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Speed cells in the medial entorhinal cortex

Author

Listed:
  • Emilio Kropff

    (Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology
    Leloir Institute, IIBBA - CONICET)

  • James E. Carmichael

    (Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology
    †Present address: Department of Psychological and Brain Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA.)

  • May-Britt Moser

    (Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology)

  • Edvard I. Moser

    (Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology)

Abstract

Grid cells in the medial entorhinal cortex have spatial firing fields that repeat periodically in a hexagonal pattern. When animals move, activity is translated between grid cells in accordance with the animal’s displacement in the environment. For this translation to occur, grid cells must have continuous access to information about instantaneous running speed. However, a powerful entorhinal speed signal has not been identified. Here we show that running speed is represented in the firing rate of a ubiquitous but functionally dedicated population of entorhinal neurons distinct from other cell populations of the local circuit, such as grid, head-direction and border cells. These ‘speed cells’ are characterized by a context-invariant positive, linear response to running speed, and share with grid cells a prospective bias of ∼50–80 ms. Our observations point to speed cells as a key component of the dynamic representation of self-location in the medial entorhinal cortex.

Suggested Citation

  • Emilio Kropff & James E. Carmichael & May-Britt Moser & Edvard I. Moser, 2015. "Speed cells in the medial entorhinal cortex," Nature, Nature, vol. 523(7561), pages 419-424, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7561:d:10.1038_nature14622
    DOI: 10.1038/nature14622
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    Citations

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    Cited by:

    1. Johnson Ying & Alexandra T. Keinath & Raphael Lavoie & Erika Vigneault & Salah El Mestikawy & Mark P. Brandon, 2022. "Disruption of the grid cell network in a mouse model of early Alzheimer’s disease," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Oliver Barnstedt & Petra Mocellin & Stefan Remy, 2024. "A hippocampus-accumbens code guides goal-directed appetitive behavior," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Diego B. Piza & Benjamin W. Corrigan & Roberto A. Gulli & Sonia Carmo & A. Claudio Cuello & Lyle Muller & Julio Martinez-Trujillo, 2024. "Primacy of vision shapes behavioral strategies and neural substrates of spatial navigation in marmoset hippocampus," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    4. Qiming Shao & Ligu Chen & Xiaowan Li & Miao Li & Hui Cui & Xiaoyue Li & Xinran Zhao & Yuying Shi & Qiang Sun & Kaiyue Yan & Guangfu Wang, 2024. "A non-canonical visual cortical-entorhinal pathway contributes to spatial navigation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    5. Tiziano D’Albis & Richard Kempter, 2017. "A single-cell spiking model for the origin of grid-cell patterns," PLOS Computational Biology, Public Library of Science, vol. 13(10), pages 1-41, October.
    6. Davide Spalla & Alessandro Treves & Charlotte N. Boccara, 2022. "Angular and linear speed cells in the parahippocampal circuits," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    7. Lin Yang & Mengdi Zhang & Yuan Zhou & Dongxiao Jiang & Lilong Yu & Lingyu Xu & Fan Fei & Wenkai Lin & Yanrong Zheng & Jiannong Wu & Yi Wang & Zhong Chen, 2024. "Histamine-tuned subicular circuit mediates alert-driven accelerated locomotion in mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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