IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-45348-2.html
   My bibliography  Save this article

An intranasal live-attenuated SARS-CoV-2 vaccine limits virus transmission

Author

Listed:
  • Julia M. Adler

    (Freie Universität Berlin)

  • Ricardo Martin Vidal

    (Freie Universität Berlin)

  • Christine Langner

    (Freie Universität Berlin)

  • Daria Vladimirova

    (Freie Universität Berlin)

  • Azza Abdelgawad

    (Freie Universität Berlin)

  • Daniela Kunecova

    (Freie Universität Berlin)

  • Xiaoyuan Lin

    (Freie Universität Berlin
    Chongqing University)

  • Geraldine Nouailles

    (Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Anne Voss

    (Freie Universität Berlin)

  • Sandra Kunder

    (Freie Universität Berlin)

  • Achim D. Gruber

    (Freie Universität Berlin)

  • Haibo Wu

    (Chongqing University)

  • Nikolaus Osterrieder

    (Freie Universität Berlin)

  • Dusan Kunec

    (Freie Universität Berlin)

  • Jakob Trimpert

    (Freie Universität Berlin)

Abstract

The development of effective SARS-CoV-2 vaccines has been essential to control COVID-19, but significant challenges remain. One problem is intramuscular administration, which does not induce robust mucosal immune responses in the upper airways—the primary site of infection and virus shedding. Here we compare the efficacy of a mucosal, replication-competent yet fully attenuated virus vaccine, sCPD9-ΔFCS, and the monovalent mRNA vaccine BNT162b2 in preventing transmission of SARS-CoV-2 variants B.1 and Omicron BA.5 in two scenarios. Firstly, we assessed the protective efficacy of the vaccines by exposing vaccinated male Syrian hamsters to infected counterparts. Secondly, we evaluated transmission of the challenge virus from vaccinated and subsequently challenged male hamsters to naïve contacts. Our findings demonstrate that the live-attenuated vaccine (LAV) sCPD9-ΔFCS significantly outperformed the mRNA vaccine in preventing virus transmission in both scenarios. Our results provide evidence for the advantages of locally administered LAVs over intramuscularly administered mRNA vaccines in preventing infection and reducing virus transmission.

Suggested Citation

  • Julia M. Adler & Ricardo Martin Vidal & Christine Langner & Daria Vladimirova & Azza Abdelgawad & Daniela Kunecova & Xiaoyuan Lin & Geraldine Nouailles & Anne Voss & Sandra Kunder & Achim D. Gruber & , 2024. "An intranasal live-attenuated SARS-CoV-2 vaccine limits virus transmission," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45348-2
    DOI: 10.1038/s41467-024-45348-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-45348-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-45348-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Roman Wölfel & Victor M. Corman & Wolfgang Guggemos & Michael Seilmaier & Sabine Zange & Marcel A. Müller & Daniela Niemeyer & Terry C. Jones & Patrick Vollmar & Camilla Rothe & Michael Hoelscher & To, 2020. "Author Correction: Virological assessment of hospitalized patients with COVID-2019," Nature, Nature, vol. 588(7839), pages 35-35, December.
    2. Ryuta Uraki & Peter J. Halfmann & Shun Iida & Seiya Yamayoshi & Yuri Furusawa & Maki Kiso & Mutsumi Ito & Kiyoko Iwatsuki-Horimoto & Sohtaro Mine & Makoto Kuroda & Tadashi Maemura & Yuko Sakai-Tagawa , 2022. "Characterization of SARS-CoV-2 Omicron BA.4 and BA.5 isolates in rodents," Nature, Nature, vol. 612(7940), pages 540-545, December.
    3. Yunlong Cao & Ayijiang Yisimayi & Fanchong Jian & Weiliang Song & Tianhe Xiao & Lei Wang & Shuo Du & Jing Wang & Qianqian Li & Xiaosu Chen & Yuanling Yu & Peng Wang & Zhiying Zhang & Pulan Liu & Ran A, 2022. "BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection," Nature, Nature, vol. 608(7923), pages 593-602, August.
    4. Kathryn A. Ryan & Kevin R. Bewley & Susan A. Fotheringham & Gillian S. Slack & Phillip Brown & Yper Hall & Nadina I. Wand & Anthony C. Marriott & Breeze E. Cavell & Julia A. Tree & Lauren Allen & Mari, 2021. "Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    5. Khadija Khan & Farina Karim & Yashica Ganga & Mallory Bernstein & Zesuliwe Jule & Kajal Reedoy & Sandile Cele & Gila Lustig & Daniel Amoako & Nicole Wolter & Natasha Samsunder & Aida Sivro & James Emm, 2022. "Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection," Nature Communications, Nature, vol. 13(1), pages 1-7, December.
    6. Roman Wölfel & Victor M. Corman & Wolfgang Guggemos & Michael Seilmaier & Sabine Zange & Marcel A. Müller & Daniela Niemeyer & Terry C. Jones & Patrick Vollmar & Camilla Rothe & Michael Hoelscher & To, 2020. "Virological assessment of hospitalized patients with COVID-2019," Nature, Nature, vol. 581(7809), pages 465-469, May.
    7. Sin Fun Sia & Li-Meng Yan & Alex W. H. Chin & Kevin Fung & Ka-Tim Choy & Alvina Y. L. Wong & Prathanporn Kaewpreedee & Ranawaka A. P. M. Perera & Leo L. M. Poon & John M. Nicholls & Malik Peiris & Hui, 2020. "Pathogenesis and transmission of SARS-CoV-2 in golden hamsters," Nature, Nature, vol. 583(7818), pages 834-838, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Juan Liu & Fengfeng Mao & Jianhe Chen & Shuaiyao Lu & Yonghe Qi & Yinyan Sun & Linqiang Fang & Man Lung Yeung & Chunmei Liu & Guimei Yu & Guangyu Li & Ximing Liu & Yuansheng Yao & Panpan Huang & Dongx, 2023. "An IgM-like inhalable ACE2 fusion protein broadly neutralizes SARS-CoV-2 variants," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Magen E. Francis & Ethan B. Jansen & Anthony Yourkowski & Alaa Selim & Cynthia L. Swan & Brian K. MacPhee & Brittany Thivierge & Rachelle Buchanan & Kerry J. Lavender & Joseph Darbellay & Matthew B. R, 2023. "Previous infection with seasonal coronaviruses does not protect male Syrian hamsters from challenge with SARS-CoV-2," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    3. Anna Maria Cattelan & Lolita Sasset & Federico Zabeo & Anna Ferrari & Lucia Rossi & Maria Mazzitelli & Silvia Cocchio & Vincenzo Baldo, 2022. "Rapid Antigen Test LumiraDx TM vs. Real Time Polymerase Chain Reaction for the Diagnosis of SARS-CoV-2 Infection: A Retrospective Cohort Study," IJERPH, MDPI, vol. 19(7), pages 1-12, March.
    4. Tobias Schlager & Ashley V. Whillans, 2022. "People underestimate the probability of contracting the coronavirus from friends," Palgrave Communications, Palgrave Macmillan, vol. 9(1), pages 1-11, December.
    5. Joseph Pateras & Preetam Ghosh, 2022. "A Computational Framework for Exploring SARS-CoV-2 Pharmacodynamic Dose and Timing Regimes," Mathematics, MDPI, vol. 10(20), pages 1-12, October.
    6. Marta Baselga & Juan J. Alba & Alberto J. Schuhmacher, 2022. "The Control of Metabolic CO 2 in Public Transport as a Strategy to Reduce the Transmission of Respiratory Infectious Diseases," IJERPH, MDPI, vol. 19(11), pages 1-19, May.
    7. Lisa Cariani & Beatrice Silvia Orena & Federico Ambrogi & Simone Gambazza & Anna Maraschini & Antonella Dodaro & Massimo Oggioni & Annarosa Orlandi & Alessia Pirrone & Sara Uceda Renteria & Mara Berna, 2020. "Time Length of Negativization and Cycle Threshold Values in 182 Healthcare Workers with Covid-19 in Milan, Italy: An Observational Cohort Study," IJERPH, MDPI, vol. 17(15), pages 1-10, July.
    8. Dapeng Li & David R. Martinez & Alexandra Schäfer & Haiyan Chen & Maggie Barr & Laura L. Sutherland & Esther Lee & Robert Parks & Dieter Mielke & Whitney Edwards & Amanda Newman & Kevin W. Bock & Mahn, 2022. "Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    9. Felix Dewald & Martin Pirkl & Martha Paluschinski & Joachim Kühn & Carina Elsner & Bianca Schulte & Jacqueline Knüfer & Elvin Ahmadov & Maike Schlotz & Göksu Oral & Michael Bernhard & Mark Michael & M, 2023. "Impaired humoral immunity to BQ.1.1 in convalescent and vaccinated patients," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    10. Susanna Esposito & Federico Marchetti & Marcello Lanari & Fabio Caramelli & Alessandro De Fanti & Gianluca Vergine & Lorenzo Iughetti & Martina Fornaro & Agnese Suppiej & Stefano Zona & Andrea Pession, 2021. "COVID-19 Management in the Pediatric Age: Consensus Document of the COVID-19 Working Group in Paediatrics of the Emilia-Romagna Region (RE-CO-Ped), Italy," IJERPH, MDPI, vol. 18(8), pages 1-29, April.
    11. Ramon Roozendaal & Laura Solforosi & Daniel J. Stieh & Jan Serroyen & Roel Straetemans & Anna Dari & Muriel Boulton & Frank Wegmann & Sietske K. Rosendahl Huber & Joan E. M. van der Lubbe & Jenny Hend, 2021. "SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    12. Shengwei Zhu & Tong Lin & John D. Spengler & Jose Guillermo Cedeño Laurent & Jelena Srebric, 2022. "The Influence of Plastic Barriers on Aerosol Infection Risk during Airport Security Checks," Sustainability, MDPI, vol. 14(18), pages 1-14, September.
    13. Sasha Harris-Lovett & Kara L. Nelson & Paloma Beamer & Heather N. Bischel & Aaron Bivins & Andrea Bruder & Caitlyn Butler & Todd D. Camenisch & Susan K. De Long & Smruthi Karthikeyan & David A. Larsen, 2021. "Wastewater Surveillance for SARS-CoV-2 on College Campuses: Initial Efforts, Lessons Learned, and Research Needs," IJERPH, MDPI, vol. 18(9), pages 1-20, April.
    14. Maria de Lourdes Aguiar-Oliveira & Aline Campos & Aline R. Matos & Caroline Rigotto & Adriana Sotero-Martins & Paulo F. P. Teixeira & Marilda M. Siqueira, 2020. "Wastewater-Based Epidemiology (WBE) and Viral Detection in Polluted Surface Water: A Valuable Tool for COVID-19 Surveillance—A Brief Review," IJERPH, MDPI, vol. 17(24), pages 1-19, December.
    15. Rabih Ghostine & Mohamad Gharamti & Sally Hassrouny & Ibrahim Hoteit, 2021. "Mathematical Modeling of Immune Responses against SARS-CoV-2 Using an Ensemble Kalman Filter," Mathematics, MDPI, vol. 9(19), pages 1-13, September.
    16. Jaclyn A. Kaiser & Christine E. Nelson & Xueqiao Liu & Hong-Su Park & Yumiko Matsuoka & Cindy Luongo & Celia Santos & Laura R. H. Ahlers & Richard Herbert & Ian N. Moore & Temeri Wilder-Kofie & Rashid, 2024. "Mucosal prime-boost immunization with live murine pneumonia virus-vectored SARS-CoV-2 vaccine is protective in macaques," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    17. Chih-Chia Hsieh & Chih-Hao Lin & William Yu Chung Wang & David J. Pauleen & Jengchung Victor Chen, 2020. "The Outcome and Implications of Public Precautionary Measures in Taiwan–Declining Respiratory Disease Cases in the COVID-19 Pandemic," IJERPH, MDPI, vol. 17(13), pages 1-10, July.
    18. Abdin, Adam F. & Fang, Yi-Ping & Caunhye, Aakil & Alem, Douglas & Barros, Anne & Zio, Enrico, 2023. "An optimization model for planning testing and control strategies to limit the spread of a pandemic – The case of COVID-19," European Journal of Operational Research, Elsevier, vol. 304(1), pages 308-324.
    19. Jos Lelieveld & Frank Helleis & Stephan Borrmann & Yafang Cheng & Frank Drewnick & Gerald Haug & Thomas Klimach & Jean Sciare & Hang Su & Ulrich Pöschl, 2020. "Model Calculations of Aerosol Transmission and Infection Risk of COVID-19 in Indoor Environments," IJERPH, MDPI, vol. 17(21), pages 1-18, November.
    20. Ledyz Cuesta-Herrera & Luis Pastenes & Ariel D. Arencibia & Fernando Córdova-Lepe & Cristhian Montoya, 2024. "Dynamics of Activation and Regulation of the Immune Response to Attack by Viral Pathogens Using Mathematical Modeling," Mathematics, MDPI, vol. 12(17), pages 1-15, August.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45348-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.