IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v476y2011i7361d10.1038_nature10287.html
   My bibliography  Save this article

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

Author

Listed:
  • Jason S. Snyder

    (National Institute of Mental Health, National Institutes of Health)

  • Amélie Soumier

    (National Institute of Mental Health, National Institutes of Health)

  • Michelle Brewer

    (National Institute of Mental Health, National Institutes of Health)

  • James Pickel

    (National Institute of Mental Health, National Institutes of Health)

  • Heather A. Cameron

    (National Institute of Mental Health, National Institutes of Health)

Abstract

Suppressed neurogenesis link to depression Decreased neurogenesis in the hippocampus, a brain region densely populated with receptors for stress hormones, has been implicated in the pathogenesis of anxiety and depression, but direct evidence for this role has been lacking. Snyder et al. show that specifically inhibiting adult neurogenesis in mice disrupts endocrine and behavioural stress responses, and also increases multiple depression-associated behaviours. These data implicate adult-born hippocampal neurons in regulation of the stress response and establish a direct link to depressive symptoms for the first time.

Suggested Citation

  • Jason S. Snyder & Amélie Soumier & Michelle Brewer & James Pickel & Heather A. Cameron, 2011. "Adult hippocampal neurogenesis buffers stress responses and depressive behaviour," Nature, Nature, vol. 476(7361), pages 458-461, August.
    • Handle: RePEc:nat:nature:v:476:y:2011:i:7361:d:10.1038_nature10287
    DOI: 10.1038/nature10287
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10287
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10287?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. James O Groves & Isla Leslie & Guo-Jen Huang & Stephen B McHugh & Amy Taylor & Richard Mott & Marcus Munafò & David M Bannerman & Jonathan Flint, 2013. "Ablating Adult Neurogenesis in the Rat Has No Effect on Spatial Processing: Evidence from a Novel Pharmacogenetic Model," PLOS Genetics, Public Library of Science, vol. 9(9), pages 1-16, September.
    2. Masayuki Kikkawa & Akiyoshi Shimura & Kazuki Nakajima & Chihiro Morishita & Mina Honyashiki & Yu Tamada & Shinji Higashi & Masahiko Ichiki & Takeshi Inoue & Jiro Masuya, 2023. "Mediating Effects of Trait Anxiety and State Anxiety on the Effects of Physical Activity on Depressive Symptoms," IJERPH, MDPI, vol. 20(7), pages 1-12, March.
    3. Reidun Aesoy & Haruna Muwonge & Kathrine S Asrud & Misbah Sabir & Solveig L Witsoe & Ronja Bjornstad & Reidun K Kopperud & Erling A Hoivik & Stein Ove Doskeland & Marit Bakke, 2018. "Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice," PLOS ONE, Public Library of Science, vol. 13(7), pages 1-25, July.
    4. Liang Fang & Chanjuan Zhou & Shunjie Bai & Chenglong Huang & Junxi Pan & Ling Wang & Xinfa Wang & Qiang Mao & Lu Sun & Peng Xie, 2015. "The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Depression: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-11, July.
    5. Lan Yan & Fengzhen Yang & Yajie Wang & Lingling Shi & Mei Wang & Diran Yang & Wenjing Wang & Yanbin Jia & Kwok-Fai So & Li Zhang, 2024. "Stress increases hepatic release of lipocalin 2 which contributes to anxiety-like behavior in mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    6. Nicole Eichert & Jordan DeKraker & Amy F. D. Howard & Istvan N. Huszar & Silei Zhu & Jérôme Sallet & Karla L. Miller & Rogier B. Mars & Saad Jbabdi & Boris C. Bernhardt, 2024. "Hippocampal connectivity patterns echo macroscale cortical evolution in the primate brain," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:476:y:2011:i:7361:d:10.1038_nature10287. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.