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Large-scale metagenomic analysis of oral microbiomes reveals markers for autism spectrum disorders

Author

Listed:
  • Paolo Manghi

    (University of Trento
    via Mach 1)

  • Michele Filosi

    (University of Trento
    EURAC Research Institute for Biomedicine BIO)

  • Moreno Zolfo

    (University of Trento
    Okinawa Institute of Science and Technology (OIST))

  • Lucas G. Casten

    (University of Iowa)

  • Albert Garcia-Valiente

    (University of Trento)

  • Stefania Mattevi

    (University of Trento
    University of Brescia)

  • Vitor Heidrich

    (University of Trento)

  • Davide Golzato

    (University of Trento)

  • Samuel Perini

    (University of Trento)

  • Andrew M. Thomas

    (University of Trento)

  • Simone Montalbano

    (University of Trento
    Copenhagen University Hospital)

  • Samuele Cancellieri

    (University of Trento
    University of Oslo)

  • Levi Waldron

    (Institute for Implementation Science in Public Health)

  • Jacob B. Hall

    (Simons Foundation)

  • Simon Xu

    (Simons Foundation)

  • Natalia Volfovsky

    (Simons Foundation)

  • LeeAnne Green Snyder

    (Simons Foundation
    Boston Children’s Hospital)

  • Pamela Feliciano

    (Simons Foundation
    Boston Children’s Hospital)

  • Francesco Asnicar

    (University of Trento)

  • Mireia Valles-Colomer

    (University Pompeu Fabra)

  • Jacob J. Michaelson

    (University of Iowa)

  • Nicola Segata

    (University of Trento
    European Institute of Oncology IRCCS)

  • Enrico Domenici

    (University of Trento)

Abstract

The link between the oral microbiome and neurodevelopmental disorders remains a compelling hypothesis, still requiring confirmation in large-scale datasets. Leveraging over 7000 whole-genome sequenced salivary samples from 2025 US families with children diagnosed with autism spectrum disorders (ASD), our cross-sectional study shows that the oral microbiome composition can discriminate ASD subjects from neurotypical siblings (NTs, AUC = 0.66), with 108 differentiating species (q

Suggested Citation

  • Paolo Manghi & Michele Filosi & Moreno Zolfo & Lucas G. Casten & Albert Garcia-Valiente & Stefania Mattevi & Vitor Heidrich & Davide Golzato & Samuel Perini & Andrew M. Thomas & Simone Montalbano & Sa, 2024. "Large-scale metagenomic analysis of oral microbiomes reveals markers for autism spectrum disorders," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53934-7
    DOI: 10.1038/s41467-024-53934-7
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    References listed on IDEAS

    as
    1. Mireia Valles-Colomer & Aitor Blanco-Míguez & Paolo Manghi & Francesco Asnicar & Leonard Dubois & Davide Golzato & Federica Armanini & Fabio Cumbo & Kun D. Huang & Serena Manara & Giulia Masetti & Fed, 2023. "The person-to-person transmission landscape of the gut and oral microbiomes," Nature, Nature, vol. 614(7946), pages 125-135, February.
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