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Genetic mapping and evolutionary analysis of human-expanded cognitive networks

Author

Listed:
  • Yongbin Wei

    (Vrije Universiteit Amsterdam)

  • Siemon C. de Lange

    (Vrije Universiteit Amsterdam)

  • Lianne H. Scholtens

    (Vrije Universiteit Amsterdam)

  • Kyoko Watanabe

    (Vrije Universiteit Amsterdam)

  • Dirk Jan Ardesch

    (Vrije Universiteit Amsterdam)

  • Philip R. Jansen

    (Vrije Universiteit Amsterdam
    Erasmus Medical Center)

  • Jeanne E. Savage

    (Vrije Universiteit Amsterdam)

  • Longchuan Li

    (Emory University School of Medicine)

  • Todd M. Preuss

    (Emory University
    Emory University
    Emory University)

  • James K. Rilling

    (Emory University
    Emory University
    Emory University
    Emory University)

  • Danielle Posthuma

    (Vrije Universiteit Amsterdam
    Amsterdam UMC)

  • Martijn P. van den Heuvel

    (Vrije Universiteit Amsterdam
    Amsterdam UMC)

Abstract

Cognitive brain networks such as the default-mode network (DMN), frontoparietal network, and salience network, are key functional networks of the human brain. Here we show that the rapid evolutionary cortical expansion of cognitive networks in the human brain, and most pronounced the DMN, runs parallel with high expression of human-accelerated genes (HAR genes). Using comparative transcriptomics analysis, we present that HAR genes are differentially more expressed in higher-order cognitive networks in humans compared to chimpanzees and macaques and that genes with high expression in the DMN are involved in synapse and dendrite formation. Moreover, HAR and DMN genes show significant associations with individual variations in DMN functional activity, intelligence, sociability, and mental conditions such as schizophrenia and autism. Our results suggest that the expansion of higher-order functional networks subserving increasing cognitive properties has been an important locus of genetic changes in recent human brain evolution.

Suggested Citation

  • Yongbin Wei & Siemon C. de Lange & Lianne H. Scholtens & Kyoko Watanabe & Dirk Jan Ardesch & Philip R. Jansen & Jeanne E. Savage & Longchuan Li & Todd M. Preuss & James K. Rilling & Danielle Posthuma , 2019. "Genetic mapping and evolutionary analysis of human-expanded cognitive networks," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12764-8
    DOI: 10.1038/s41467-019-12764-8
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    Cited by:

    1. Stan L. W. Driessens & Anna A. Galakhova & Djai B. Heyer & Isabel J. Pieterse & René Wilbers & Eline J. Mertens & Femke Waleboer & Tim S. Heistek & Loet Coenen & Julia R. Meijer & Sander Idema & Phili, 2023. "Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Xinru Zhang & Bohao Fang & Yi-Fei Huang, 2023. "Transcription factor binding sites are frequently under accelerated evolution in primates," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Peñaherrera-Aguirre, Mateo & Sarraf, Matthew A. & Woodley of Menie, Michael A. & Miller, Geoffrey F., 2023. "The ten-million-year explosion: Paleocognitive reconstructions of domain-general cognitive ability (G) in extinct primates," Intelligence, Elsevier, vol. 101(C).
    4. Sofie L. Valk & Ting Xu & Casey Paquola & Bo-yong Park & Richard A. I. Bethlehem & Reinder Vos de Wael & Jessica Royer & Shahrzad Kharabian Masouleh & Şeyma Bayrak & Peter Kochunov & B. T. Thomas Yeo , 2022. "Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    5. Nicole Eichert & Jordan DeKraker & Amy F. D. Howard & Istvan N. Huszar & Silei Zhu & Jérôme Sallet & Karla L. Miller & Rogier B. Mars & Saad Jbabdi & Boris C. Bernhardt, 2024. "Hippocampal connectivity patterns echo macroscale cortical evolution in the primate brain," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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