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Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection

Author

Listed:
  • Khadija Khan

    (Africa Health Research Institute
    University of KwaZulu-Natal)

  • Farina Karim

    (Africa Health Research Institute
    University of KwaZulu-Natal)

  • Yashica Ganga

    (Africa Health Research Institute)

  • Mallory Bernstein

    (Africa Health Research Institute)

  • Zesuliwe Jule

    (Africa Health Research Institute)

  • Kajal Reedoy

    (Africa Health Research Institute)

  • Sandile Cele

    (Africa Health Research Institute
    University of KwaZulu-Natal)

  • Gila Lustig

    (Centre for the AIDS Programme of Research in South Africa)

  • Daniel Amoako

    (National Institute for Communicable Diseases of the National Health Laboratory Service
    University of KwaZulu-Natal)

  • Nicole Wolter

    (National Institute for Communicable Diseases of the National Health Laboratory Service
    University of the Witwatersrand)

  • Natasha Samsunder

    (Centre for the AIDS Programme of Research in South Africa)

  • Aida Sivro

    (Centre for the AIDS Programme of Research in South Africa
    University of KwaZulu-Natal)

  • James Emmanuel San

    (KwaZulu-Natal Research Innovation and Sequencing Platform)

  • Jennifer Giandhari

    (KwaZulu-Natal Research Innovation and Sequencing Platform)

  • Houriiyah Tegally

    (KwaZulu-Natal Research Innovation and Sequencing Platform
    Stellenbosch University)

  • Sureshnee Pillay

    (KwaZulu-Natal Research Innovation and Sequencing Platform)

  • Yeshnee Naidoo

    (KwaZulu-Natal Research Innovation and Sequencing Platform)

  • Matilda Mazibuko

    (Africa Health Research Institute)

  • Yoliswa Miya

    (Africa Health Research Institute)

  • Nokuthula Ngcobo

    (Africa Health Research Institute)

  • Nithendra Manickchund

    (University of KwaZulu-Natal)

  • Nombulelo Magula

    (University of Kwa-Zulu Natal)

  • Quarraisha Abdool Karim

    (Centre for the AIDS Programme of Research in South Africa
    Columbia University)

  • Anne Gottberg

    (National Institute for Communicable Diseases of the National Health Laboratory Service
    University of the Witwatersrand)

  • Salim S. Abdool Karim

    (Centre for the AIDS Programme of Research in South Africa
    Columbia University)

  • Willem Hanekom

    (Africa Health Research Institute
    University College London)

  • Bernadett I. Gosnell

    (University of KwaZulu-Natal)

  • Richard J. Lessells

    (KwaZulu-Natal Research Innovation and Sequencing Platform)

  • Tulio Oliveira

    (KwaZulu-Natal Research Innovation and Sequencing Platform
    Stellenbosch University
    University of Washington)

  • Mahomed-Yunus S. Moosa

    (University of KwaZulu-Natal)

  • Alex Sigal

    (Africa Health Research Institute
    University of KwaZulu-Natal
    Centre for the AIDS Programme of Research in South Africa
    Max Planck Institute for Infection Biology)

Abstract

SARS-CoV-2 Omicron (B.1.1.529) BA.4 and BA.5 sub-lineages, first detected in South Africa, have changes relative to Omicron BA.1 including substitutions in the spike receptor binding domain. Here we isolated live BA.4 and BA.5 viruses and measured BA.4/BA.5 neutralization elicited by BA.1 infection either in the absence or presence of previous vaccination as well as from vaccination without BA.1 infection. In BA.1-infected unvaccinated individuals, neutralization relative to BA.1 declines 7.6-fold for BA.4 and 7.5-fold for BA.5. In vaccinated individuals with subsequent BA.1 infection, neutralization relative to BA.1 decreases 3.2-fold for BA.4 and 2.6-fold for BA.5. The fold-drop versus ancestral virus neutralization in this group is 4.0-fold for BA.1, 12.9-fold for BA.4, and 10.3-fold for BA.5. In contrast, BA.4/BA.5 escape is similar to BA.1 in the absence of BA.1 elicited immunity: fold-drop relative to ancestral virus neutralization is 19.8-fold for BA.1, 19.6-fold for BA.4, and 20.9-fold for BA.5. These results show considerable escape of BA.4/BA.5 from BA.1 elicited immunity which is moderated with vaccination and may indicate that BA.4/BA.5 may have the strongest selective advantage in evading neutralization relative to BA.1 in unvaccinated, BA.1 infected individuals.

Suggested Citation

  • Khadija Khan & Farina Karim & Yashica Ganga & Mallory Bernstein & Zesuliwe Jule & Kajal Reedoy & Sandile Cele & Gila Lustig & Daniel Amoako & Nicole Wolter & Natasha Samsunder & Aida Sivro & James Emm, 2022. "Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection," Nature Communications, Nature, vol. 13(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32396-9
    DOI: 10.1038/s41467-022-32396-9
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    1. Yunlong Cao & Jing Wang & Fanchong Jian & Tianhe Xiao & Weiliang Song & Ayijiang Yisimayi & Weijin Huang & Qianqian Li & Peng Wang & Ran An & Jing Wang & Yao Wang & Xiao Niu & Sijie Yang & Hui Liang &, 2022. "Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies," Nature, Nature, vol. 602(7898), pages 657-663, February.
    2. Allison J. Greaney & Tyler N. Starr & Christopher O. Barnes & Yiska Weisblum & Fabian Schmidt & Marina Caskey & Christian Gaebler & Alice Cho & Marianna Agudelo & Shlomo Finkin & Zijun Wang & Daniel P, 2021. "Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    3. Lihong Liu & Sho Iketani & Yicheng Guo & Jasper F.-W. Chan & Maple Wang & Liyuan Liu & Yang Luo & Hin Chu & Yiming Huang & Manoj S. Nair & Jian Yu & Kenn K.-H. Chik & Terrence T.-T. Yuen & Chaemin Yoo, 2022. "Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2," Nature, Nature, vol. 602(7898), pages 676-681, February.
    4. Christopher O. Barnes & Claudia A. Jette & Morgan E. Abernathy & Kim-Marie A. Dam & Shannon R. Esswein & Harry B. Gristick & Andrey G. Malyutin & Naima G. Sharaf & Kathryn E. Huey-Tubman & Yu E. Lee &, 2020. "SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies," Nature, Nature, vol. 588(7839), pages 682-687, December.
    5. Delphine Planas & Nell Saunders & Piet Maes & Florence Guivel-Benhassine & Cyril Planchais & Julian Buchrieser & William-Henry Bolland & Françoise Porrot & Isabelle Staropoli & Frederic Lemoine & Hélè, 2022. "Considerable escape of SARS-CoV-2 Omicron to antibody neutralization," Nature, Nature, vol. 602(7898), pages 671-675, February.
    6. Khadija Khan & Farina Karim & Sandile Cele & Kajal Reedoy & James Emmanuel San & Gila Lustig & Houriiyah Tegally & Yuval Rosenberg & Mallory Bernstein & Zesuliwe Jule & Yashica Ganga & Nokuthula Ngcob, 2022. "Omicron infection enhances Delta antibody immunity in vaccinated persons," Nature, Nature, vol. 607(7918), pages 356-359, July.
    7. Sandile Cele & Inbal Gazy & Laurelle Jackson & Shi-Hsia Hwa & Houriiyah Tegally & Gila Lustig & Jennifer Giandhari & Sureshnee Pillay & Eduan Wilkinson & Yeshnee Naidoo & Farina Karim & Yashica Ganga , 2021. "Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma," Nature, Nature, vol. 593(7857), pages 142-146, May.
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    2. Zeng, Lang & Chen, Yushu & Liu, Yiwen & Tang, Ming & Liu, Ying & Jin, Zhen & Do, Younghae & Pelinovsky, E. & Kirillin, M. & Macau, E., 2024. "The impact of social interventions on COVID-19 spreading based on multilayer commuter networks," Chaos, Solitons & Fractals, Elsevier, vol. 185(C).
    3. Yu Guo & Guangshun Zhang & Qi Yang & Xiaowei Xie & Yang Lu & Xuelian Cheng & Hui Wang & Jingxi Liang & Jielin Tang & Yuxin Gao & Hang Shang & Jun Dai & Yongxia Shi & Jiaxi Zhou & Jun Zhou & Hangtian G, 2023. "Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
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    5. Magen E. Francis & Ethan B. Jansen & Anthony Yourkowski & Alaa Selim & Cynthia L. Swan & Brian K. MacPhee & Brittany Thivierge & Rachelle Buchanan & Kerry J. Lavender & Joseph Darbellay & Matthew B. R, 2023. "Previous infection with seasonal coronaviruses does not protect male Syrian hamsters from challenge with SARS-CoV-2," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
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    8. Annika Rössler & Antonia Netzl & Ludwig Knabl & David Bante & Samuel H. Wilks & Wegene Borena & Dorothee Laer & Derek J. Smith & Janine Kimpel, 2023. "Characterizing SARS-CoV-2 neutralization profiles after bivalent boosting using antigenic cartography," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
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