IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-34510-3.html
   My bibliography  Save this article

Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer’s disease

Author

Listed:
  • Ana Sofía Ríos

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Simón Oxenford

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Clemens Neudorfer

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Konstantin Butenko

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Ningfei Li

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Nanditha Rajamani

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Alexandre Boutet

    (University Health Network and University of Toronto
    University of Toronto
    University of Toronto)

  • Gavin J. B. Elias

    (University Health Network and University of Toronto
    University of Toronto)

  • Jurgen Germann

    (University Health Network and University of Toronto
    University of Toronto)

  • Aaron Loh

    (University Health Network and University of Toronto
    University of Toronto)

  • Wissam Deeb

    (UMass Chan Medical School, Department of Neurology
    UMass Memorial Health, Department of Neurology)

  • Fuyixue Wang

    (Harvard Medical School, Massachusetts General Hospital
    Harvard-MIT Health Sciences and Technology, MIT)

  • Kawin Setsompop

    (Harvard Medical School, Massachusetts General Hospital
    Harvard-MIT Health Sciences and Technology, MIT
    Stanford University)

  • Bryan Salvato

    (University of Florida Health Jacksonville)

  • Leonardo Brito de Almeida

    (University of Florida)

  • Kelly D. Foote

    (University of Florida)

  • Robert Amaral

    (Cerebral Imaging Centre, Douglas Research Centre)

  • Paul B. Rosenberg

    (School of Medicine, Johns Hopkins University)

  • David F. Tang-Wai

    (University of Toronto
    University Health Network and University of Toronto)

  • David A. Wolk

    (University of Pennsylvania)

  • Anna D. Burke

    (Barrow Neurological Institute)

  • Stephen Salloway

    (Alpert Medical School of Brown University
    Butler Hospital)

  • Marwan N. Sabbagh

    (Barrow Neurological Institute)

  • M. Mallar Chakravarty

    (Cerebral Imaging Centre, Douglas Research Centre
    McGill University
    McGill University)

  • Gwenn S. Smith

    (School of Medicine, Johns Hopkins University)

  • Constantine G. Lyketsos

    (School of Medicine, Johns Hopkins University)

  • Michael S. Okun

    (University of Florida)

  • William S. Anderson

    (Johns Hopkins School of Medicine)

  • Zoltan Mari

    (Johns Hopkins School of Medicine
    Cleveland Clinic Lou Ruvo Center for Brain Health)

  • Francisco A. Ponce

    (Barrow Neurological Institute)

  • Andres M. Lozano

    (University Health Network and University of Toronto
    University of Toronto)

  • Andreas Horn

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    Brigham and Women’s Hospital
    Massachusetts General Hospital)

Abstract

Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer’s Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some patients but deteriorated in others. This could be explained by variance in electrode placement leading to differential engagement of neural circuits. To investigate this, we performed a post-hoc analysis on a multi-center cohort of 46 patients with DBS to the fornix (NCT00658125, NCT01608061). Using normative structural and functional connectivity data, we found that stimulation of the circuit of Papez and stria terminalis robustly associated with cognitive improvement (R = 0.53, p

Suggested Citation

  • Ana Sofía Ríos & Simón Oxenford & Clemens Neudorfer & Konstantin Butenko & Ningfei Li & Nanditha Rajamani & Alexandre Boutet & Gavin J. B. Elias & Jurgen Germann & Aaron Loh & Wissam Deeb & Fuyixue Wa, 2022. "Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer’s disease," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34510-3
    DOI: 10.1038/s41467-022-34510-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-34510-3
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-022-34510-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Rebecca G. Canter & Jay Penney & Li-Huei Tsai, 2016. "The road to restoring neural circuits for the treatment of Alzheimer's disease," Nature, Nature, vol. 539(7628), pages 187-196, November.
    2. Timothy N Rubin & Oluwasanmi Koyejo & Krzysztof J Gorgolewski & Michael N Jones & Russell A Poldrack & Tal Yarkoni, 2017. "Decoding brain activity using a large-scale probabilistic functional-anatomical atlas of human cognition," PLOS Computational Biology, Public Library of Science, vol. 13(10), pages 1-24, October.
    3. Hunter F. Iaccarino & Annabelle C. Singer & Anthony J. Martorell & Andrii Rudenko & Fan Gao & Tyler Z. Gillingham & Hansruedi Mathys & Jinsoo Seo & Oleg Kritskiy & Fatema Abdurrob & Chinnakkaruppan Ad, 2016. "Gamma frequency entrainment attenuates amyloid load and modifies microglia," Nature, Nature, vol. 540(7632), pages 230-235, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ayuto Kodama & Yasuhiro Suzuki & Kazuki Sakuraba & Yu Kume & Hidetaka Ota, 2022. "The Effect of Deep Micro Vibrotactile Stimulation on Cognitive Function of Mild Cognitive Impairment and Mild Dementia," IJERPH, MDPI, vol. 19(7), pages 1-10, March.
    2. Ankita Sengupta & Sanjna Banerjee & Suhas Ganesh & Shrey Grover & Devarajan Sridharan, 2024. "The right posterior parietal cortex mediates spatial reorienting of attentional choice bias," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    3. Daniela Rodrigues-Amorim & P. Lorenzo Bozzelli & TaeHyun Kim & Liwang Liu & Oliver Gibson & Cheng-Yi Yang & Mitchell H. Murdock & Fabiola Galiana-Melendez & Brooke Schatz & Alexis Davison & Md Rezaul , 2024. "Multisensory gamma stimulation mitigates the effects of demyelination induced by cuprizone in male mice," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Jinyoung Kang & Margaret E. Schroeder & Youngmi Lee & Chaitanya Kapoor & Eunah Yu & Tyler B. Tarr & Kat Titterton & Menglong Zeng & Demian Park & Emily Niederst & Donglai Wei & Guoping Feng & Edward S, 2024. "Multiplexed expansion revealing for imaging multiprotein nanostructures in healthy and diseased brain," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    5. Amy Clements-Cortes & Lee Bartel, 2022. "Long-Term Multi-Sensory Gamma Stimulation of Dementia Patients: A Case Series Report," IJERPH, MDPI, vol. 19(23), pages 1-10, November.
    6. Koustav Roy & Xuzhao Zhou & Rintaro Otani & Ping-Chuan Yuan & Shuji Ioka & Kaspar E. Vogt & Tamae Kondo & Nouran H. T. Farag & Haruto Ijiri & Zhaofa Wu & Youhei Chitose & Mao Amezawa & David S. Uygun , 2024. "Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    7. Li, Huixia & Zhao, Hongyong, 2022. "Mathematical model of Alzheimer’s disease with prion proteins interactions and treatment," Applied Mathematics and Computation, Elsevier, vol. 433(C).
    8. Lou T. Blanpain & Eric R. Cole & Emily Chen & James K. Park & Michael Y. Walelign & Robert E. Gross & Brian T. Cabaniss & Jon T. Willie & Annabelle C. Singer, 2024. "Multisensory flicker modulates widespread brain networks and reduces interictal epileptiform discharges," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    9. Joyneel Misra & Srinivas Govinda Surampudi & Manasij Venkatesh & Chirag Limbachia & Joseph Jaja & Luiz Pessoa, 2021. "Learning brain dynamics for decoding and predicting individual differences," PLOS Computational Biology, Public Library of Science, vol. 17(9), pages 1-25, September.
    10. Qingtao Sun & Jianping Zhang & Anan Li & Mei Yao & Guangcai Liu & Siqi Chen & Yue Luo & Zhi Wang & Hui Gong & Xiangning Li & Qingming Luo, 2022. "Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer’s disease," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    11. Qian Wang & Yusheng Zhang & Haoyue Xue & Yushun Zeng & Gengxi Lu & Hongsong Fan & Laiming Jiang & Jiagang Wu, 2024. "Lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    12. D. Jones & V. Lowe & J. Graff-Radford & H. Botha & L. Barnard & D. Wiepert & M. C. Murphy & M. Murray & M. Senjem & J. Gunter & H. Wiste & B. Boeve & D. Knopman & R. Petersen & C. Jack, 2022. "A computational model of neurodegeneration in Alzheimer’s disease," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    13. Thenille Braun Janzen & Denise Paneduro & Larry Picard & Allan Gordon & Lee R Bartel, 2019. "A parallel randomized controlled trial examining the effects of rhythmic sensory stimulation on fibromyalgia symptoms," PLOS ONE, Public Library of Science, vol. 14(3), pages 1-19, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34510-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.