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The road to restoring neural circuits for the treatment of Alzheimer's disease

Author

Listed:
  • Rebecca G. Canter

    (The Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Jay Penney

    (The Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Li-Huei Tsai

    (The Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    The Broad Institute of MIT and Harvard)

Abstract

Alzheimer's disease is a progressive loss of memory and cognition, for which there is no cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's disease, treatment strategies targeted at reducing amyloid-have failed to reverse cognitive symptoms. These clinical findings suggest that cognitive decline is the result of a complex pathophysiology and that targeting amyloid-alone may not be sufficient to treat Alzheimer's disease. Instead, a broad outlook on neural-circuit-damaging processes may yield insights into new therapeutic strategies for curing memory loss in the disease.

Suggested Citation

  • Rebecca G. Canter & Jay Penney & Li-Huei Tsai, 2016. "The road to restoring neural circuits for the treatment of Alzheimer's disease," Nature, Nature, vol. 539(7628), pages 187-196, November.
    • Handle: RePEc:nat:nature:v:539:y:2016:i:7628:d:10.1038_nature20412
    DOI: 10.1038/nature20412
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    Cited by:

    1. Li, Huixia & Zhao, Hongyong, 2022. "Mathematical model of Alzheimer’s disease with prion proteins interactions and treatment," Applied Mathematics and Computation, Elsevier, vol. 433(C).
    2. Qian Wang & Yusheng Zhang & Haoyue Xue & Yushun Zeng & Gengxi Lu & Hongsong Fan & Laiming Jiang & Jiagang Wu, 2024. "Lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Ana Sofía Ríos & Simón Oxenford & Clemens Neudorfer & Konstantin Butenko & Ningfei Li & Nanditha Rajamani & Alexandre Boutet & Gavin J. B. Elias & Jurgen Germann & Aaron Loh & Wissam Deeb & Fuyixue Wa, 2022. "Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer’s disease," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Ayuto Kodama & Yasuhiro Suzuki & Kazuki Sakuraba & Yu Kume & Hidetaka Ota, 2022. "The Effect of Deep Micro Vibrotactile Stimulation on Cognitive Function of Mild Cognitive Impairment and Mild Dementia," IJERPH, MDPI, vol. 19(7), pages 1-10, March.
    5. Qingtao Sun & Jianping Zhang & Anan Li & Mei Yao & Guangcai Liu & Siqi Chen & Yue Luo & Zhi Wang & Hui Gong & Xiangning Li & Qingming Luo, 2022. "Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer’s disease," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

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