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Povidone-Iodine as a Pre-Procedural Mouthwash to Reduce the Salivary Viral Load of SARS-CoV-2: A Systematic Review of Randomized Controlled Trials

Author

Listed:
  • Alvaro Garcia-Sanchez

    (Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT 06030, USA)

  • Juan-Francisco Peña-Cardelles

    (Department of Health Sciences, Rey Juan Carlos University, 28040 Madrid, Spain
    Oral and Maxillofacial Surgery Department, School of Dental Medicine, University of Connecticut Health, Farmington, CT 06030, USA
    Department of Prosthodontics, School of Dental Medicine, University of Connecticut Health, Farmington, CT 06030, USA)

  • Esther Ordonez-Fernandez

    (Division of General Dentistry, Department of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT 06030, USA)

  • María Montero-Alonso

    (Pediatric Service, Hospital Álvaro Cunqueiro, 36213 Vigo, Spain)

  • Naresh Kewalramani

    (Department of Nursery and Stomatology, Rey Juan Carlos University, 28922 Madrid, Spain)

  • Angel-Orión Salgado-Peralvo

    (Department of Stomatology, Faculty of Dentistry, University of Seville, 41009 Seville, Spain)

  • Dániel Végh

    (Department of Prosthodontics, Semmelweis University, 1085 Budapest, Hungary
    Division of Oral Surgery and Orthodontics, Department of Dentistry and Oral Health, Medical University of Graz, 8010 Graz, Austria)

  • Angélica Gargano

    (Division of General Dentistry, Department of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT 06030, USA)

  • Gabriela Parra

    (Division of General Dentistry, Department of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT 06030, USA)

  • Lourdes-Isabela Guerra-Guajardo

    (Division of General Dentistry, Department of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT 06030, USA)

  • Wataru Kozuma

    (Department of Prosthodontics, School of Dental Medicine, University of Connecticut Health, Farmington, CT 06030, USA
    Department of Regenerative and Reconstructive Dental Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan)

Abstract

The use of pre-procedural rinses has been investigated to reduce the number of viral particles and bacteria in aerosols, potentially decreasing the risk of cross-infection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during medical and dental procedures. This review aims to confirm whether there is evidence in the literature describing a reduction in salivary load of SARS-CoV-2 when povidone-iodine (PVP-I) is used as a pre-intervention mouthwash. An search of the MEDLINE, Embase, SCOPUS, and the Cochrane library databases was conducted. The criteria used followed the PRISMA ® Statement guidelines. Randomized controlled trials investigating the reduction of salivary load of SARS-CoV-2 using PVP-I were included. Ultimately, four articles were included that met the established criteria. According to the current evidence, PVP-I is effective against SARS-CoV-2 in saliva and could be implemented as a rinse before interventions to decrease the risk of cross-infection in healthcare settings.

Suggested Citation

  • Alvaro Garcia-Sanchez & Juan-Francisco Peña-Cardelles & Esther Ordonez-Fernandez & María Montero-Alonso & Naresh Kewalramani & Angel-Orión Salgado-Peralvo & Dániel Végh & Angélica Gargano & Gabriela P, 2022. "Povidone-Iodine as a Pre-Procedural Mouthwash to Reduce the Salivary Viral Load of SARS-CoV-2: A Systematic Review of Randomized Controlled Trials," IJERPH, MDPI, vol. 19(5), pages 1-9, March.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:5:p:2877-:d:762018
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    References listed on IDEAS

    as
    1. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    2. Yuan Liu & Zhi Ning & Yu Chen & Ming Guo & Yingle Liu & Nirmal Kumar Gali & Li Sun & Yusen Duan & Jing Cai & Dane Westerdahl & Xinjin Liu & Ke Xu & Kin-fai Ho & Haidong Kan & Qingyan Fu & Ke Lan, 2020. "Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals," Nature, Nature, vol. 582(7813), pages 557-560, June.
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    Cited by:

    1. Shoji Takenaka & Maki Sotozono & Asaka Yashiro & Rui Saito & Niraya Kornsombut & Traithawit Naksagoon & Ryoko Nagata & Takako Ida & Naoki Edanami & Yuichiro Noiri, 2022. "Efficacy of Combining an Extraoral High-Volume Evacuator with Preprocedural Mouth Rinsing in Reducing Aerosol Contamination Produced by Ultrasonic Scaling," IJERPH, MDPI, vol. 19(10), pages 1-10, May.

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