IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-26117-x.html
   My bibliography  Save this article

SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques

Author

Listed:
  • Ramon Roozendaal

    (Janssen Vaccines & Prevention B.V.)

  • Laura Solforosi

    (Janssen Vaccines & Prevention B.V.)

  • Daniel J. Stieh

    (Janssen Vaccines & Prevention B.V.)

  • Jan Serroyen

    (Janssen Vaccines & Prevention B.V.)

  • Roel Straetemans

    (Janssen R&D)

  • Anna Dari

    (Janssen R&D)

  • Muriel Boulton

    (Janssen R&D)

  • Frank Wegmann

    (Janssen Vaccines & Prevention B.V.)

  • Sietske K. Rosendahl Huber

    (Janssen Vaccines & Prevention B.V.)

  • Joan E. M. van der Lubbe

    (Janssen Vaccines & Prevention B.V.)

  • Jenny Hendriks

    (Janssen Vaccines & Prevention B.V.)

  • Mathieu Le Gars

    (Janssen Vaccines & Prevention B.V.)

  • Liesbeth Dekking

    (Janssen Vaccines & Prevention B.V.)

  • Dominika N. Czapska-Casey

    (Janssen Vaccines & Prevention B.V.)

  • Nuria Guimera

    (Janssen Vaccines & Prevention B.V.)

  • Sarah Janssen

    (Janssen Vaccines & Prevention B.V.)

  • Sarah Tete

    (Janssen Vaccines & Prevention B.V.)

  • Abishek Chandrashekar

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Noe B. Mercado

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Jingyou Yu

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Wouter Koudstaal

    (Lucidity Biomedical Consulting)

  • Juan J. Perez-Ruixo

    (Janssen R&D)

  • Jerry Sadoff

    (Janssen Vaccines & Prevention B.V.)

  • Dan H. Barouch

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
    Ragon Institute of MGH, MIT and Harvard
    Harvard Medical School
    Massachusetts Consortium on Pathogen Readiness)

  • Hanneke Schuitemaker

    (Janssen Vaccines & Prevention B.V.)

  • Roland Zahn

    (Janssen Vaccines & Prevention B.V.)

Abstract

Several COVID-19 vaccines have recently gained authorization for emergency use. Limited knowledge on duration of immunity and efficacy of these vaccines is currently available. Data on other coronaviruses after natural infection suggest that immunity to SARS-CoV-2 might be short-lived, and preliminary evidence indicates waning antibody titers following SARS-CoV-2 infection. In this work, we model the relationship between immunogenicity and protective efficacy of a series of Ad26 vectors encoding stabilized variants of the SARS-CoV-2 Spike protein in rhesus macaques and validate the analyses by challenging macaques 6 months after immunization with the Ad26.COV2.S vaccine candidate that has been selected for clinical development. We show that Ad26.COV2.S confers durable protection against replication of SARS-CoV-2 in the lungs that is predicted by the levels of Spike-binding and neutralizing antibodies, indicating that Ad26.COV2.S could confer durable protection in humans and immunological correlates of protection may enable the prediction of durability of protection.

Suggested Citation

  • Ramon Roozendaal & Laura Solforosi & Daniel J. Stieh & Jan Serroyen & Roel Straetemans & Anna Dari & Muriel Boulton & Frank Wegmann & Sietske K. Rosendahl Huber & Joan E. M. van der Lubbe & Jenny Hend, 2021. "SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26117-x
    DOI: 10.1038/s41467-021-26117-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-26117-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-26117-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Roman Wölfel & Victor M. Corman & Wolfgang Guggemos & Michael Seilmaier & Sabine Zange & Marcel A. Müller & Daniela Niemeyer & Terry C. Jones & Patrick Vollmar & Camilla Rothe & Michael Hoelscher & To, 2020. "Author Correction: Virological assessment of hospitalized patients with COVID-2019," Nature, Nature, vol. 588(7839), pages 35-35, December.
    2. Noe B. Mercado & Roland Zahn & Frank Wegmann & Carolin Loos & Abishek Chandrashekar & Jingyou Yu & Jinyan Liu & Lauren Peter & Katherine McMahan & Lisa H. Tostanoski & Xuan He & David R. Martinez & Lu, 2020. "Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques," Nature, Nature, vol. 586(7830), pages 583-588, October.
    3. Bates, Douglas & Mächler, Martin & Bolker, Ben & Walker, Steve, 2015. "Fitting Linear Mixed-Effects Models Using lme4," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 67(i01).
    4. Zhi-yong Yang & Wing-pui Kong & Yue Huang & Anjeanette Roberts & Brian R. Murphy & Kanta Subbarao & Gary J. Nabel, 2004. "A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice," Nature, Nature, vol. 428(6982), pages 561-564, April.
    5. Christian Gaebler & Zijun Wang & Julio C. C. Lorenzi & Frauke Muecksch & Shlomo Finkin & Minami Tokuyama & Alice Cho & Mila Jankovic & Dennis Schaefer-Babajew & Thiago Y. Oliveira & Melissa Cipolla & , 2021. "Evolution of antibody immunity to SARS-CoV-2," Nature, Nature, vol. 591(7851), pages 639-644, March.
    6. Roman Wölfel & Victor M. Corman & Wolfgang Guggemos & Michael Seilmaier & Sabine Zange & Marcel A. Müller & Daniela Niemeyer & Terry C. Jones & Patrick Vollmar & Camilla Rothe & Michael Hoelscher & To, 2020. "Virological assessment of hospitalized patients with COVID-2019," Nature, Nature, vol. 581(7809), pages 465-469, May.
    7. Katherine McMahan & Jingyou Yu & Noe B. Mercado & Carolin Loos & Lisa H. Tostanoski & Abishek Chandrashekar & Jinyan Liu & Lauren Peter & Caroline Atyeo & Alex Zhu & Esther A. Bondzie & Gabriel Dagott, 2021. "Correlates of protection against SARS-CoV-2 in rhesus macaques," Nature, Nature, vol. 590(7847), pages 630-634, February.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Dapeng Li & David R. Martinez & Alexandra Schäfer & Haiyan Chen & Maggie Barr & Laura L. Sutherland & Esther Lee & Robert Parks & Dieter Mielke & Whitney Edwards & Amanda Newman & Kevin W. Bock & Mahn, 2022. "Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Juan Liu & Fengfeng Mao & Jianhe Chen & Shuaiyao Lu & Yonghe Qi & Yinyan Sun & Linqiang Fang & Man Lung Yeung & Chunmei Liu & Guimei Yu & Guangyu Li & Ximing Liu & Yuansheng Yao & Panpan Huang & Dongx, 2023. "An IgM-like inhalable ACE2 fusion protein broadly neutralizes SARS-CoV-2 variants," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Jaclyn A. Kaiser & Christine E. Nelson & Xueqiao Liu & Hong-Su Park & Yumiko Matsuoka & Cindy Luongo & Celia Santos & Laura R. H. Ahlers & Richard Herbert & Ian N. Moore & Temeri Wilder-Kofie & Rashid, 2024. "Mucosal prime-boost immunization with live murine pneumonia virus-vectored SARS-CoV-2 vaccine is protective in macaques," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Monica Neagu & Carolina Constantin & Mihaela Surcel, 2021. "Testing Antigens, Antibodies, and Immune Cells in COVID-19 as a Public Health Topic—Experience and Outlines," IJERPH, MDPI, vol. 18(24), pages 1-16, December.
    5. Amit A. Upadhyay & Elise G. Viox & Timothy N. Hoang & Arun K. Boddapati & Maria Pino & Michelle Y.-H. Lee & Jacqueline Corry & Zachary Strongin & David A. Cowan & Elizabeth N. Beagle & Tristan R. Hort, 2023. "TREM2+ and interstitial-like macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    6. Shanlin Ke & Scott T. Weiss & Yang-Yu Liu, 2022. "Dissecting the role of the human microbiome in COVID-19 via metagenome-assembled genomes," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    7. Tobias Schlager & Ashley V. Whillans, 2022. "People underestimate the probability of contracting the coronavirus from friends," Palgrave Communications, Palgrave Macmillan, vol. 9(1), pages 1-11, December.
    8. Joseph Pateras & Preetam Ghosh, 2022. "A Computational Framework for Exploring SARS-CoV-2 Pharmacodynamic Dose and Timing Regimes," Mathematics, MDPI, vol. 10(20), pages 1-12, October.
    9. Marta Baselga & Juan J. Alba & Alberto J. Schuhmacher, 2022. "The Control of Metabolic CO 2 in Public Transport as a Strategy to Reduce the Transmission of Respiratory Infectious Diseases," IJERPH, MDPI, vol. 19(11), pages 1-19, May.
    10. Lisa Cariani & Beatrice Silvia Orena & Federico Ambrogi & Simone Gambazza & Anna Maraschini & Antonella Dodaro & Massimo Oggioni & Annarosa Orlandi & Alessia Pirrone & Sara Uceda Renteria & Mara Berna, 2020. "Time Length of Negativization and Cycle Threshold Values in 182 Healthcare Workers with Covid-19 in Milan, Italy: An Observational Cohort Study," IJERPH, MDPI, vol. 17(15), pages 1-10, July.
    11. Lorenz Schubert & Robert Strassl & Heinz Burgmann & Gabriella Dvorak & Matthias Karer & Michael Kundi & Manuel Kussmann & Heimo Lagler & Felix Lötsch & Christopher Milacek & Markus Obermueller & Zoe O, 2021. "A Longitudinal Seroprevalence Study Evaluating Infection Control and Prevention Strategies at a Large Tertiary Care Center with Low COVID-19 Incidence," IJERPH, MDPI, vol. 18(8), pages 1-10, April.
    12. Susanna Esposito & Federico Marchetti & Marcello Lanari & Fabio Caramelli & Alessandro De Fanti & Gianluca Vergine & Lorenzo Iughetti & Martina Fornaro & Agnese Suppiej & Stefano Zona & Andrea Pession, 2021. "COVID-19 Management in the Pediatric Age: Consensus Document of the COVID-19 Working Group in Paediatrics of the Emilia-Romagna Region (RE-CO-Ped), Italy," IJERPH, MDPI, vol. 18(8), pages 1-29, April.
    13. Shengwei Zhu & Tong Lin & John D. Spengler & Jose Guillermo Cedeño Laurent & Jelena Srebric, 2022. "The Influence of Plastic Barriers on Aerosol Infection Risk during Airport Security Checks," Sustainability, MDPI, vol. 14(18), pages 1-14, September.
    14. Sasha Harris-Lovett & Kara L. Nelson & Paloma Beamer & Heather N. Bischel & Aaron Bivins & Andrea Bruder & Caitlyn Butler & Todd D. Camenisch & Susan K. De Long & Smruthi Karthikeyan & David A. Larsen, 2021. "Wastewater Surveillance for SARS-CoV-2 on College Campuses: Initial Efforts, Lessons Learned, and Research Needs," IJERPH, MDPI, vol. 18(9), pages 1-20, April.
    15. Maria de Lourdes Aguiar-Oliveira & Aline Campos & Aline R. Matos & Caroline Rigotto & Adriana Sotero-Martins & Paulo F. P. Teixeira & Marilda M. Siqueira, 2020. "Wastewater-Based Epidemiology (WBE) and Viral Detection in Polluted Surface Water: A Valuable Tool for COVID-19 Surveillance—A Brief Review," IJERPH, MDPI, vol. 17(24), pages 1-19, December.
    16. Kumawat, Nitesh & Rashid, Mubasher & Srivastava, Akriti & Tripathi, Jai Prakash, 2023. "Hysteresis and Hopf bifurcation: Deciphering the dynamics of an in-host model of SARS-CoV-2 with logistic target cell growth and sigmoidal immune response," Chaos, Solitons & Fractals, Elsevier, vol. 176(C).
    17. Nagel, Kai & Rakow, Christian & Müller, Sebastian A., 2021. "Realistic agent-based simulation of infection dynamics and percolation," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 584(C).
    18. Rabih Ghostine & Mohamad Gharamti & Sally Hassrouny & Ibrahim Hoteit, 2021. "Mathematical Modeling of Immune Responses against SARS-CoV-2 Using an Ensemble Kalman Filter," Mathematics, MDPI, vol. 9(19), pages 1-13, September.
    19. Patrick T. Acer & Lauren M. Kelly & Andrew A. Lover & Caitlyn S. Butler, 2022. "Quantifying the Relationship between SARS-CoV-2 Wastewater Concentrations and Building-Level COVID-19 Prevalence at an Isolation Residence: A Passive Sampling Approach," IJERPH, MDPI, vol. 19(18), pages 1-15, September.
    20. Afnan Al Agha & Safiya Alshehaiween & Ahmed Elaiw & Matuka Alshaikh, 2021. "A Global Analysis of Delayed SARS-CoV-2/Cancer Model with Immune Response," Mathematics, MDPI, vol. 9(11), pages 1-27, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26117-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.