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Endogenous cannabinoids in the piriform cortex tune olfactory perception

Author

Listed:
  • Geoffrey Terral

    (Univ. Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297
    Univ. Bordeaux, INSERM, Neurocentre Magendie, U1215)

  • Evan Harrell

    (Univ. Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297)

  • Gabriel Lepousez

    (Perception and Memory Unit, CNRS, Joint Research Unit 3571, Université Paris Cité, Institut Pasteur)

  • Yohan Wards

    (Univ. Bordeaux, INSERM, Neurocentre Magendie, U1215)

  • Dinghuang Huang

    (Univ. Bordeaux, INSERM, Neurocentre Magendie, U1215)

  • Tiphaine Dolique

    (Inovarion)

  • Giulio Casali

    (Univ. Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297)

  • Antoine Nissant

    (Perception and Memory Unit, CNRS, Joint Research Unit 3571, Université Paris Cité, Institut Pasteur)

  • Pierre-Marie Lledo

    (Perception and Memory Unit, CNRS, Joint Research Unit 3571, Université Paris Cité, Institut Pasteur)

  • Guillaume Ferreira

    (Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeurO, UMR 1286)

  • Giovanni Marsicano

    (Univ. Bordeaux, INSERM, Neurocentre Magendie, U1215)

  • Lisa Roux

    (Univ. Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297)

Abstract

Sensory perception depends on interactions between external inputs transduced by peripheral sensory organs and internal network dynamics generated by central neuronal circuits. In the sensory cortex, desynchronized network states associate with high signal-to-noise ratio stimulus-evoked responses and heightened perception. Cannabinoid-type-1-receptors (CB1Rs) - which influence network coordination in the hippocampus - are present in anterior piriform cortex (aPC), a sensory paleocortex supporting olfactory perception. Yet, how CB1Rs shape aPC network activity and affect odor perception is unknown. Using pharmacological manipulations coupled with multi-electrode recordings or fiber photometry in the aPC of freely moving male mice, we show that systemic CB1R blockade as well as local drug infusion increases the amplitude of gamma oscillations in aPC, while simultaneously reducing the occurrence of synchronized population events involving aPC excitatory neurons. In animals exposed to odor sources, blockade of CB1Rs reduces correlation among aPC excitatory units and lowers behavioral olfactory detection thresholds. These results suggest that endogenous endocannabinoid signaling promotes synchronized population events and dampen gamma oscillations in the aPC which results in a reduced sensitivity to external sensory inputs.

Suggested Citation

  • Geoffrey Terral & Evan Harrell & Gabriel Lepousez & Yohan Wards & Dinghuang Huang & Tiphaine Dolique & Giulio Casali & Antoine Nissant & Pierre-Marie Lledo & Guillaume Ferreira & Giovanni Marsicano & , 2024. "Endogenous cannabinoids in the piriform cortex tune olfactory perception," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45161-x
    DOI: 10.1038/s41467-024-45161-x
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    References listed on IDEAS

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    1. Paula Gómez-Sotres & Urszula Skupio & Tommaso Dalla Tor & Francisca Julio-Kalajzic & Astrid Cannich & Doriane Gisquet & Itziar Bonilla-Del Rio & Filippo Drago & Nagore Puente & Pedro Grandes & Luigi B, 2024. "Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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