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The hippocampal CA2 region is essential for social memory

Author

Listed:
  • Frederick L. Hitti

    (Kavli Institute, College of Physicians and Surgeons, Columbia University 1051 Riverside Drive)

  • Steven A. Siegelbaum

    (Kavli Institute, College of Physicians and Surgeons, Columbia University 1051 Riverside Drive
    Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University 1051 Riverside Drive)

Abstract

CA2 neuron inactivation leads to a severe deficit in social memory, while having little effect on other well-known hippocampal functions such as contextual or spatial memory.

Suggested Citation

  • Frederick L. Hitti & Steven A. Siegelbaum, 2014. "The hippocampal CA2 region is essential for social memory," Nature, Nature, vol. 508(7494), pages 88-92, April.
    • Handle: RePEc:nat:nature:v:508:y:2014:i:7494:d:10.1038_nature13028
    DOI: 10.1038/nature13028
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    Cited by:

    1. Yuto Hasegawa & Juhyun Kim & Gianluca Ursini & Yan Jouroukhin & Xiaolei Zhu & Yu Miyahara & Feiyi Xiong & Samskruthi Madireddy & Mizuho Obayashi & Beat Lutz & Akira Sawa & Solange P. Brown & Mikhail V, 2023. "Microglial cannabinoid receptor type 1 mediates social memory deficits in mice produced by adolescent THC exposure and 16p11.2 duplication," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Chinnakkaruppan Adaikkan & Justin Joseph & Georgios Foustoukos & Jun Wang & Denis Polygalov & Roman Boehringer & Steven J. Middleton & Arthur J. Y. Huang & Li-Huei Tsai & Thomas J. McHugh, 2024. "Silencing CA1 pyramidal cells output reveals the role of feedback inhibition in hippocampal oscillations," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Zihao Chen & Yechao Han & Zheng Ma & Xinnian Wang & Surui Xu & Yong Tang & Alexei L. Vyssotski & Bailu Si & Yang Zhan, 2024. "A prefrontal-thalamic circuit encodes social information for social recognition," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. David Wolf & Renée Hartig & Yi Zhuo & Max F. Scheller & Mirko Articus & Marcel Moor & Valery Grinevich & Christiane Linster & Eleonora Russo & Wolfgang Weber-Fahr & Jonathan R. Reinwald & Wolfgang Kel, 2024. "Oxytocin induces the formation of distinctive cortical representations and cognitions biased toward familiar mice," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    5. Myung Chung & Katsutoshi Imanaka & Ziyan Huang & Akiyuki Watarai & Mu-Yun Wang & Kentaro Tao & Hirotaka Ejima & Tomomi Aida & Guoping Feng & Teruhiro Okuyama, 2024. "Conditional knockout of Shank3 in the ventral CA1 by quantitative in vivo genome-editing impairs social memory in mice," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    6. Elise C. Cope & Samantha H. Wang & Renée C. Waters & Isha R. Gore & Betsy Vasquez & Blake J. Laham & Elizabeth Gould, 2023. "Activation of the CA2-ventral CA1 pathway reverses social discrimination dysfunction in Shank3B knockout mice," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    7. Eunji Kong & Kyu-Hee Lee & Jongrok Do & Pilhan Kim & Doyun Lee, 2023. "Dynamic and stable hippocampal representations of social identity and reward expectation support associative social memory in male mice," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    8. Nicole Eichert & Jordan DeKraker & Amy F. D. Howard & Istvan N. Huszar & Silei Zhu & Jérôme Sallet & Karla L. Miller & Rogier B. Mars & Saad Jbabdi & Boris C. Bernhardt, 2024. "Hippocampal connectivity patterns echo macroscale cortical evolution in the primate brain," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    9. Owen Y. Chao & Salil Saurav Pathak & Hao Zhang & George J. Augustine & Jason M. Christie & Chikako Kikuchi & Hiroki Taniguchi & Yi-Mei Yang, 2023. "Social memory deficit caused by dysregulation of the cerebellar vermis," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    10. Biao Zhang & Shuqin Zhang & Shihua Zhang, 2024. "Whole brain alignment of spatial transcriptomics between humans and mice with BrainAlign," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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