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Microbial tryptophan catabolites in health and disease

Author

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  • Henrik M. Roager

    (University of Copenhagen
    Technical University of Denmark)

  • Tine R. Licht

    (Technical University of Denmark)

Abstract

Accumulating evidence implicates metabolites produced by gut microbes as crucial mediators of diet-induced host-microbial cross-talk. Here, we review emerging data suggesting that microbial tryptophan catabolites resulting from proteolysis are influencing host health. These metabolites are suggested to activate the immune system through binding to the aryl hydrocarbon receptor (AHR), enhance the intestinal epithelial barrier, stimulate gastrointestinal motility, as well as secretion of gut hormones, exert anti-inflammatory, anti-oxidative or toxic effects in systemic circulation, and putatively modulate gut microbial composition. Tryptophan catabolites thus affect various physiological processes and may contribute to intestinal and systemic homeostasis in health and disease.

Suggested Citation

  • Henrik M. Roager & Tine R. Licht, 2018. "Microbial tryptophan catabolites in health and disease," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05470-4
    DOI: 10.1038/s41467-018-05470-4
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    Cited by:

    1. Giorgia Renga & Fiorella D’Onofrio & Marilena Pariano & Roberta Galarini & Carolina Barola & Claudia Stincardini & Marina M. Bellet & Helmut Ellemunter & Cornelia Lass-Flörl & Claudio Costantini & Val, 2023. "Bridging of host-microbiota tryptophan partitioning by the serotonin pathway in fungal pneumonia," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Marta G. Novelle, 2021. "Decoding the Role of Gut-Microbiome in the Food Addiction Paradigm," IJERPH, MDPI, vol. 18(13), pages 1-19, June.
    3. Kirsty Brown & Carolyn A. Thomson & Soren Wacker & Marija Drikic & Ryan Groves & Vina Fan & Ian A. Lewis & Kathy D. McCoy, 2023. "Microbiota alters the metabolome in an age- and sex- dependent manner in mice," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Mouna Chajadine & Ludivine Laurans & Tobias Radecke & Nirmala Mouttoulingam & Rida Al-Rifai & Emilie Bacquer & Clara Delaroque & Héloïse Rytter & Marius Bredon & Camille Knosp & José Vilar & Coralie F, 2024. "Harnessing intestinal tryptophan catabolism to relieve atherosclerosis in mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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