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Early postnatal serotonin modulation prevents adult-stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming

Author

Listed:
  • Hyosang Kim

    (Korea Advanced Institute for Science and Technology (KAIST))

  • Doyoun Kim

    (Institute for Basic Science (IBS))

  • Yisul Cho

    (Kyungpook National University)

  • Kyungdeok Kim

    (Institute for Basic Science (IBS))

  • Junyeop Daniel Roh

    (Institute for Basic Science (IBS))

  • Yangsik Kim

    (Korea Advanced Institute for Science and Technology (KAIST))

  • Esther Yang

    (Korea University)

  • Seong Soon Kim

    (Korea Research Institute of Chemical Technology (KRICT))

  • Sunjoo Ahn

    (Korea Research Institute of Chemical Technology (KRICT))

  • Hyun Kim

    (Korea University)

  • Hyojin Kang

    (Korea Institute of Science and Technology Information)

  • Yongchul Bae

    (Kyungpook National University)

  • Eunjoon Kim

    (Korea Advanced Institute for Science and Technology (KAIST)
    Institute for Basic Science (IBS))

Abstract

Autism spectrum disorder is characterized by early postnatal symptoms, although little is known about the mechanistic deviations that produce them and whether correcting them has long-lasting preventive effects on adult-stage deficits. ARID1B, a chromatin remodeler implicated in neurodevelopmental disorders, including autism spectrum disorder, exhibits strong embryonic- and early postnatal-stage expression. We report here that Arid1b-happloinsufficient (Arid1b+/–) mice display autistic-like behaviors at juvenile and adult stages accompanied by persistent decreases in excitatory synaptic density and transmission. Chronic treatment of Arid1b+/– mice with fluoxetine, a selective serotonin-reuptake inhibitor, during the first three postnatal weeks prevents synaptic and behavioral deficits in adults. Mechanistically, these rescues accompany transcriptomic changes, including upregulation of FMRP targets and normalization of HDAC4/MEF2A-related transcriptional regulation of the synaptic proteins, SynGAP1 and Arc. These results suggest that chronic modulation of serotonergic receptors during critical early postnatal periods prevents synaptic and behavioral deficits in adult Arid1b+/– mice through transcriptional reprogramming.

Suggested Citation

  • Hyosang Kim & Doyoun Kim & Yisul Cho & Kyungdeok Kim & Junyeop Daniel Roh & Yangsik Kim & Esther Yang & Seong Soon Kim & Sunjoo Ahn & Hyun Kim & Hyojin Kang & Yongchul Bae & Eunjoon Kim, 2022. "Early postnatal serotonin modulation prevents adult-stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32748-5
    DOI: 10.1038/s41467-022-32748-5
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