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Mobile genes in the human microbiome are structured from global to individual scales

Author

Listed:
  • I. L. Brito

    (Massachusetts Institute of Technology
    Broad Institute of MIT and Harvard)

  • S. Yilmaz

    (Sandia National Laboratories)

  • K. Huang

    (Broad Institute of MIT and Harvard)

  • L. Xu

    (Broad Institute of MIT and Harvard)

  • S. D. Jupiter

    (Wildlife Conservation Society)

  • A. P. Jenkins

    (Edith Cowan University)

  • W. Naisilisili

    (Wildlife Conservation Society)

  • M. Tamminen

    (Department of Aquatic Ecology
    Department of Environmental Systems Science)

  • C. S. Smillie

    (Massachusetts Institute of Technology)

  • J. R. Wortman

    (Broad Institute of MIT and Harvard)

  • B. W. Birren

    (Broad Institute of MIT and Harvard)

  • R. J. Xavier

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital
    Center for Microbiome, Informatics and Therapeutics, Massachusetts Institute of Technology)

  • P. C. Blainey

    (Broad Institute of MIT and Harvard)

  • A. K. Singh

    (Sandia National Laboratories)

  • D. Gevers

    (Broad Institute of MIT and Harvard)

  • E. J. Alm

    (Massachusetts Institute of Technology
    Broad Institute of MIT and Harvard
    Center for Microbiome, Informatics and Therapeutics, Massachusetts Institute of Technology)

Abstract

Mobile genes, which can be transferred between bacterial species in the microbiome to impart properties such as antibiotic resistance, are reflective of human activity and local diets.

Suggested Citation

  • I. L. Brito & S. Yilmaz & K. Huang & L. Xu & S. D. Jupiter & A. P. Jenkins & W. Naisilisili & M. Tamminen & C. S. Smillie & J. R. Wortman & B. W. Birren & R. J. Xavier & P. C. Blainey & A. K. Singh & , 2016. "Mobile genes in the human microbiome are structured from global to individual scales," Nature, Nature, vol. 535(7612), pages 435-439, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7612:d:10.1038_nature18927
    DOI: 10.1038/nature18927
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    Cited by:

    1. Zhenyan Zhang & Qi Zhang & Tingzhang Wang & Nuohan Xu & Tao Lu & Wenjie Hong & Josep Penuelas & Michael Gillings & Meixia Wang & Wenwen Gao & Haifeng Qian, 2022. "Assessment of global health risk of antibiotic resistance genes," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Paolo Manghi & Michele Filosi & Moreno Zolfo & Lucas G. Casten & Albert Garcia-Valiente & Stefania Mattevi & Vitor Heidrich & Davide Golzato & Samuel Perini & Andrew M. Thomas & Simone Montalbano & Sa, 2024. "Large-scale metagenomic analysis of oral microbiomes reveals markers for autism spectrum disorders," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Shiben Zhu & Juken Hong & Teng Wang, 2024. "Horizontal gene transfer is predicted to overcome the diversity limit of competing microbial species," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    4. Kihyun Lee & Sebastien Raguideau & Kimmo Sirén & Francesco Asnicar & Fabio Cumbo & Falk Hildebrand & Nicola Segata & Chang-Jun Cha & Christopher Quince, 2023. "Population-level impacts of antibiotic usage on the human gut microbiome," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    5. Aarthi Ravikrishnan & Indrik Wijaya & Eileen Png & Kern Rei Chng & Eliza Xin Pei Ho & Amanda Hui Qi Ng & Ahmad Nazri Mohamed Naim & Jean-Sebastien Gounot & Shou Ping Guan & Jasinda Lee Hanqing & Lihua, 2024. "Gut metagenomes of Asian octogenarians reveal metabolic potential expansion and distinct microbial species associated with aging phenotypes," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    6. Peter J. Diebold & Matthew W. Rhee & Qiaojuan Shi & Nguyen Vinh Trung & Fayaz Umrani & Sheraz Ahmed & Vandana Kulkarni & Prasad Deshpande & Mallika Alexander & Ngo Hoa & Nicholas A. Christakis & Najee, 2023. "Clinically relevant antibiotic resistance genes are linked to a limited set of taxa within gut microbiome worldwide," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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