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Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors

Author

Listed:
  • Bárbara Coimbra

    (University of Minho
    ICVS/3B’s–PT Government Associate Laboratory)

  • Carina Soares-Cunha

    (University of Minho
    ICVS/3B’s–PT Government Associate Laboratory)

  • Nivaldo A P Vasconcelos

    (University of Minho
    ICVS/3B’s–PT Government Associate Laboratory
    Federal University of Pernambuco)

  • Ana Verónica Domingues

    (University of Minho
    ICVS/3B’s–PT Government Associate Laboratory)

  • Sónia Borges

    (University of Minho
    ICVS/3B’s–PT Government Associate Laboratory)

  • Nuno Sousa

    (University of Minho
    ICVS/3B’s–PT Government Associate Laboratory
    Clinical Academic Center (2CA-Braga))

  • Ana João Rodrigues

    (University of Minho
    ICVS/3B’s–PT Government Associate Laboratory
    Clinical Academic Center (2CA-Braga))

Abstract

The laterodorsal tegmentum (LDT) is associated with reward considering that it modulates VTA neuronal activity, but recent anatomical evidence shows that the LDT also directly projects to nucleus accumbens (NAc). We show that the majority of LDT-NAc inputs are cholinergic, but there is also GABAergic and glutamatergic innervation; activation of LDT induces a predominantly excitatory response in the NAc. Non-selective optogenetic activation of LDT-NAc projections in rats enhances motivational drive and shifts preference to an otherwise equal reward; whereas inhibition of these projections induces the opposite. Activation of these projections also induces robust place preference. In mice, specific activation of LDT-NAc cholinergic inputs (but not glutamatergic or GABAergic) is sufficient to shift preference, increase motivation, and drive positive reinforcement in different behavioral paradigms. These results provide evidence that LDT-NAc projections play an important role in motivated behaviors and positive reinforcement, and that distinct neuronal populations differentially contribute for these behaviors.

Suggested Citation

  • Bárbara Coimbra & Carina Soares-Cunha & Nivaldo A P Vasconcelos & Ana Verónica Domingues & Sónia Borges & Nuno Sousa & Ana João Rodrigues, 2019. "Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11557-3
    DOI: 10.1038/s41467-019-11557-3
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    Cited by:

    1. Nima Khalighinejad & Neil Garrett & Luke Priestley & Patricia Lockwood & Matthew F. S. Rushworth, 2021. "A habenula-insular circuit encodes the willingness to act," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Zengpeng Han & Nengsong Luo & Wenyu Ma & Xiaodong Liu & Yuxiang Cai & Jiaxin Kou & Jie Wang & Lei Li & Siqi Peng & Zihong Xu & Wen Zhang & Yuxiang Qiu & Yang Wu & Chaohui Ye & Kunzhang Lin & Fuqiang X, 2023. "AAV11 enables efficient retrograde targeting of projection neurons and enhances astrocyte-directed transduction," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Stefano Nardone & Roberto Luca & Antonino Zito & Nataliya Klymko & Dimitris Nicoloutsopoulos & Oren Amsalem & Cory Brannigan & Jon M. Resch & Christopher L. Jacobs & Deepti Pant & Molly Veregge & Hari, 2024. "A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    4. Susanna Molas & Timothy G. Freels & Rubing Zhao-Shea & Timothy Lee & Pablo Gimenez-Gomez & Melanie Barbini & Gilles E. Martin & Andrew R. Tapper, 2024. "Dopamine control of social novelty preference is constrained by an interpeduncular-tegmentum circuit," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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