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Assembly of a patchy protein into variable 2D lattices via tunable multiscale interactions

Author

Listed:
  • Shuai Zhang

    (University of Washington
    Physical Sciences Division, Pacific Northwest National Laboratory)

  • Robert G. Alberstein

    (University of California, San Diego)

  • James J. Yoreo

    (University of Washington
    Physical Sciences Division, Pacific Northwest National Laboratory)

  • F. Akif Tezcan

    (University of California, San Diego
    University of California, San Diego)

Abstract

Self-assembly of molecular building blocks into higher-order structures is exploited in living systems to create functional complexity and represents a powerful strategy for constructing new materials. As nanoscale building blocks, proteins offer unique advantages, including monodispersity and atomically tunable interactions. Yet, control of protein self-assembly has been limited compared to inorganic or polymeric nanoparticles, which lack such attributes. Here, we report modular self-assembly of an engineered protein into four physicochemically distinct, precisely patterned 2D crystals via control of four classes of interactions spanning Ångström to several-nanometer length scales. We relate the resulting structures to the underlying free-energy landscape by combining in-situ atomic force microscopy observations of assembly with thermodynamic analyses of protein-protein and -surface interactions. Our results demonstrate rich phase behavior obtainable from a single, highly patchy protein when interactions acting over multiple length scales are exploited and predict unusual bulk-scale properties for protein-based materials that ensue from such control.

Suggested Citation

  • Shuai Zhang & Robert G. Alberstein & James J. Yoreo & F. Akif Tezcan, 2020. "Assembly of a patchy protein into variable 2D lattices via tunable multiscale interactions," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17562-1
    DOI: 10.1038/s41467-020-17562-1
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    Cited by:

    1. Sanahan Vijayakumar & Robert G. Alberstein & Zhiyin Zhang & Yi-Sheng Lu & Adriano Chan & Charlotte E. Wahl & James S. Ha & Deborah E. Hunka & Gerry R. Boss & Michael J. Sailor & F. Akif Tezcan, 2024. "Designed 2D protein crystals as dynamic molecular gatekeepers for a solid-state device," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Minghui Tan & Pan Tian & Qian Zhang & Guiqiang Zhu & Yuchen Liu & Mengjiao Cheng & Feng Shi, 2022. "Self-sorting in macroscopic supramolecular self-assembly via additive effects of capillary and magnetic forces," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    3. Yufei Wang & Yilong Zhou & Quanpeng Yang & Rourav Basak & Yu Xie & Dong Le & Alexander D. Fuqua & Wade Shipley & Zachary Yam & Alex Frano & Gaurav Arya & Andrea R. Tao, 2024. "Self-assembly of nanocrystal checkerboard patterns via non-specific interactions," Nature Communications, Nature, vol. 15(1), pages 1-9, December.

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