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A wearable cardiac ultrasound imager

Author

Listed:
  • Hongjie Hu

    (University of California San Diego)

  • Hao Huang

    (University of California San Diego)

  • Mohan Li

    (University of California San Diego)

  • Xiaoxiang Gao

    (University of California San Diego)

  • Lu Yin

    (University of California San Diego)

  • Ruixiang Qi

    (University of California San Diego)

  • Ray S. Wu

    (University of California San Diego)

  • Xiangjun Chen

    (University of California San Diego)

  • Yuxiang Ma

    (University of California San Diego
    Massachusetts Institute of Technology)

  • Keren Shi

    (University of California San Diego
    University of California)

  • Chenghai Li

    (University of California San Diego)

  • Timothy M. Maus

    (University of California, San Diego Health Sulpizio Cardiovascular Center)

  • Brady Huang

    (University of California San Diego)

  • Chengchangfeng Lu

    (University of California San Diego)

  • Muyang Lin

    (University of California San Diego)

  • Sai Zhou

    (University of California San Diego)

  • Zhiyuan Lou

    (University of California San Diego)

  • Yue Gu

    (University of California San Diego
    Yale University)

  • Yimu Chen

    (University of California San Diego)

  • Yusheng Lei

    (University of California San Diego
    Stanford University)

  • Xinyu Wang

    (University of California San Diego)

  • Ruotao Wang

    (University of California San Diego)

  • Wentong Yue

    (University of California San Diego)

  • Xinyi Yang

    (University of California San Diego)

  • Yizhou Bian

    (University of California San Diego)

  • Jing Mu

    (University of California San Diego)

  • Geonho Park

    (University of California San Diego)

  • Shu Xiang

    (Softsonics, Inc.)

  • Shengqiang Cai

    (University of California San Diego
    University of California San Diego)

  • Paul W. Corey

    (Sharp Memorial Hospital)

  • Joseph Wang

    (University of California San Diego
    University of California San Diego)

  • Sheng Xu

    (University of California San Diego
    University of California San Diego
    University of California San Diego
    University of California San Diego)

Abstract

Continuous imaging of cardiac functions is highly desirable for the assessment of long-term cardiovascular health, detection of acute cardiac dysfunction and clinical management of critically ill or surgical patients1–4. However, conventional non-invasive approaches to image the cardiac function cannot provide continuous measurements owing to device bulkiness5–11, and existing wearable cardiac devices can only capture signals on the skin12–16. Here we report a wearable ultrasonic device for continuous, real-time and direct cardiac function assessment. We introduce innovations in device design and material fabrication that improve the mechanical coupling between the device and human skin, allowing the left ventricle to be examined from different views during motion. We also develop a deep learning model that automatically extracts the left ventricular volume from the continuous image recording, yielding waveforms of key cardiac performance indices such as stroke volume, cardiac output and ejection fraction. This technology enables dynamic wearable monitoring of cardiac performance with substantially improved accuracy in various environments.

Suggested Citation

  • Hongjie Hu & Hao Huang & Mohan Li & Xiaoxiang Gao & Lu Yin & Ruixiang Qi & Ray S. Wu & Xiangjun Chen & Yuxiang Ma & Keren Shi & Chenghai Li & Timothy M. Maus & Brady Huang & Chengchangfeng Lu & Muyang, 2023. "A wearable cardiac ultrasound imager," Nature, Nature, vol. 613(7945), pages 667-675, January.
  • Handle: RePEc:nat:nature:v:613:y:2023:i:7945:d:10.1038_s41586-022-05498-z
    DOI: 10.1038/s41586-022-05498-z
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    Citations

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    Cited by:

    1. Bin Yang & Haonan Wang & Jilie Kong & Xueen Fang, 2024. "Long-term monitoring of ultratrace nucleic acids using tetrahedral nanostructure-based NgAgo on wearable microneedles," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Qian Wang & Yusheng Zhang & Haoyue Xue & Yushun Zeng & Gengxi Lu & Hongsong Fan & Laiming Jiang & Jiagang Wu, 2024. "Lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Chaojie Yu & Mingyue Shi & Shaoshuai He & Mengmeng Yao & Hong Sun & Zhiwei Yue & Yuwei Qiu & Baijun Liu & Lei Liang & Zhongming Zhao & Fanglian Yao & Hong Zhang & Junjie Li, 2023. "Chronological adhesive cardiac patch for synchronous mechanophysiological monitoring and electrocoupling therapy," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Paul L. M. J. Neer & Laurens C. J. M. Peters & Roy G. F. A. Verbeek & Bart Peeters & Gerard Haas & Lars Hörchens & Laurent Fillinger & Thijs Schrama & Egon J. W. Merks-Swolfs & Kaj Gijsbertse & Anne E, 2024. "Flexible large-area ultrasound arrays for medical applications made using embossed polymer structures," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    5. Yangshuang Bian & Mingliang Zhu & Chengyu Wang & Kai Liu & Wenkang Shi & Zhiheng Zhu & Mingcong Qin & Fan Zhang & Zhiyuan Zhao & Hanlin Wang & Yunqi Liu & Yunlong Guo, 2024. "A detachable interface for stable low-voltage stretchable transistor arrays and high-resolution X-ray imaging," Nature Communications, Nature, vol. 15(1), pages 1-9, December.

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