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Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion

Author

Listed:
  • Hiroyuki Kawai

    (Kyoto University
    Osaka Metropolitan University)

  • Youcef Bouchekioua

    (Hokkaido University)

  • Naoya Nishitani

    (Kyoto University
    Hokkaido University
    Kanazawa University)

  • Kazuhei Niitani

    (Kanazawa University)

  • Shoma Izumi

    (Kanazawa University)

  • Hinako Morishita

    (Kyoto University)

  • Chihiro Andoh

    (Kyoto University)

  • Yuma Nagai

    (Kyoto University)

  • Masashi Koda

    (Kyoto University)

  • Masako Hagiwara

    (Kyoto University)

  • Koji Toda

    (Keio University)

  • Hisashi Shirakawa

    (Kyoto University)

  • Kazuki Nagayasu

    (Kyoto University)

  • Yu Ohmura

    (Hokkaido University)

  • Makoto Kondo

    (Osaka Metropolitan University)

  • Katsuyuki Kaneda

    (Kanazawa University)

  • Mitsuhiro Yoshioka

    (Hokkaido University)

  • Shuji Kaneko

    (Kyoto University)

Abstract

Appropriate processing of reward and aversive information is essential for survival. Although a critical role of serotonergic neurons in the dorsal raphe nucleus (DRN) in reward processing has been shown, the lack of rewarding effects with selective serotonin reuptake inhibitors (SSRIs) implies the presence of a discrete serotonergic system playing an opposite role to the DRN in the processing of reward and aversive stimuli. Here, we demonstrated that serotonergic neurons in the median raphe nucleus (MRN) of mice process reward and aversive information in opposite directions to DRN serotonergic neurons. We further identified MRN serotonergic neurons, including those projecting to the interpeduncular nucleus (5-HTMRN→IPN), as a key mediator of reward and aversive stimuli. Moreover, 5-HT receptors, including 5-HT2A receptors in the interpeduncular nucleus, are involved in the aversive properties of MRN serotonergic neural activity. Our findings revealed an essential function of MRN serotonergic neurons, including 5-HTMRN→IPN, in the processing of reward and aversive stimuli.

Suggested Citation

  • Hiroyuki Kawai & Youcef Bouchekioua & Naoya Nishitani & Kazuhei Niitani & Shoma Izumi & Hinako Morishita & Chihiro Andoh & Yuma Nagai & Masashi Koda & Masako Hagiwara & Koji Toda & Hisashi Shirakawa &, 2022. "Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35346-7
    DOI: 10.1038/s41467-022-35346-7
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    References listed on IDEAS

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