IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-53059-x.html
   My bibliography  Save this article

Multi-scenario surveillance of respiratory viruses in aerosols with sub-single-copy spatial resolution

Author

Listed:
  • Bao Li

    (Tsinghua University
    Changping Laboratory)

  • Baobao Lin

    (Tsinghua University)

  • Yan Wang

    (Peking University First Hospital)

  • Ye Shi

    (Wenzhou Medical University)

  • Wu Zeng

    (Tsinghua University
    Changping Laboratory)

  • Yulan Zhao

    (Changping Laboratory)

  • Yin Gu

    (China Astronaut Research and Training Center)

  • Chang Liu

    (Tsinghua University)

  • Hui Gao

    (Peking University First Hospital)

  • Hao Cheng

    (Peking University First Hospital)

  • Xiaoqun Zheng

    (Wenzhou Medical University)

  • Guangxin Xiang

    (Wenzhou Medical University)

  • Guiqiang Wang

    (Peking University First Hospital
    Peking University International Hospital
    Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases)

  • Peng Liu

    (Tsinghua University
    Changping Laboratory)

Abstract

Highly sensitive airborne virus monitoring is critical for preventing and containing epidemics. However, the detection of airborne viruses at ultra-low concentrations remains challenging due to the lack of ultra-sensitive methods and easy-to-deployment equipment. Here, we present an integrated microfluidic cartridge that can accurately detect SARS-COV-2, Influenza A, B, and respiratory syncytial virus with a sensitivity of 10 copies/mL. When integrated with a high-flow aerosol sampler, our microdevice can achieve a sub-single-copy spatial resolution of 0.83 copies/m3 for airborne virus surveillance with an air flow rate of 400 L/min and a sampling time of 30 minutes. We then designed a series of virus-in-aerosols monitoring systems (RIAMs), including versions of a multi-site sampling RIAMs (M-RIAMs), a stationary real-time RIAMs (S-RIAMs), and a roaming real-time RIAMs (R-RIAMs) for different application scenarios. Using M-RIAMs, we performed a comprehensive evaluation of 210 environmental samples from COVID-19 patient wards, including 30 aerosol samples. The highest positive detection rate of aerosol samples (60%) proved the aerosol-based SARS-CoV-2 monitoring represents an effective method for spatial risk assessment. The detection of 78 aerosol samples in real-world settings via S-RIAMs confirmed its reliability for ultra-sensitive and continuous airborne virus monitoring. Therefore, RIAMs shows the potential as an effective solution for mitigating the risk of airborne virus transmission.

Suggested Citation

  • Bao Li & Baobao Lin & Yan Wang & Ye Shi & Wu Zeng & Yulan Zhao & Yin Gu & Chang Liu & Hui Gao & Hao Cheng & Xiaoqun Zheng & Guangxin Xiang & Guiqiang Wang & Peng Liu, 2024. "Multi-scenario surveillance of respiratory viruses in aerosols with sub-single-copy spatial resolution," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53059-x
    DOI: 10.1038/s41467-024-53059-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-53059-x
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-024-53059-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Mitchell D. Ramuta & Christina M. Newman & Savannah F. Brakefield & Miranda R. Stauss & Roger W. Wiseman & Amanda Kita-Yarbro & Eli J. O’Connor & Neeti Dahal & Ailam Lim & Keith P. Poulsen & Nasia Saf, 2022. "SARS-CoV-2 and other respiratory pathogens are detected in continuous air samples from congregate settings," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Leonardo Setti & Fabrizio Passarini & Gianluigi De Gennaro & Pierluigi Barbieri & Maria Grazia Perrone & Massimo Borelli & Jolanda Palmisani & Alessia Di Gilio & Prisco Piscitelli & Alessandro Miani, 2020. "Airborne Transmission Route of COVID-19: Why 2 Meters/6 Feet of Inter-Personal Distance Could Not Be Enough," IJERPH, MDPI, vol. 17(8), pages 1-6, April.
    3. Yuan Liu & Zhi Ning & Yu Chen & Ming Guo & Yingle Liu & Nirmal Kumar Gali & Li Sun & Yusen Duan & Jing Cai & Dane Westerdahl & Xinjin Liu & Ke Xu & Kin-fai Ho & Haidong Kan & Qingyan Fu & Ke Lan, 2020. "Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals," Nature, Nature, vol. 582(7813), pages 557-560, June.
    4. Joseph V. Puthussery & Dishit P. Ghumra & Kevin R. McBrearty & Brookelyn M. Doherty & Benjamin J. Sumlin & Amirhossein Sarabandi & Anushka Garg Mandal & Nishit J. Shetty & Woodrow D. Gardiner & Jordan, 2023. "Real-time environmental surveillance of SARS-CoV-2 aerosols," Nature Communications, Nature, vol. 14(1), pages 1-7, December.
    5. Joren Raymenants & Caspar Geenen & Lore Budts & Jonathan Thibaut & Marijn Thijssen & Hannelore Mulder & Sarah Gorissen & Bastiaan Craessaerts & Lies Laenen & Kurt Beuselinck & Sien Ombelet & Els Keyae, 2023. "Indoor air surveillance and factors associated with respiratory pathogen detection in community settings in Belgium," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    6. Solomon Hsiang & Daniel Allen & Sébastien Annan-Phan & Kendon Bell & Ian Bolliger & Trinetta Chong & Hannah Druckenmiller & Luna Yue Huang & Andrew Hultgren & Emma Krasovich & Peiley Lau & Jaecheol Le, 2020. "The effect of large-scale anti-contagion policies on the COVID-19 pandemic," Nature, Nature, vol. 584(7820), pages 262-267, August.
    7. Po Ying Chia & Kristen Kelli Coleman & Yian Kim Tan & Sean Wei Xiang Ong & Marcus Gum & Sok Kiang Lau & Xiao Fang Lim & Ai Sim Lim & Stephanie Sutjipto & Pei Hua Lee & Than The Son & Barnaby Edward Yo, 2020. "Detection of air and surface contamination by SARS-CoV-2 in hospital rooms of infected patients," Nature Communications, Nature, vol. 11(1), pages 1-7, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Wright, Austin L. & Sonin, Konstantin & Driscoll, Jesse & Wilson, Jarnickae, 2020. "Poverty and economic dislocation reduce compliance with COVID-19 shelter-in-place protocols," Journal of Economic Behavior & Organization, Elsevier, vol. 180(C), pages 544-554.
    2. Marco Colagrossi & Claudio Deiana & Andrea Geraci & Ludovica Giua, 2022. "Hang up on stereotypes: Domestic violence and an anti‐abuse helpline campaign," Contemporary Economic Policy, Western Economic Association International, vol. 40(4), pages 585-611, October.
    3. Xiao Chen & Hanwei Huang & Jiandong Ju & Ruoyan Sun & Jialiang Zhang, 2022. "Endogenous cross-region human mobility and pandemics," CEP Discussion Papers dp1860, Centre for Economic Performance, LSE.
    4. Wang, Peipei & Liu, Haiyan & Zheng, Xinqi & Ma, Ruifang, 2023. "A new method for spatio-temporal transmission prediction of COVID-19," Chaos, Solitons & Fractals, Elsevier, vol. 167(C).
    5. Pelagatti, Matteo & Maranzano, Paolo, 2021. "Assessing the effectiveness of the Italian risk-zones policy during the second wave of COVID-19," Health Policy, Elsevier, vol. 125(9), pages 1188-1199.
    6. Davide Furceri & Siddharth Kothari & Longmei Zhang, 2021. "The effects of COVID‐19 containment measures on the Asia‐Pacific region," Pacific Economic Review, Wiley Blackwell, vol. 26(4), pages 469-497, October.
    7. Larisa Anghel & Cătălin-George Popovici & Cristian Stătescu & Radu Sascău & Marina Verdeș & Vasilică Ciocan & Ionela-Lăcrămioara Șerban & Minela Aida Mărănducă & Sebastian-Valeriu Hudișteanu & Florin-, 2020. "Impact of HVAC-Systems on the Dispersion of Infectious Aerosols in a Cardiac Intensive Care Unit," IJERPH, MDPI, vol. 17(18), pages 1-17, September.
    8. Jesper Akesson & Sam Ashworth-Hayes & Robert Hahn & Robert Metcalfe & Itzhak Rasooly, 2022. "Fatalism, beliefs, and behaviors during the COVID-19 pandemic," Journal of Risk and Uncertainty, Springer, vol. 64(2), pages 147-190, April.
    9. Andrew G. Atkeson & Karen A. Kopecky & Tao Zha, 2024. "Four Stylized Facts About Covid‐19," International Economic Review, Department of Economics, University of Pennsylvania and Osaka University Institute of Social and Economic Research Association, vol. 65(1), pages 3-42, February.
    10. Maxim Ananyev & Michael Poyker & Yuan Tian, 2021. "The safest time to fly: pandemic response in the era of Fox News," Journal of Population Economics, Springer;European Society for Population Economics, vol. 34(3), pages 775-802, July.
    11. Matthew Spiegel & Heather Tookes, 2021. "Business Restrictions and COVID-19 Fatalities [The immediate effect of COVID-19 policies on social distancing behavior in the United States]," The Review of Financial Studies, Society for Financial Studies, vol. 34(11), pages 5266-5308.
    12. Borsati, Mattia & Nocera, Silvio & Percoco, Marco, 2022. "Questioning the spatial association between the initial spread of COVID-19 and transit usage in Italy," Research in Transportation Economics, Elsevier, vol. 95(C).
    13. Yang Han & Jacqueline C. K. Lam & Victor O. K. Li & Jon Crowcroft, 2024. "Interpretable AI-driven causal inference to uncover the time-varying effects of PM2.5 and public health interventions on COVID-19 infection rates," Palgrave Communications, Palgrave Macmillan, vol. 11(1), pages 1-17, December.
    14. Alvaro Garcia-Sanchez & Juan-Francisco Peña-Cardelles & Esther Ordonez-Fernandez & María Montero-Alonso & Naresh Kewalramani & Angel-Orión Salgado-Peralvo & Dániel Végh & Angélica Gargano & Gabriela P, 2022. "Povidone-Iodine as a Pre-Procedural Mouthwash to Reduce the Salivary Viral Load of SARS-CoV-2: A Systematic Review of Randomized Controlled Trials," IJERPH, MDPI, vol. 19(5), pages 1-9, March.
    15. Dhaval Dave & Drew McNichols & Joseph J. Sabia, 2022. "Political violence, risk aversion, and population health: Evidence from the US Capitol riot," Journal of Population Economics, Springer;European Society for Population Economics, vol. 35(4), pages 1345-1384, October.
    16. Marta Baselga & Juan J. Alba & Alberto J. Schuhmacher, 2022. "The Control of Metabolic CO 2 in Public Transport as a Strategy to Reduce the Transmission of Respiratory Infectious Diseases," IJERPH, MDPI, vol. 19(11), pages 1-19, May.
    17. Huang, Yubo & Wu, Yan & Zhang, Weidong, 2020. "Comprehensive identification and isolation policies have effectively suppressed the spread of COVID-19," Chaos, Solitons & Fractals, Elsevier, vol. 139(C).
    18. Daniele Proverbio & Françoise Kemp & Stefano Magni & Jorge Gonçalves, 2022. "Performance of early warning signals for disease re-emergence: A case study on COVID-19 data," PLOS Computational Biology, Public Library of Science, vol. 18(3), pages 1-22, March.
    19. Edoardo Di Porto & Paolo Naticchioni & Vincenzo Scrutinio, 2020. "Partial Lockdown and the Spread of Covid-19: Lessons from the Italian Case," CSEF Working Papers 569, Centre for Studies in Economics and Finance (CSEF), University of Naples, Italy.
    20. Ho Fai Chan & Martin Brumpton & Alison Macintyre & Jefferson Arapoc & David A Savage & Ahmed Skali & David Stadelmann & Benno Torgler, 2020. "How confidence in health care systems affects mobility and compliance during the COVID-19 pandemic," PLOS ONE, Public Library of Science, vol. 15(10), pages 1-18, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53059-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.