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Lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation

Author

Listed:
  • Qian Wang

    (Sichuan University)

  • Yusheng Zhang

    (Sichuan University)

  • Haoyue Xue

    (Sichuan University)

  • Yushun Zeng

    (Los Angeles)

  • Gengxi Lu

    (Los Angeles)

  • Hongsong Fan

    (Sichuan University)

  • Laiming Jiang

    (Sichuan University)

  • Jiagang Wu

    (Sichuan University)

Abstract

Ultrasound-driven bioelectronics could offer a wireless scheme with sustainable power supply; however, current ultrasound implantable systems present critical challenges in biocompatibility and harvesting performance related to lead/lead-free piezoelectric materials and devices. Here, we report a lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation, which integrates two developed lead-free sandwich porous 1-3-type piezoelectric composite elements with enhanced harvesting performance in a flexible printed circuit board. The implant is ultrasonically powered through a portable external dual-frequency transducer and generates programmable biphasic stimulus pulses in clinically relevant frequencies. Furthermore, we demonstrate ultrasound-driven implants for long-term biosafety therapy in deep brain stimulation through an epileptic rodent model. With biocompatibility and improved electrical performance, the lead-free materials and devices presented here could provide a promising platform for developing implantable ultrasonic electronics in the future.

Suggested Citation

  • Qian Wang & Yusheng Zhang & Haoyue Xue & Yushun Zeng & Gengxi Lu & Hongsong Fan & Laiming Jiang & Jiagang Wu, 2024. "Lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48250-z
    DOI: 10.1038/s41467-024-48250-z
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