IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-48250-z.html
   My bibliography  Save this article

Lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation

Author

Listed:
  • Qian Wang

    (Sichuan University)

  • Yusheng Zhang

    (Sichuan University)

  • Haoyue Xue

    (Sichuan University)

  • Yushun Zeng

    (Los Angeles)

  • Gengxi Lu

    (Los Angeles)

  • Hongsong Fan

    (Sichuan University)

  • Laiming Jiang

    (Sichuan University)

  • Jiagang Wu

    (Sichuan University)

Abstract

Ultrasound-driven bioelectronics could offer a wireless scheme with sustainable power supply; however, current ultrasound implantable systems present critical challenges in biocompatibility and harvesting performance related to lead/lead-free piezoelectric materials and devices. Here, we report a lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation, which integrates two developed lead-free sandwich porous 1-3-type piezoelectric composite elements with enhanced harvesting performance in a flexible printed circuit board. The implant is ultrasonically powered through a portable external dual-frequency transducer and generates programmable biphasic stimulus pulses in clinically relevant frequencies. Furthermore, we demonstrate ultrasound-driven implants for long-term biosafety therapy in deep brain stimulation through an epileptic rodent model. With biocompatibility and improved electrical performance, the lead-free materials and devices presented here could provide a promising platform for developing implantable ultrasonic electronics in the future.

Suggested Citation

  • Qian Wang & Yusheng Zhang & Haoyue Xue & Yushun Zeng & Gengxi Lu & Hongsong Fan & Laiming Jiang & Jiagang Wu, 2024. "Lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48250-z
    DOI: 10.1038/s41467-024-48250-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-48250-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-48250-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Rebecca G. Canter & Jay Penney & Li-Huei Tsai, 2016. "The road to restoring neural circuits for the treatment of Alzheimer's disease," Nature, Nature, vol. 539(7628), pages 187-196, November.
    2. Hongjie Hu & Hao Huang & Mohan Li & Xiaoxiang Gao & Lu Yin & Ruixiang Qi & Ray S. Wu & Xiangjun Chen & Yuxiang Ma & Keren Shi & Chenghai Li & Timothy M. Maus & Brady Huang & Chengchangfeng Lu & Muyang, 2023. "A wearable cardiac ultrasound imager," Nature, Nature, vol. 613(7945), pages 667-675, January.
    3. Shuai Yang & Jinglei Li & Yao Liu & Mingwen Wang & Liao Qiao & Xiangyu Gao & Yunfei Chang & Hongliang Du & Zhuo Xu & Shujun Zhang & Fei Li, 2021. "Textured ferroelectric ceramics with high electromechanical coupling factors over a broad temperature range," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    4. Choong Yeon Kim & Min Jeong Ku & Raza Qazi & Hong Jae Nam & Jong Woo Park & Kum Seok Nam & Shane Oh & Inho Kang & Jae-Hyung Jang & Wha Young Kim & Jeong-Hoon Kim & Jae-Woong Jeong, 2021. "Soft subdermal implant capable of wireless battery charging and programmable controls for applications in optogenetics," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Alp Timucin Toymus & Umut Can Yener & Emine Bardakci & Özgür Deniz Temel & Ersin Koseoglu & Dincay Akcoren & Burak Eminoglu & Mohsin Ali & Rasim Kilic & Tufan Tarcan & Levent Beker, 2024. "An integrated and flexible ultrasonic device for continuous bladder volume monitoring," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    2. Yangshuang Bian & Mingliang Zhu & Chengyu Wang & Kai Liu & Wenkang Shi & Zhiheng Zhu & Mingcong Qin & Fan Zhang & Zhiyuan Zhao & Hanlin Wang & Yunqi Liu & Yunlong Guo, 2024. "A detachable interface for stable low-voltage stretchable transistor arrays and high-resolution X-ray imaging," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    3. Ana Sofía Ríos & Simón Oxenford & Clemens Neudorfer & Konstantin Butenko & Ningfei Li & Nanditha Rajamani & Alexandre Boutet & Gavin J. B. Elias & Jurgen Germann & Aaron Loh & Wissam Deeb & Fuyixue Wa, 2022. "Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer’s disease," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Jian Li & Shengxin Jia & Dengfeng Li & Lung Chow & Qiang Zhang & Yiyuan Yang & Xiao Bai & Qingao Qu & Yuyu Gao & Zhiyuan Li & Zongze Li & Rui Shi & Binbin Zhang & Ya Huang & Xinyu Pan & Yue Hu & Zhan , 2024. "Wearable bio-adhesive metal detector array (BioMDA) for spinal implants," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    5. Qian, Suxin & Yao, Sijia & Wang, Yao & Yuan, Lifen & Yu, Jianlin, 2022. "Harvesting low-grade heat by coupling regenerative shape-memory actuator and piezoelectric generator," Applied Energy, Elsevier, vol. 322(C).
    6. Yongke Yan & Liwei D. Geng & Hairui Liu & Haoyang Leng & Xiaotian Li & Yu U. Wang & Shashank Priya, 2022. "Near-ideal electromechanical coupling in textured piezoelectric ceramics," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    7. Yuanxi Chen & Shuangxia Niu & Weinong Fu & Hongjian Lin, 2024. "Modelling of negative equivalent magnetic reluctance structure and its application in weak-coupling wireless power transmission," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    8. Qingtao Sun & Jianping Zhang & Anan Li & Mei Yao & Guangcai Liu & Siqi Chen & Yue Luo & Zhi Wang & Hui Gong & Xiangning Li & Qingming Luo, 2022. "Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer’s disease," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    9. Vidal, João V. & Rolo, Pedro & Carneiro, Pedro M.R. & Peres, Inês & Kholkin, Andrei L. & Soares dos Santos, Marco P., 2022. "Automated electromagnetic generator with self-adaptive structure by coil switching," Applied Energy, Elsevier, vol. 325(C).
    10. Bin Yang & Haonan Wang & Jilie Kong & Xueen Fang, 2024. "Long-term monitoring of ultratrace nucleic acids using tetrahedral nanostructure-based NgAgo on wearable microneedles," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    11. Chaojie Yu & Mingyue Shi & Shaoshuai He & Mengmeng Yao & Hong Sun & Zhiwei Yue & Yuwei Qiu & Baijun Liu & Lei Liang & Zhongming Zhao & Fanglian Yao & Hong Zhang & Junjie Li, 2023. "Chronological adhesive cardiac patch for synchronous mechanophysiological monitoring and electrocoupling therapy," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    12. Paul L. M. J. Neer & Laurens C. J. M. Peters & Roy G. F. A. Verbeek & Bart Peeters & Gerard Haas & Lars Hörchens & Laurent Fillinger & Thijs Schrama & Egon J. W. Merks-Swolfs & Kaj Gijsbertse & Anne E, 2024. "Flexible large-area ultrasound arrays for medical applications made using embossed polymer structures," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    13. Ayuto Kodama & Yasuhiro Suzuki & Kazuki Sakuraba & Yu Kume & Hidetaka Ota, 2022. "The Effect of Deep Micro Vibrotactile Stimulation on Cognitive Function of Mild Cognitive Impairment and Mild Dementia," IJERPH, MDPI, vol. 19(7), pages 1-10, March.
    14. Li, Huixia & Zhao, Hongyong, 2022. "Mathematical model of Alzheimer’s disease with prion proteins interactions and treatment," Applied Mathematics and Computation, Elsevier, vol. 433(C).
    15. Lizhu Li & Lihui Lu & Yuqi Ren & Guo Tang & Yu Zhao & Xue Cai & Zhao Shi & He Ding & Changbo Liu & Dali Cheng & Yang Xie & Huachun Wang & Xin Fu & Lan Yin & Minmin Luo & Xing Sheng, 2022. "Colocalized, bidirectional optogenetic modulations in freely behaving mice with a wireless dual-color optoelectronic probe," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    16. Young-Jin Park & Ji-Eun Kim & Kyung-Min Na & Ki-Dong Yang & Kyung-Hwan Cho, 2021. "Optimization and Analysis of Multilayer Planar Spiral Coils for the Application of Magnetic Resonance Wireless Power Transfer to Wearable Devices," Energies, MDPI, vol. 14(16), pages 1-19, August.
    17. Gengxi Lu & Chen Gong & Yizhe Sun & Xuejun Qian & Deepthi S. Rajendran Nair & Runze Li & Yushun Zeng & Jie Ji & Junhang Zhang & Haochen Kang & Laiming Jiang & Jiawen Chen & Chi-Feng Chang & Biju B. Th, 2024. "Noninvasive imaging-guided ultrasonic neurostimulation with arbitrary 2D patterns and its application for high-quality vision restoration," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48250-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.