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A habenula-insular circuit encodes the willingness to act

Author

Listed:
  • Nima Khalighinejad

    (University of Oxford)

  • Neil Garrett

    (University of Oxford
    University of East Anglia)

  • Luke Priestley

    (University of Oxford)

  • Patricia Lockwood

    (University of Oxford
    University of Birmingham)

  • Matthew F. S. Rushworth

    (University of Oxford)

Abstract

The decision that it is worth doing something rather than nothing is a core yet understudied feature of voluntary behaviour. Here we study “willingness to act”, the probability of making a response given the context. Human volunteers encountered opportunities to make effortful actions in order to receive rewards, while watching a movie inside a 7 T MRI scanner. Reward and other context features determined willingness-to-act. Activity in the habenula tracked trial-by-trial variation in participants’ willingness-to-act. The anterior insula encoded individual environment features that determined this willingness. We identify a multi-layered network in which contextual information is encoded in the anterior insula, converges on the habenula, and is then transmitted to the supplementary motor area, where the decision is made to either act or refrain from acting via the nigrostriatal pathway.

Suggested Citation

  • Nima Khalighinejad & Neil Garrett & Luke Priestley & Patricia Lockwood & Matthew F. S. Rushworth, 2021. "A habenula-insular circuit encodes the willingness to act," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26569-1
    DOI: 10.1038/s41467-021-26569-1
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    References listed on IDEAS

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    Cited by:

    1. Jan Grohn & Nima Khalighinejad & Caroline I Jahn & Alessandro Bongioanni & Urs Schüffelgen & Jerome Sallet & Matthew F. S. Rushworth & Nils Kolling, 2024. "General mechanisms of task engagement in the primate frontal cortex," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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