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Designed 2D protein crystals as dynamic molecular gatekeepers for a solid-state device

Author

Listed:
  • Sanahan Vijayakumar

    (University of California, San Diego)

  • Robert G. Alberstein

    (University of California, San Diego)

  • Zhiyin Zhang

    (University of California, San Diego)

  • Yi-Sheng Lu

    (University of California, San Diego)

  • Adriano Chan

    (University of California, San Diego)

  • Charlotte E. Wahl

    (4161 Campus Point Ct)

  • James S. Ha

    (4161 Campus Point Ct
    505 King Ave Columbus)

  • Deborah E. Hunka

    (4161 Campus Point Ct)

  • Gerry R. Boss

    (University of California, San Diego)

  • Michael J. Sailor

    (University of California, San Diego
    University of California, San Diego
    University of California, San Diego)

  • F. Akif Tezcan

    (University of California, San Diego
    University of California, San Diego)

Abstract

The sensitivity and responsiveness of living cells to environmental changes are enabled by dynamic protein structures, inspiring efforts to construct artificial supramolecular protein assemblies. However, despite their sophisticated structures, designed protein assemblies have yet to be incorporated into macroscale devices for real-life applications. We report a 2D crystalline protein assembly of C98/E57/E66L-rhamnulose-1-phosphate aldolase (CEERhuA) that selectively blocks or passes molecular species when exposed to a chemical trigger. CEERhuA crystals are engineered via cobalt(II) coordination bonds to undergo a coherent conformational change from a closed state (pore dimensions

Suggested Citation

  • Sanahan Vijayakumar & Robert G. Alberstein & Zhiyin Zhang & Yi-Sheng Lu & Adriano Chan & Charlotte E. Wahl & James S. Ha & Deborah E. Hunka & Gerry R. Boss & Michael J. Sailor & F. Akif Tezcan, 2024. "Designed 2D protein crystals as dynamic molecular gatekeepers for a solid-state device," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50567-8
    DOI: 10.1038/s41467-024-50567-8
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    References listed on IDEAS

    as
    1. Eyal Golub & Rohit H. Subramanian & Julian Esselborn & Robert G. Alberstein & Jake B. Bailey & Jerika A. Chiong & Xiaodong Yan & Timothy Booth & Timothy S. Baker & F. Akif Tezcan, 2020. "Constructing protein polyhedra via orthogonal chemical interactions," Nature, Nature, vol. 578(7793), pages 172-176, February.
    2. Ariel J. Ben-Sasson & Joseph L. Watson & William Sheffler & Matthew Camp Johnson & Alice Bittleston & Logeshwaran Somasundaram & Justin Decarreau & Fang Jiao & Jiajun Chen & Ioanna Mela & Andrew A. Dr, 2021. "Author Correction: Design of biologically active binary protein 2D materials," Nature, Nature, vol. 591(7850), pages 16-16, March.
    3. Shuai Zhang & Robert G. Alberstein & James J. Yoreo & F. Akif Tezcan, 2020. "Assembly of a patchy protein into variable 2D lattices via tunable multiscale interactions," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    4. J. M. Kefauver & A. B. Ward & A. Patapoutian, 2020. "Discoveries in structure and physiology of mechanically activated ion channels," Nature, Nature, vol. 587(7835), pages 567-576, November.
    5. Yuta Suzuki & Giovanni Cardone & David Restrepo & Pablo D. Zavattieri & Timothy S. Baker & F. Akif Tezcan, 2016. "Self-assembly of coherently dynamic, auxetic, two-dimensional protein crystals," Nature, Nature, vol. 533(7603), pages 369-373, May.
    6. Ariel J. Ben-Sasson & Joseph L. Watson & William Sheffler & Matthew Camp Johnson & Alice Bittleston & Logeshwaran Somasundaram & Justin Decarreau & Fang Jiao & Jiajun Chen & Ioanna Mela & Andrew A. Dr, 2021. "Design of biologically active binary protein 2D materials," Nature, Nature, vol. 589(7842), pages 468-473, January.
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