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Bottom-up construction of chiral metal-peptide assemblies from metal cluster motifs

Author

Listed:
  • Pei-Ming Cheng

    (State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University)

  • Tao Jia

    (State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University)

  • Chong-Yang Li

    (State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University)

  • Ming-Qiang Qi

    (State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University)

  • Ming-Hao Du

    (State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University)

  • Hai-Feng Su

    (State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University)

  • Qing-Fu Sun

    (Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences)

  • La-Sheng Long

    (State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University)

  • Lan-Sun Zheng

    (State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University)

  • Xiang-Jian Kong

    (State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University)

Abstract

The exploration of artificial metal-peptide assemblies (MPAs) is one of the most exciting fields because of their great potential for simulating the dynamics and functionality of natural proteins. However, unfavorable enthalpy changes make forming discrete complexes with large and adaptable cavities from flexible peptide ligands challenging. Here, we present a strategy integrating metal-cluster building blocks and peptides to create chiral metal-peptide assemblies and get a family of enantiopure [R-/S-Ni3L2]n (n = 2, 3, 6) MPAs, including the R-/S-Ni6L4 capsule, the S-Ni9L6 trigonal prism, and the R-/S-Ni18L12 octahedron cage. X-ray crystallography shows MPA formation reactions are highly solvent-condition-dependent, resulting in significant changes in ligand conformation and discrete cavity sizes. Moreover, we demonstrate that a structure transformation from Ni18L12 to Ni9L6 in the presence of benzopyrone molecules depends on the peptide conformational selection in crystallization. This work reveals that a metal-cluster building block approach enables facile bottom-up construction of artificial metal-peptide assemblies.

Suggested Citation

  • Pei-Ming Cheng & Tao Jia & Chong-Yang Li & Ming-Qiang Qi & Ming-Hao Du & Hai-Feng Su & Qing-Fu Sun & La-Sheng Long & Lan-Sun Zheng & Xiang-Jian Kong, 2024. "Bottom-up construction of chiral metal-peptide assemblies from metal cluster motifs," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53320-3
    DOI: 10.1038/s41467-024-53320-3
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    References listed on IDEAS

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    1. Alexandros P. Katsoulidis & Dmytro Antypov & George F. S. Whitehead & Elliot J. Carrington & Dave J. Adams & Neil G. Berry & George R. Darling & Matthew S. Dyer & Matthew J. Rosseinsky, 2019. "Chemical control of structure and guest uptake by a conformationally mobile porous material," Nature, Nature, vol. 565(7738), pages 213-217, January.
    2. Eyal Golub & Rohit H. Subramanian & Julian Esselborn & Robert G. Alberstein & Jake B. Bailey & Jerika A. Chiong & Xiaodong Yan & Timothy Booth & Timothy S. Baker & F. Akif Tezcan, 2020. "Constructing protein polyhedra via orthogonal chemical interactions," Nature, Nature, vol. 578(7793), pages 172-176, February.
    3. Yi Lu & Natasha Yeung & Nathan Sieracki & Nicholas M. Marshall, 2009. "Design of functional metalloproteins," Nature, Nature, vol. 460(7257), pages 855-862, August.
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