IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-50567-8.html
   My bibliography  Save this article

Designed 2D protein crystals as dynamic molecular gatekeepers for a solid-state device

Author

Listed:
  • Sanahan Vijayakumar

    (University of California, San Diego)

  • Robert G. Alberstein

    (University of California, San Diego)

  • Zhiyin Zhang

    (University of California, San Diego)

  • Yi-Sheng Lu

    (University of California, San Diego)

  • Adriano Chan

    (University of California, San Diego)

  • Charlotte E. Wahl

    (4161 Campus Point Ct)

  • James S. Ha

    (4161 Campus Point Ct
    505 King Ave Columbus)

  • Deborah E. Hunka

    (4161 Campus Point Ct)

  • Gerry R. Boss

    (University of California, San Diego)

  • Michael J. Sailor

    (University of California, San Diego
    University of California, San Diego
    University of California, San Diego)

  • F. Akif Tezcan

    (University of California, San Diego
    University of California, San Diego)

Abstract

The sensitivity and responsiveness of living cells to environmental changes are enabled by dynamic protein structures, inspiring efforts to construct artificial supramolecular protein assemblies. However, despite their sophisticated structures, designed protein assemblies have yet to be incorporated into macroscale devices for real-life applications. We report a 2D crystalline protein assembly of C98/E57/E66L-rhamnulose-1-phosphate aldolase (CEERhuA) that selectively blocks or passes molecular species when exposed to a chemical trigger. CEERhuA crystals are engineered via cobalt(II) coordination bonds to undergo a coherent conformational change from a closed state (pore dimensions

Suggested Citation

  • Sanahan Vijayakumar & Robert G. Alberstein & Zhiyin Zhang & Yi-Sheng Lu & Adriano Chan & Charlotte E. Wahl & James S. Ha & Deborah E. Hunka & Gerry R. Boss & Michael J. Sailor & F. Akif Tezcan, 2024. "Designed 2D protein crystals as dynamic molecular gatekeepers for a solid-state device," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50567-8
    DOI: 10.1038/s41467-024-50567-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-50567-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-50567-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50567-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.