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Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer’s disease

Author

Listed:
  • Ana Sofía Ríos

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Simón Oxenford

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Clemens Neudorfer

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Konstantin Butenko

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Ningfei Li

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Nanditha Rajamani

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Alexandre Boutet

    (University Health Network and University of Toronto
    University of Toronto
    University of Toronto)

  • Gavin J. B. Elias

    (University Health Network and University of Toronto
    University of Toronto)

  • Jurgen Germann

    (University Health Network and University of Toronto
    University of Toronto)

  • Aaron Loh

    (University Health Network and University of Toronto
    University of Toronto)

  • Wissam Deeb

    (UMass Chan Medical School, Department of Neurology
    UMass Memorial Health, Department of Neurology)

  • Fuyixue Wang

    (Harvard Medical School, Massachusetts General Hospital
    Harvard-MIT Health Sciences and Technology, MIT)

  • Kawin Setsompop

    (Harvard Medical School, Massachusetts General Hospital
    Harvard-MIT Health Sciences and Technology, MIT
    Stanford University)

  • Bryan Salvato

    (University of Florida Health Jacksonville)

  • Leonardo Brito de Almeida

    (University of Florida)

  • Kelly D. Foote

    (University of Florida)

  • Robert Amaral

    (Cerebral Imaging Centre, Douglas Research Centre)

  • Paul B. Rosenberg

    (School of Medicine, Johns Hopkins University)

  • David F. Tang-Wai

    (University of Toronto
    University Health Network and University of Toronto)

  • David A. Wolk

    (University of Pennsylvania)

  • Anna D. Burke

    (Barrow Neurological Institute)

  • Stephen Salloway

    (Alpert Medical School of Brown University
    Butler Hospital)

  • Marwan N. Sabbagh

    (Barrow Neurological Institute)

  • M. Mallar Chakravarty

    (Cerebral Imaging Centre, Douglas Research Centre
    McGill University
    McGill University)

  • Gwenn S. Smith

    (School of Medicine, Johns Hopkins University)

  • Constantine G. Lyketsos

    (School of Medicine, Johns Hopkins University)

  • Michael S. Okun

    (University of Florida)

  • William S. Anderson

    (Johns Hopkins School of Medicine)

  • Zoltan Mari

    (Johns Hopkins School of Medicine
    Cleveland Clinic Lou Ruvo Center for Brain Health)

  • Francisco A. Ponce

    (Barrow Neurological Institute)

  • Andres M. Lozano

    (University Health Network and University of Toronto
    University of Toronto)

  • Andreas Horn

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    Brigham and Women’s Hospital
    Massachusetts General Hospital)

Abstract

Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer’s Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some patients but deteriorated in others. This could be explained by variance in electrode placement leading to differential engagement of neural circuits. To investigate this, we performed a post-hoc analysis on a multi-center cohort of 46 patients with DBS to the fornix (NCT00658125, NCT01608061). Using normative structural and functional connectivity data, we found that stimulation of the circuit of Papez and stria terminalis robustly associated with cognitive improvement (R = 0.53, p

Suggested Citation

  • Ana Sofía Ríos & Simón Oxenford & Clemens Neudorfer & Konstantin Butenko & Ningfei Li & Nanditha Rajamani & Alexandre Boutet & Gavin J. B. Elias & Jurgen Germann & Aaron Loh & Wissam Deeb & Fuyixue Wa, 2022. "Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer’s disease," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34510-3
    DOI: 10.1038/s41467-022-34510-3
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    References listed on IDEAS

    as
    1. Rebecca G. Canter & Jay Penney & Li-Huei Tsai, 2016. "The road to restoring neural circuits for the treatment of Alzheimer's disease," Nature, Nature, vol. 539(7628), pages 187-196, November.
    2. Timothy N Rubin & Oluwasanmi Koyejo & Krzysztof J Gorgolewski & Michael N Jones & Russell A Poldrack & Tal Yarkoni, 2017. "Decoding brain activity using a large-scale probabilistic functional-anatomical atlas of human cognition," PLOS Computational Biology, Public Library of Science, vol. 13(10), pages 1-24, October.
    3. Hannah F. Iaccarino & Annabelle C. Singer & Anthony J. Martorell & Andrii Rudenko & Fan Gao & Tyler Z. Gillingham & Hansruedi Mathys & Jinsoo Seo & Oleg Kritskiy & Fatema Abdurrob & Chinnakkaruppan Ad, 2016. "Gamma frequency entrainment attenuates amyloid load and modifies microglia," Nature, Nature, vol. 540(7632), pages 230-235, December.
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