decisions, correlates of choice are found as upstream as in the primary sensory areas. However, how well these choice signals align with early sensory representations, a prerequisite for their interpretation as feedforward substrates of perception, remains an open question. We designed a two alternative forced choice task (2AFC) in which male mice compared stimulation frequencies applied to two adjacent vibrissae. The optogenetic silencing of individual columns in the primary somatosensory cortex (wS1) resulted in predicted shifts of psychometric functions, demonstrating that perception depends on focal, early sensory representations. Functional imaging of layer II/III single neurons revealed mixed coding of stimuli, choices and engagement in the task. Neurons with multi-whisker suppression display improved sensory discrimination and had their activity increased during engagement in the task, enhancing selectively representation of the signals relevant to solving the task. From trial to trial, representation of stimuli and choice varied substantially, but mostly orthogonally to each other, suggesting that perceptual variability does not originate from wS1 fluctuations but rather from downstream areas. Together, our results highlight the role of primary sensory areas in forming a reliable sensory substrate that could be used for flexible downstream decision processes.

Suggested Citation

  • Pierre-Marie Gardères & Sébastien Gal & Charly Rousseau & Alexandre Mamane & Dan Alin Ganea & Florent Haiss, 2024. "Coexistence of state, choice, and sensory integration coding in barrel cortex LII/III," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49129-9
    DOI: 10.1038/s41467-024-49129-9
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    References listed on IDEAS

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