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Dopamine control of social novelty preference is constrained by an interpeduncular-tegmentum circuit

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  • Susanna Molas

    (Brudnick Neuropsychiatric Research Institute University of Massachusetts Chan Medical School 364 Plantation St, LRB
    University of Colorado Boulder 1480 30th St
    University of Colorado Boulder 1905 Colorado Ave)

  • Timothy G. Freels

    (Brudnick Neuropsychiatric Research Institute University of Massachusetts Chan Medical School 364 Plantation St, LRB)

  • Rubing Zhao-Shea

    (Brudnick Neuropsychiatric Research Institute University of Massachusetts Chan Medical School 364 Plantation St, LRB)

  • Timothy Lee

    (Brudnick Neuropsychiatric Research Institute University of Massachusetts Chan Medical School 364 Plantation St, LRB)

  • Pablo Gimenez-Gomez

    (Brudnick Neuropsychiatric Research Institute University of Massachusetts Chan Medical School 364 Plantation St, LRB)

  • Melanie Barbini

    (Brudnick Neuropsychiatric Research Institute University of Massachusetts Chan Medical School 364 Plantation St, LRB)

  • Gilles E. Martin

    (Brudnick Neuropsychiatric Research Institute University of Massachusetts Chan Medical School 364 Plantation St, LRB)

  • Andrew R. Tapper

    (Brudnick Neuropsychiatric Research Institute University of Massachusetts Chan Medical School 364 Plantation St, LRB)

Abstract

Animals are inherently motivated to explore social novelty cues over familiar ones, resulting in a novelty preference (NP), although the behavioral and circuit bases underlying NP are unclear. Combining calcium and neurotransmitter sensors with fiber photometry and optogenetics in mice, we find that mesolimbic dopamine (DA) neurotransmission is strongly and predominantly activated by social novelty controlling bout length of interaction during NP, a response significantly reduced by familiarity. In contrast, interpeduncular nucleus (IPN) GABAergic neurons that project to the lateral dorsal tegmentum (LDTg) were inhibited by social novelty but activated during terminations with familiar social stimuli. Inhibition of this pathway during NP increased interaction and bout length with familiar social stimuli, while activation reduced interaction and bout length with novel social stimuli via decreasing DA neurotransmission. These data indicate interest towards novel social stimuli is encoded by mesolimbic DA which is dynamically regulated by an IPN→LDTg circuit to control NP.

Suggested Citation

  • Susanna Molas & Timothy G. Freels & Rubing Zhao-Shea & Timothy Lee & Pablo Gimenez-Gomez & Melanie Barbini & Gilles E. Martin & Andrew R. Tapper, 2024. "Dopamine control of social novelty preference is constrained by an interpeduncular-tegmentum circuit," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47255-y
    DOI: 10.1038/s41467-024-47255-y
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    References listed on IDEAS

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